Topbp1

BRCT Domaincontaining Protein TopBP1 Functions in DNA Replication and

Model for TopBP1 localization and function at mitosis top Overview

TopBP1 assembles nuclear condensates to switch on ATR signaling

DNA damage response protein TOPBP1 regulates X chromosome silencing in

CIP2A Interacts with TopBP1 and Drives BasalLike Breast Cancer

TopBP1 Controls BLM Protein Level to Maintain Genome Stability PMC

Molecular Basis of BACH1FANCJ Recognition by TopBP1 in DNA Replication

TopBP1 assembles nuclear condensates to switch on ATR signaling

BRCT Domaincontaining Protein TopBP1 Functions in DNA Replication and

A smallmolecule inhibitor of TopBP1 exerts antiMYC activity and

BRCT Domaincontaining Protein TopBP1 Functions in DNA Replication and

TopBP1 assembles nuclear condensates to switch on ATR signaling

TopBP1 is recruited to RPAssDNA in a manner dependent on ATRIP A

TOPBP1 accumulation at sites of mitotic DSBs is dependent on CIP2A and

Characterization of TOPBP1Treacle interaction A Scheme of TOPBP1

TopBP1 colocalizes with DNA synthesis in mitosis A Schematic

Mitotic TopBP1 foci can transition into 53BP1 NBs in G1 A

TopBP1 is a key component of correct HPV E1E2 mediated DNA

TopBP1 Interacts with PHF8 through residue R1314 of TopBP1 A

Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA

Targeting TopBP1 at a convergent point of multiple oncogenic pathways

TopBP1 interacts with MDC1 A Endogenous interaction between TopBP1

Immunohistochemical analysis of TopBP1 protein expression a

DNA damage response protein TOPBP1 regulates X chromosome silencing in

TopBP1 colocalizes with DNA synthesis in mitosis A Schematic

TOPBP1 Gene GeneCards TOPB1 Protein TOPB1 Antibody

An integrated model for the function of TopBP1 in the normal cell cycle

TOPBP1 is a novel TOP2Ainteracting protein that localizes to UFBs

Targeting TopBP1 at a convergent point of multiple oncogenic pathways

TopBP1 accumulation at stalled replication forks requires TopBP1 BRCT5

PDF TopBP1 in DNA Damage Response

TOPBP1 Gene GeneCards TOPB1 Protein TOPB1 Antibody

Dependence of DNAbinding activity of TopBP1 for ATR activation A

TopBP1 colocalizes with DNA synthesis in mitosis A Schematic

The relationship between TopBP1 mRNA and protein expression and the

TopBP1 utilises a bipartite GINS binding mode to support genome

TopBP1 colocalizes with DNA synthesis in mitosis A Schematic

TopBP1 assembles nuclear condensates to switch on ATR signaling

Targeting TopBP1 at a convergent point of multiple oncogenic pathways

TOPBP1 Can Bridge MDC1Bound DSBs Acquired during Mitosis A Examples

TOPBP1 interacts with PLK1 Immunoblots of control antiPLK1 A or

TopBP1 assembles nuclear condensates to switch on ATR signaling

TopBP1 and prerRNA form liquidliquid phase separation in vitro A

TOPBP1 and Treacle prevent replication stressinduced silencing of

An integrated model for the function of TopBP1 in the normal cell cycle

TOPBP1 Wikipedia

TOPBP1 and Treacle facilitate recruitment of replication stress

TopBP1 fragments used in this study and their DNA binding properties

TopBP1 utilises a bipartite GINS binding mode to support genome

CIP2A and TOPBP1 localize to underreplicated DNA in mitotic cells a

TOPBP1 takes RADical command in recombinational DNA repair PMC

TOPBP1 Wikipedia

BRCT Domaincontaining Protein TopBP1 Functions in DNA Replication and

TOPBP1 and Treacle maintain genome stability during nucleolar

TopBP1 utilises a bipartite GINS binding mode to support genome

Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA

The relationship between TopBP1 mRNA and protein expression and the

A TopBP1 depletion has the same effects when using a different

TopBP1 assembles nuclear condensates to switch on ATR signaling

BRCT Domaincontaining Protein TopBP1 Functions in DNA Replication and

TopBP1 assembles nuclear condensates to switch on ATR signaling

TOPBP1 regulates HR A Immunofluorescence of U2OS cells treated with

Proteomic analysis of TOPBP1 interactions modulated by replication

TopBP1 coordinates DNA repair synthesis in mitosis via recruitment of

TOPBP1 is dispensable for DNA end resection and RPA32 loading A

Multiple pathways for TOPBP1 recruitment and ATR activation by DSBs in

TopBP1 overexpression leads to increased acinar size in MCF10A 3D

TopBP1 utilises a bipartite GINS binding mode to support genome

BRCT Domaincontaining Protein TopBP1 Functions in DNA Replication and

TopBP1 is a key component of correct HPV E1E2 mediated DNA

Targeting TopBP1 at a convergent point of multiple oncogenic pathways

TopBP1 utilises a bipartite GINS binding mode to support genome

TopBP1 Controls BLM Protein Level to Maintain Genome Stability

Two conserved sequence segments in TOPBP1 mediate its interaction with

PDF Function of TopBP1 in Genome Stability

TopBP1 colocalizes with DNA synthesis in mitosis A Schematic

TopBP1 is necessary for ATR activation and increased expression of DNA

Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA

TopBP1 overexpression disrupts cell polarity Representative images of

TOPBP1 Wikipedia

TOPBP1 Gene GeneCards TOPB1 Protein TOPB1 Antibody

Expression of TopBP1 mRNA measured by realtime PCR a in normal breast

TopBP1 focus formation depends on H2AXMDC1 but not on RNF8 after

A TopBP1 depletion has the same effects when using a different

TopBP1IN1 TopBP1 Inhibitor MedChemExpress

TOPBP1 Gene GeneCards TOPB1 Protein TOPB1 Antibody

TopBP1 foci accumulate upon NEBD and gradually disappear during

Expression of TopBP1 in hereditary breast cancer PMC

TopBP1 coordinates DNA repair synthesis in mitosis via recruitment of

TOPBP1 Gene GeneCards TOPB1 Protein TOPB1 Antibody

BRCT Domaincontaining Protein TopBP1 Functions in DNA Replication and

TopBP1 Activates the ATRATRIP Complex Cell

TopBP1 OE induces migration and invasion in MCF10A 3D dissociated cells

TopBP1 OE induces DNA damage and DDR activation A and D mCherry MCF10A

TopBP1 depletion modifies E2 subcellular localization A One

TopBP1 overexpression disrupts cell polarity Representative images of

TopBP1 nuclear foci formation induced by replication stress is

DNA damage response protein TOPBP1 regulates X chromosome silencing in

TopBP1 coordinates DNA repair synthesis in mitosis via recruitment of

TopBP1 controls BLM protein level to maintain genome stability

Depletion of TopBP1 in mitosis induces 53BP1 NBs in the next G1 A

HPV11 E2 protein levels are regulated by TopBP1 in NTert1 cells in a

DNA damage response protein TOPBP1 regulates X chromosome silencing in

DNA binding and ATR stimulatory activities of TopBP1 are independent of

A Divergent Role of the SIRT1TopBP1 Axis in Regulating Metabolic

Characterization of the TOPBP1Treacle interaction a Schematic showing

Structure of the Nterminus of TopBP1 A Schematic re Openi

Model for Dpb11TopBP1 function at anaphase bridges During metaphase

af Localisation of topoisomerase II binding protein 1 TopBP1 by

The TopBP1MDC1 interaction is required for replication checkpoint

Functional domains and binding partners of TOPBP1 Please see text for

The Role of DNA Topoisomerase Binding Protein 1 TopBP1 in Genome

TopBP1mediated DNA processing during mitosis Abstract Europe PMC

The Role of DNA Topoisomerase Binding Protein 1 TopBP1 in Genome

BRIT1 is a TopBP1associated protein A U2OS cells were transfected

Topoisomerase IIbinding protein 1 promotes the progression of prostate

Structural Insight into BLM Recognition by TopBP1 Structure

Characterization of the TOPBP1Treacle interaction a Schematic showing

TopBP1 E2 Protein Chart

TopBP1 Mitosis DNA Synthesis

MRN Complex

TopBP1 Immunofluorescence

RPA Phosphorylation

Yeast Dpb11 TopBP1 Structure

TopBP1 Amino Acids Domian

BLM Helicase

53BP1 Foci

TopBP1 Phosphorylation Replisome

ATR Pathway

Eukaryotic DNA Replication

E2F1 Apoptosis

TopBP1 Cdk Phosphorylation Replisome

MDC1

BRCA1 Protein Domains

Fubp2

TopBP1 Mitosis DNA Synthesis Midas

BRCA1 Complex

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