Top1cc Cpt

HD patientderived fibroblasts show increased TOP1cc levels after CPT

F10 and CPTs both form Top1cc but have different outcomes in response

A model of the molecular mechanism triggered by Top1ccs induced by CPT

Proposed interaction mode of CPT or CFS with Top1 during DNA

F10 and CPTs both form Top1cc but have different outcomes in response

Top 1 inhibition Top1cc and PARP1 induction and Download

Cellular exposure to CPT results in the formation of reversible

ATM modulates Top1 turnover after CPT treatment a Top1 levels were

Top1 inhibition by CPT induces topological mtDNA damage in healthy CD4

Analysis of TOP1 inhibition by CPT and Genz in vitro a The detection of

CPT treatment induces differential TOP1 downregulation in primary and

Analysis of TOP1 inhibition by CPT and Genz in vitro a The detection of

Schematic representation of the proposed effects of CPT and NSC

CPT treatment reduces the halflife of TOP1 dependent on a functional

Scheme of RRM2 induction after CPT treatment Briefly DNA damage

Top 1 inhibition Top1cc and PARP1 induction and Download

HMGB2 stabilizes TOP1cc a b IMR90 cells with or without HMGB2

Top1 inhibition by CPT induces cell dysfunctions in healthy CD4 T cells

CPT treatment reduces the halflife of TOP1 dependent on a functional

CPT sensitivity of human Top1B enzymes relaxing positively supercoiled

WRN is a key regulator of TOP1cc removal and NF‐κB activation. (a–c ...

WRN is a key regulator of TOP1cc removal and NFB activation ac

CPT treatment reduces the halflife of TOP1 dependent on a functional

ATM is essential for DNA damage signaling after CPT treatment a

The TIP pathway for TOP1cc is independent of active DNA replication

Addition of CPT or loss of TOP1α releases DNA methylation. (A ...

Addition of CPT or loss of TOP1 releases DNA methylation A

CPT activation of antisense transcription requires Top1 and is

STUbL mutant tdp1 D cells are synergistically sensitive to CPT and have

CPT treatment causes a reduction in the TOP1 steady state level that is

Top1 inhibition by CPT or cellular oxidative stress induces

Top1 inhibition by CPT induces topological mtDNA damage in healthy CD4

CPT treatment reduces the halflife of TOP1 dependent on a functional

Stabilization of Top1cc at the eRFB1 A Contribution of Download

Role of SALL1 in Top1cc Resolution A Immunofluorescence showing

Scheme of RRM2 induction after CPT treatment Briefly DNA damage

Proteasomedependent processing of TOP1cc leads to excess DSB formation

The p97 ATPase promotes TOP1cc repair a RADAR assay to assess TOP1cc

Nonenzymatic role of WRN in TOP1cc removal a Schematic

Function of Top1cc at the rRFB and link with previously reported DSBs

Proposed mechanism of replicationmediated DSB induction by CPT A

Crossing the border Replication fork adducts move to lysosomes for

TOP1DNA trapping by exatecan and combination therapy with ATR

Strategies Targeting DNA Topoisomerase I in Cancer Chemotherapy

Proposed mechanisms for enhanced g H2AX formation by replication DSBs

TEX264 drives selective autophagy of DNA lesions to promote DNA repair

TyrosylDNA Phosphodiesterase 1 and Topoisomerase I Activities as

Sprtn H MEFs exhibit increased sensitivity to camptothecin and Sprtn

TEX264 drives selective autophagy of DNA lesions to promote DNA repair

Schematic representation of our findings regarding the Top1 dynamics in

Schematic representation of the CPTbinding site in Top1 A and B

NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1

Scheme of yeast screening assay for human TOP1 inhibitors that act as

CPTinduced formation of ubiquitin TOP1 conjugates in tumor cells I

CPTinduced formation of TOP1 cleavable complexes and SUMO1TOP1

Schematic representation of the top1 mutations in the CPTresistant

CPTinduced Top1ccs promote Pol II escape from the HIF1 promoter

RND1 transcripts are closely associated with the presence of TOP1cc a

Mutations in topoisomerase I as a selfresistance mechanism coevolved

Relative in vitro inhibition of Top1 by CPT hCPT and derivatives

Neutral Porphyrin Derivative Exerts Anticancer Activity by Targeting

Molecularmechanisms underlying antitumor effects of CPT Download

Experimental protocol and global impact of Top1 poisoning A

Cellular processing determinants for the activation of damage signals

Frontiers Mitochondrial topoisomerase 1 inhibition induces

Dynamic Effects of Topoisomerase I Inhibition on RLoops and Short

Inhibition of Topoisomerase DNA I TOP1 DNA Damage Repair and

Camptothecin Its Derivatives for Cancer Therapy Biopharma PEG

Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage

Topoisomerase IIβ Deficiency Enhances Camptothecin-induced Apoptosis ...

Topoisomerase II Deficiency Enhances Camptothecininduced Apoptosis

TEX264 drives selective autophagy of DNA lesions to promote DNA repair

PolyADPribose polymers regulate DNA topoisomerase I Top1 nuclear

PARP inhibitor ABT888 promotes CPTinduced prolong Top1 trapping

PDF Targeting DNA repair pathways mechanisms and potential

RNA interacts with topoisomerase I to adjust DNA topology Molecular Cell

CPTinduced Top1ccs promote Pol II escape from the HIF1 promoter

Cellular processing determinants for the activation of damage signals

Epigenetic control of topoisomerase 1 activity presents a cancer

Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage

TEX264 drives selective autophagy of DNA lesions to promote DNA repair

Cellular processing determinants for the activation of damage signals

Patulin and Xestoquinol are inhibitors of DNA topoisomerase 1 PNAS

CPT-induced Top1ccs promote Pol II escape from the HIF-1α promoter ...

CPTinduced Top1ccs promote Pol II escape from the HIF1 promoter

Levels of specific nascent RNAs are increased by CPTinduced Top1ccs

Selective enhancement of CPTinduced trapping of Top1 by N 2 ethyldG

Distinct actions of topoisomerase poisons and inhibitors A As

Camptothecin Its Derivatives for Cancer Therapy Biopharma PEG

Deletions associated with stabilization of the Top1 cleavage complex in

RNA interacts with topoisomerase I to adjust DNA topology Molecular Cell

Topoisomerase 1 cleavage complex enables pattern recognition and

When combined with tdp1 cells the Cdc48UN complex mutants were

Structures of Top1 poisons and our catalytic inhibitors A The

Top1 W205 and N722 residues are critical for CPTinduced nuclear

CPTinduced formation of ubiquitin TOP1 conjugates in tumor cells I

Role of XPFERCC1 and PARP in parallel pathways for the repair of

PDF Mus81mediated DNA cleavage resolves replication forks stalled by

Molecularmechanisms underlying antitumor effects of CPT Download

PARP1 and TDP1 are epistatic for the repair of Top1cc A Survival of

Schematic representation of the CPTbinding site in Top1 A and B

TEX264 drives selective autophagy of DNA lesions to promote DNA repair

AIDinduced decrease in topoisomerase 1 induces DNA structural

Induction of persistent Top1 cleavage complexes Top1cc and

Endogenous mechanisms of stalled TOP1 and TOP2 cleavage complex

Induction of persistent Top1 cleavage complexes Top1cc and

PDF Topoisomerase 1 cleavage complex enables pattern recognition and

The Potential of Topoisomerase InhibitorBased AntibodyDrug Conjugates

TEX264 drives selective autophagy of DNA lesions to promote DNA repair

Dual Processing of RLoops and Topoisomerase I Induces Transcription

Topoisomerase 1DNA complexes are preferentially recognised by a subset

Inhibition of DNAPK prevents Top1 degradation and proteasome activity

ATM is required for the normal response to CPT a topoisomerase 1

Growth rate for eight cell lines and correlation between growth rate

The Clinical Proteomic Technologies for Cancer Details for CPTCTOP1MT1

TEX264 drives selective autophagy of DNA lesions to promote DNA repair

MYC assembles and stimulates topoisomerases 1 and 2 in a topoisome

A hypothetical model summarizing the interplay between PTMs and

Replicationindependent DPC repair mechanisms A Removal of

Figure 1 from Camptothecin CPT and its derivatives are known to

Top1cc

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