Ubqln2

PDF Key role of UBQLN2 in pathogenesis of amyotrophic lateral

UBQLN2 in neurodegenerative disease mechanistic insights and emerging

UBQLN2 Wikipedia

Ubiquitin Modulates LiquidLiquid Phase Separation of UBQLN2 via

Model of changes in fulllength UBQLN2 conformational state as a

Generation and characterization of the UBQLN2 P497H iPSC line using

Mutant UBQLN2 promotes toxicity by modulating intrinsic selfassembly

UBQLN2 Antibody Cell Signaling Technology

UBQLN2 Mediates AutophagyIndependent Protein Aggregate Clearance by

Downregulation of UBQLN2 in hypoxia induces apoptosis in human

UBQLN2 level influences the expression of TIA1 A B After SA

Disease Mutant UBQLN2 Loses Binding to HSP70 and Sensitizes to Protein

Mutations in UBQLN2 cause dominant Xlinked juvenile and adultonset

Disrupting the Balance of Protein Quality Control Protein UBQLN2

UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration

Mutant UBQLN2 promotes toxicity by modulating intrinsic selfassembly

Overexpression of UBQLN2 results in dosedependent retinal

Ubiquitin Modulates LiquidLiquid Phase Separation of UBQLN2 via

Among brainexpressed ubiquilins UBQLN2 preferentially interacts with

UBQLN2 inclusions were dynamic a Immunofluorescence of GFPlabeled

Visual detection of UBQLN2 in autophagosomes A Fluorescent YFP

UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain

UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration

Colocalization of UBQLN2 and serpin proteins in autophagosomes

UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain

Disrupting the Balance of Protein Quality Control Protein UBQLN2

Ubiquitin Modulates LiquidLiquid Phase Separation of UBQLN2 via

Mutant UBQLN2 promotes toxicity by modulating intrinsic selfassembly

Disrupting the Balance of Protein Quality Control Protein UBQLN2

UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration

UBQLN2 mutations induce pathologic disturbances in autophagy in humans

Disrupting the Balance of Protein Quality Control Protein UBQLN2

Phase separation of polyubiquitinated proteins in UBQLN2 condensates

AAV expression of UBQLN2 WT and mutants is specific to neurons Images

UBQLN2 and serpin proteins form aggregates in P497S animals in an

UBQLN2 Wikipedia

Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and

UBQLN proteins in health and disease with a focus on UBQLN2 in ALSFTD

Figure S2 Puromycin Does Not Upregulate UBQLN2 Levels and UBQLN2

Ubiquitin Modulates LiquidLiquid Phase Separation of UBQLN2 via

Disrupting the Balance of Protein Quality Control Protein UBQLN2

ALSFTD mutations in UBQLN2 impede autophagy by reducing autophagosome

Model of How UBQLN2 Manages Proteotoxic Stress Download Scientific

Proteasome subunits in protein aggregates of the UBQLN2 P497H

The expression level of UBQLN2 protein in esophageal squamous cell

UBQLN2 expression in Neuro2A cells caused cellular stress via MAP

UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration

Disrupting the Balance of Protein Quality Control Protein UBQLN2

The expression of Ubqln2 has positive associations with proliferation

UBQLN1 UBQLN2 and UBQLN4 exhibit different phase behaviors A Domain

Model of changes in fulllength UBQLN2 conformational state as a

Prognostic and predicted significance of Ubqln2 in patients with

UBQLN2 Mediates AutophagyIndependent Protein Aggregate Clearance by

UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration

ALSlinked mutations impair UBQLN2 stressinduced biomolecular

Ubiquitin Modulates LiquidLiquid Phase Separation of UBQLN2 via

ALSLinked Mutations Affect UBQLN2 Oligomerization and Phase Separation

UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration

UBQLN2 Mediates AutophagyIndependent Protein Aggregate Clearance by

ALSlinked mutations impair UBQLN2 stressinduced biomolecular

UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration

Expression of mutant Ubqln2 in rats interfered with endosome pathways

Phase separation of polyubiquitinated proteins in UBQLN2 condensates

UBQLN2 and HSP70 participate in Parkinmediated mitophagy by

Ubiquitin Modulates LiquidLiquid Phase Separation of UBQLN2 via

UBQLN2 Mediates AutophagyIndependent Protein Aggregate Clearance by

Phase separation of polyubiquitinated proteins in UBQLN2 condensates

The expression of Ubqln2 has positive associations with proliferation

UBQLN2 antibody 234491AP Proteintech

Proteasome subunits in protein aggregates of the UBQLN2 P497H

UBQLN2 Monoclonal Antibody 5F5 Invitrogen H00029978M03

UBQLN2 Mutations Do Not Cause Protein Aggregation A Inducible HEK293

Cell atlas UBQLN2 The Human Protein Atlas

UBQLN2 Mediates AutophagyIndependent Protein Aggregate Clearance by

UBQLN2 undergoes a reversible temperatureinduced conformational switch

ALSLinked Mutations Affect UBQLN2 Oligomerization and Phase Separation

Phase separation of polyubiquitinated proteins in UBQLN2 condensates

UBQLN2 inclusions were dynamic a Immunofluorescence of GFPlabeled

Projects Alexandra Whiteley Laboratory University of Colorado Boulder

Schematic representation of the domain architecture of the human

Ubiquilin 2 modulates ALSFTDlinked FUSRNA complex dynamics and

TANKbinding kinase 1 TBK1 interacts with Ubiquilin 2 UBQLN2 AB

Ubiquilin 2 Shuttling Clients Out of Phase Molecular Cell

Castañeda Lab – Biochemistry and Biophysics at SU

Castaeda Lab Biochemistry and Biophysics at SU

We condense if we want to We cant leave AZUL outside Structure

A Schematic representation of ubiquilin2 protein indicating

Ubiquilin 2 modulates ALSFTDlinked FUSRNA complex dynamics and

Ubiquilin 2 enhances osteosarcoma progression through resistance to

Ubiquilin 2 modulates ALSFTDlinked FUSRNA complex dynamics and

Ubiquilin2 regulates pathological alphasynuclein PMC

Microscopic C9ORF72 pathology in a pathological AD case Ubiquitin

Stereoview of superimposed structures of the UBL domain of ubiquilin 2

Oncology Reports

Ubiquilin2 antibody screening by immunofluorescence HAP1 wildtype

Ubiquilin 2 enhances osteosarcoma progression through resistance to

Ubiquilin 2 modulates ALSFTDlinked FUSRNA complex dynamics and

Ubiquilin2 regulates pathological alphasynuclein PMC

Liquid-Liquid Phase Separation in Protein Quality Control – Castañeda Lab

LiquidLiquid Phase Separation in Protein Quality Control Castaeda Lab

Structural organization of human ubiquilins UBQLNs The figure

Ubiquilin 2 modulates ALSFTDlinked FUSRNA complex dynamics and

Distribution of ubiquilin 2 and TDP43 aggregates throughout the CNS in

TANKbinding kinase 1 TBK1 interacts with Ubiquilin 2 UBQLN2 AB

LiquidLiquid Phase Separation in Protein Quality Control Castaeda Lab

Ubiquilin2 regulates pathological alphasynuclein PMC

Ubiquilin 2 modulates ALSFTDlinked FUSRNA complex dynamics and

ALS

TANKbinding kinase 1 TBK1 interacts with Ubiquilin 2 UBQLN2 AB

Solution structure of pUbRL in complex with Ubqln2UBA PDB code 7F7X

Global proteomics of Ubqln2based murine models of ALS Journal of

Partial loss of MYC reverses increased cell migration following loss of

Structural organization of human ubiquilins UBQLNs The figure

UBQLN2HSP70 axis reduces polyGlyAla aggregates and alleviates

The genomic landscape of HCC and mutational signatures A The

Distribution of ubiquilin 2 and TDP43 aggregates throughout the CNS in

Ubiquitin Protein OTUB SUMO UBL USP RPS27A ProSpec

Global proteomics of Ubqln2based murine models of ALS Journal of

Mosaic Ubqln2

Ubiquitination

Mutations in the Ubqln2 Gene

Protein Aggregation

TBK1 Phosphorylation

Ubqln2 Structure

Ubqln2 Domain Structure

Fluorescence Microscopy ER

Ubiquitin N Tubes

Liquid Phase Separation

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