Top1cc

Function of Top1cc at the rRFB and link with previously reported DSBs

TOP1cc enhances dsDNA recognition by cGAS a Coimmunoprecipitation

HD patientderived fibroblasts show increased TOP1cc levels after CPT

Stabilization of Top1cc at the eRFB1 A Contribution of Download

Model depicting the parallel actions of Tdp1 and Rad16Swi10 in Top1cc

TOP1PARylation enhances TDP1 recruitment without enhancing TOP1cc

Top1cc enrichment at an eRFB is strandspecific and independent of RF

TOP1cc is required for signaldependent acutely enhancer activation a

F10 and CPTs both form Top1cc but have different outcomes in response

The p97 ATPase promotes TOP1cc repair a RADAR assay to assess TOP1cc

TOP1cc enhances dsDNA recognition by cGAS a Coimmunoprecipitation

Top1cc can arise in the nervous system in response to DNA damage a

Proteasomedependent processing of TOP1cc leads to excess DSB formation

F10 and CPTs both form Top1cc but have different outcomes in response

Top 1 inhibition Top1cc and PARP1 induction and Download

TOP1PARylation enhances TDP1 recruitment without enhancing TOP1cc

TOP1cc is presented at signalinduced active enhancers a Pie chart

TOP1cc enhances dsDNA recognition by cGAS a Coimmunoprecipitation

The p97 ATPase promotes TOP1cc repair a RADAR assay to assess TOP1cc

Stabilization of Top1cc at the eRFB1 A Contribution of Download

HD patientderived fibroblasts show increased TOP1cc levels after CPT

ATM prevents Top1cc accumulation in vivo a Schematic of the in vivo

Stabilization of Top1cc at the eRFB1 A Contribution of Download

TOP1cc enhances dsDNA recognition by cGAS a Coimmunoprecipitation

WRN is a key regulator of TOP1cc removal and NF‐κB activation. (a–c ...

WRN is a key regulator of TOP1cc removal and NFB activation ac

A 450bp rRFB sequence is sufficient to trigger a Top1cc signal outside

FAM111A KO causes trappingdependent PARPi sensitization and TOP1cc

Nterminal domain is essential for in vivo Tdp1 catalysis of TOP1cc

TOP1cc enhances dsDNA recognition by cGAS a Coimmunoprecipitation

TOP1cc is presented at signalinduced active enhancers a Pie chart

The TIP pathway for TOP1cc is independent of active DNA replication

TEX264 cooperates with the metalloprotease SPRTN in TOP1cc repair a

Excision pathways that work in parallel with TDP1 in removing TOP1cc

Nonenzymatic role of WRN in TOP1cc removal a Schematic

TDP1 in vivo catalysis of TOP1cc requires the complete NTD a top1

Nterminal domain is essential for in vivo Tdp1 catalysis of TOP1cc

FAM111A KO causes trappingdependent PARPi sensitization and TOP1cc

Top1cc and AntiCancer Discovery

Top1cc enrichment at an eRFB is strandspecific and independent of RF

HD patientderived fibroblasts show increased TOP1cc levels after CPT

Crossing the border Replication fork adducts move to lysosomes for

TyrosylDNA Phosphodiesterase 1 and Topoisomerase I Activities as

TEX264 drives selective autophagy of DNA lesions to promote DNA repair

Overview of fluorescence cleavage assay A Schematic representation

Replicationindependent DPC repair mechanisms A Removal of

TOP1 and Rloops facilitate transcriptional DSBs at hypertranscribed

TOP1DNA trapping by exatecan and combination therapy with ATR

Deletions associated with stabilization of the Top1 cleavage complex in

Scheme of yeast screening assay for human TOP1 inhibitors that act as

TEX264 drives selective autophagy of DNA lesions to promote DNA repair

Scheme of yeast screening assay for human TOP1 inhibitors that act as

Top1ccs accumulate at the rRFB A Mapping of Top1 in the rDNA by

TEX264 drives selective autophagy of DNA lesions to promote DNA repair

Substitution of nucleoside analogs into a model Top1 cleavage site

TEX264 drives selective autophagy of DNA lesions to promote DNA repair

Topoisomerase 1DNA complexes are preferentially recognised by a subset

The Potential of Topoisomerase InhibitorBased AntibodyDrug Conjugates

Dual Processing of RLoops and Topoisomerase I Induces Transcription

Topoisomerase 1 cleavage complex enables pattern recognition and

Endogenous mechanisms of stalled TOP1 and TOP2 cleavage complex

RNA interacts with topoisomerase I to adjust DNA topology Molecular Cell

Schematic representation of our findings regarding the Top1 dynamics in

Patulin and Xestoquinol are inhibitors of DNA topoisomerase 1 PNAS

TOP1 and Rloops facilitate transcriptional DSBs at hypertranscribed

A hypothetical model summarizing the interplay between PTMs and

Ube3a unsilencing is TOP1ccdependent A Ube3ampTop1flfl AS

Top1ccs accumulate at the rRFB A Mapping of Top1 in the rDNA by

PDF Topoisomerase I in Human Disease Pathogenesis and Treatments

Gastroenteropancreatic neuroendocrine carcinoma tumor spheroid drug

Scheme 1 Proposed model for TOP1driven base excision repair of

The SprT domain of Spartan is necessary and sufficient to suppress

TEX264 drives selective autophagy of DNA lesions to promote DNA repair

RND1 transcripts are closely associated with the presence of TOP1cc a

Differential involvements of TOP1ccprocessing pathways in CPTinduced

Extrachromosomal DNA replication and maintenance couple with DNA damage

In vitro formation of TOP1ccs in a duplex oligonucleotide DNA

Proposed mechanism of replicationmediated DSB induction by CPT A

Inhibition of Topoisomerase DNA I TOP1 DNA Damage Repair and

Epigenetic control of topoisomerase 1 activity presents a cancer

Induction of persistent Top1 cleavage complexes Top1cc and

TEX264 coordinates p97 and SPRTNmediated resolution of topoisomerase

Distinct actions of topoisomerase poisons and inhibitors A As

Mus81deficient cells are not defective in the removal of Top1cc AC

TOP1cc–Ku70–HP1γ serves as a general transcriptional code underlying ...

TOP1ccKu70HP1 serves as a general transcriptional code underlying

TEX264 drives selective autophagy of DNA lesions to promote DNA repair

Articles Cancer Drug Resistance OAE

Repair of topoisomerase 1induced DNA damage by tyrosylDNA

Replisome Dynamics and Their Functional Relevance upon DNA Damage

RNA interacts with topoisomerase I to adjust DNA topology Molecular Cell

NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1

Topoisomerase 1DNA complexes are preferentially recognised by a subset

Nonenzymatic function of WRN RECQL helicase regulates removal of

Role of WRN in ssDNA generation and nuclear translocation of p65 and

PARP1 and TDP1 are epistatic for the repair of Top1cc A Survival of

TEX264 drives selective autophagy of DNA lesions to promote DNA repair

PARP1 and TDP1 are epistatic for the repair of Top1cc A Survival of

Topoisomerase I in Human Disease Pathogenesis and Treatments Li Liu

Role of XPFERCC1 and PARP in parallel pathways for the repair of

Induction of persistent Top1 cleavage complexes Top1cc and

The Potential of Topoisomerase InhibitorBased AntibodyDrug Conjugates

HP1γ is recruited to signal-dependent acutely activated enhancers by ...

HP1 is recruited to signaldependent acutely activated enhancers by

Differential involvements of TOP1ccprocessing pathways in CPTinduced

PARP1 and TDP1 are epistatic for the repair of Top1cc A Survival of

PDF Mus81mediated DNA cleavage resolves replication forks stalled by

Schematic representation of our findings regarding the Top1 dynamics in

Frontiers Phosphonic acidcontaining inhibitors of tyrosylDNA

Induction of persistent Top1 cleavage complexes Top1cc and

Cellular processing determinants for the activation of damage signals

Repair of topoisomerase 1induced DNA damage by tyrosylDNA

a Scheme depicting the major differences between Top1CCs and

Frontiers Mitochondrial topoisomerase 1 inhibition induces

The action of topoisomerase I TOP1 poison inhibitors and role of

TEX264 drives selective autophagy of DNA lesions to promote DNA repair

TyrosylDNA Phosphodiesterase 1 and Topoisomerase I Activities as

Substitution of nucleoside analogs into a model Top1 cleavage site

Top1cc Radar Assay Working Flow

Ikona Top1

Top1 Inhibition

Top1 Shirt

Top1 Staining Nucleus

Trapped Top1 and Endonuclease

Top1 Binding Quadruplex

Topcc Gene

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