Topbp1 Function

Model for TopBP1 localization and function at mitosis top Overview

TopBP1 and Claspin function synergistically to stimulate ATR

An integrated model for the function of TopBP1 in the normal cell cycle

TopBP1 and Claspin function synergistically to stimulate ATR

PDF Function of TopBP1 in Genome Stability

An Essential Function for the ATRActivationDomain AAD of TopBP1 in

PDF Function of TopBP1 in Genome Stability

BRCT Domaincontaining Protein TopBP1 Functions in DNA Replication and

Model for Dpb11TopBP1 function at anaphase bridges During metaphase

BRCT Domaincontaining Protein TopBP1 Functions in DNA Replication and

A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment

BRCT Domaincontaining Protein TopBP1 Functions in DNA Replication and

Schematic view of functional domains of TopBP1 protein BRCT domains 08

A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment

TopBP1 Interacts with PHF8 through residue R1314 of TopBP1 A

TopBP1 Controls BLM Protein Level to Maintain Genome Stability PMC

DNA damage response protein TOPBP1 regulates X chromosome silencing in

E2 TopBP1 retains transcription function A E2 WT and E2 TopBP1 were

BRCT Domaincontaining Protein TopBP1 Functions in DNA Replication and

TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint PMC

Models for ATR activation A ATR is primarily activated by TOPBP1 in

Cell CycleDependent Switch of TopBP1 Functions by Cdk2 and Akt PMC

TOPBP1 accumulation at sites of mitotic DSBs is dependent on CIP2A and

Cell CycleDependent Switch of TopBP1 Functions by Cdk2 and Akt PMC

BRCT Domaincontaining Protein TopBP1 Functions in DNA Replication and

Cell CycleDependent Switch of TopBP1 Functions by Cdk2 and Akt PMC

TOPBP1 regulates RAD51 phosphorylation and chromatin loading and

Molecular Basis of BACH1FANCJ Recognition by TopBP1 in DNA Replication

TopBP1 Regulates Human Papillomavirus Type 16 E2 Interaction with

TopBP1 interacts with MDC1 A Endogenous interaction between TopBP1

BRCT Domaincontaining Protein TopBP1 Functions in DNA Replication and

TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint PMC

Identification of TopBP1 as a cAblinteracting Protein and a Repressor

Interaction with TopBP1 Is Required for Human Papillomavirus 16 E2

PHF8 interacts with TopBP1 A A List of TopBP1 BRCT78associated

Spatial organization and functions of Chk1 activation by TopBP1

TopBP1 is recruited to RPAssDNA in a manner dependent on ATRIP A

Cell CycleDependent Switch of TopBP1 Functions by Cdk2 and Akt PMC

Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA

TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint PMC

The relationship between TopBP1 mRNA and protein expression and the

BACH1FANCJ Acts with TopBP1 and Participates Early in DNA Replication

Cell CycleDependent Switch of TopBP1 Functions by Cdk2 and Akt PMC

RbE2F pathway specifically regulates the MCM10 and TopBP1 promoter

Relative promoter activities of TOPBP1 transgenic constructs stably

Immunohistochemical analysis of TopBP1 protein expression a

A smallmolecule inhibitor of TopBP1 exerts antiMYC activity and

TOPBP1 Wikipedia

The Cterminal region of TopBP1 binds to branchedDNA structures A

Proteomic analysis of TOPBP1 interactions modulated by replication

The relationship between TopBP1 mRNA and protein expression and the

TopBP1 binds several distinct structures in anaphasetelophase A

The relationship between TopBP1 mRNA and protein expression and the

Interaction with TopBP1 Is Required for Human Papillomavirus 16 E2

TopBP1 is a key component of correct HPV E1E2 mediated DNA

TopBP1 assembles nuclear condensates to switch on ATR signaling

The ATRActivation Domain of TopBP1 Is Required for the Suppression of

Figures and data in SMARCAD1 and TOPBP1 contribute to heterochromatin

TOPBP1 Gene GeneCards TOPB1 Protein TOPB1 Antibody

Phosphopeptidebinding sites in TopBP1 Nterminus A Comparison of

Spatial organization and functions of Chk1 activation by TopBP1

Polθ is phosphorylated by PLK1 and binds to TOPBP1 in mitosis a ...

Pol is phosphorylated by PLK1 and binds to TOPBP1 in mitosis a

Targeting TopBP1 at a convergent point of multiple oncogenic pathways

Characterization of TOPBP1Treacle interaction A Scheme of TOPBP1

TopBP1 fragments used in this study and their DNA binding properties

SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the

DNA damage response protein TOPBP1 regulates X chromosome silencing in

SPBP and TopBP1 interact in vitro via the ePHD and BRCT6 domains A

The ATRActivation Domain of TopBP1 Is Required for the Suppression of

TopBP1 chromatin association is required for pol-α hyperloading and ...

TopBP1 chromatin association is required for pol hyperloading and

Spatial organization and functions of Chk1 activation by TopBP1

TOPBP1 takes RADical command in recombinational DNA repair PMC

Analysis of the requirement of TopBP1 for WRN relocalization and

Schematic representation depicting the role of TopBP1 tumorigenesis

Figure 4 from TopBP1 Deficiency Causes an Early Embryonic Lethality and

Mitotic TopBP1 foci can transition into 53BP1 NBs in G1 A

TOPBP1 is a novel TOP2Ainteracting protein that localizes to UFBs

Spatial organization and functions of Chk1 activation by TopBP1

PDF TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint

TOPBP1 and Treacle prevent replication stressinduced silencing of

TopBP1 colocalizes with SLX4 in mitosis A Representative images of

Identification of critical residues of E2 required for efficient TopBP1

TopBP1 assembles nuclear condensates to switch on ATR signaling

TOPBP1 Gene GeneCards TOPB1 Protein TOPB1 Antibody

Pol is phosphorylated by PLK1 and binds to TOPBP1 in mitosis a

Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA

TOPBP1 is required for phosphorylation of RAD51 at Ser14 A

E 2 modulates TopBP1 protein association with ATR a siRNA knockdown

TopBP1 foci accumulate upon NEBD and gradually disappear during

Depletion of TopBP1 in mitosis induces 53BP1 NBs in the next G1 A

TopBP1 assembles nuclear condensates to switch on ATR signaling

Relative promoter activities of TOPBP1 transgenic constructs stably

TopBP1 focus formation depends on H2AXMDC1 but not on RNF8 after

Characterization of the TOPBP1Treacle interaction a Schematic showing

a–f Localisation of topoisomerase IIβ binding protein 1 (TopBP1) by ...

af Localisation of topoisomerase II binding protein 1 TopBP1 by

Overexpression of TopBP1 a canonical ATRChk1 activator paradoxically

A Divergent Role of the SIRT1TopBP1 Axis in Regulating Metabolic

Relationship between nascent DNA synthesis, Pol-α hyperloading, and ...

Relationship between nascent DNA synthesis Pol hyperloading and

PDF Emerging roles of the CIP2ATopBP1 complex in genome integrity

Singlemolecule imaging reveals the mechanism of bidirectional

PrerRNA Facilitates TopBP1Mediated DNA DoubleStrand Break Response

A Divergent Role of the SIRT1TopBP1 Axis in Regulating Metabolic

PDF PrerRNA Facilitates TopBP1Mediated DNA DoubleStrand Break Response

Full article TopBP1mediated DNA processing during mitosis

Structure of the Nterminus of TopBP1 A Schematic re Openi

TOPBP1dependent phosphorylation GO analysis A Functional GO network

Dpb11 the budding yeast homolog of TopBP1 functions with the

Replication stress stimulates TOPBP1Treacle interaction A Intact

Dpb11 the budding yeast homolog of TopBP1 functions with the

PDF Direct interaction with the BRD4 carboxylterminal motif CTM

PDF Structurefunction analysis of TOPBP1s role in ATR signaling

TopBP1 E2 Protein Chart

TopBP1 Mitosis DNA Synthesis

MRN Complex

TopBP1 Immunofluorescence

RPA Phosphorylation

Yeast Dpb11 TopBP1 Structure

TopBP1 Amino Acids Domian

BLM Helicase

53BP1 Foci

TopBP1 Phosphorylation Replisome

ATR Pathway

Eukaryotic DNA Replication

E2F1 Apoptosis

TopBP1 Cdk Phosphorylation Replisome

MDC1

BRCA1 Protein Domains

Fubp2

TopBP1 Mitosis DNA Synthesis Midas

BRCA1 Complex

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