+mechanisms+involved+in+induced+leptin+expression+in+trophoblastic+cells.+E2+action+involves+nuclear+and+membrane-associated+estrogen+receptor+alpha+(ER%CE%B1).+The+activation+of+several+signaling+pathways+in+response+to+E2+regulates+leptin+expression.+Another+transcription+factor+(TF)+could+also+be+involved.+Source:+Reprinted+with+permission+from+Ref.+370..jpg)
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