Trp53

Mutant p53 promotes ESCC invasion and lung metastasis A left Trp53

TRP53 activates a global autophagy program to promote tumor suppression

Combined scheme showing irradiationinduced Trp53 molecular signalling

a Schematic representation of Trp53 genetargeting strategy Red

Cell of Origin of Small Cell Lung Cancer Inactivation of Trp53 and Rb1

Trp53 is as a target of miR1385p in the metastatic 4C11 cells A

A Immunohistochemical staining of TRP53 in the placental labyrinth

a Schematic representation of Trp53 genetargeting strategy Red

Generation of Trp53 Brca1 ID8 cells A Design of guide RNA

Trp53 controls chondrogenesis and endochondral ossification by negative

Mammaryspecific expression of mutant Trp53 in an Amphiregulin knockout

Introduction of Trp53 mutations in Nbs1deficient brain largely rescues

Trp53 Deletion Promotes Exacerbated Colitis Facilitates Lgr5 Cancer

Mutant TRP53 proteins exert a target geneselective DNE A

Preneoplastic Trp53 mammary organoids mimic features of Trp53

Cremediated recombination of floxed Trp53 alleles affects the majority

Trp53 inactivation rescues apoptosis morphological defects and visual

Mutant TRP53 proteins exert a target geneselective DNE A

Mutant TRP53 exerts a target geneselective dominantnegative effect to

Increased genomic instability in Rb1 DLDL Trp53 thymic lymphoma

Expression of Trp53 mRNA within preimplantation stage embryos RTPCR

Generation of Trp53 Nf1 and Trp53 Pten ID8 cells A

Targeting the TRP53 binding site in the Nprl3 promoter accelerates

Trp53 R172H not wildtype p53 binds to YAP and fosters Survivin

Trp53 inactivation rescues apoptosis morphological defects and

Genetic Inactivation of Notch1 Synergizes with Loss of Trp53 to Induce

TRP53 CRISPR Knockout ID8Luciferase Stable Cell LineT12 Applied

The Trp53 R270 mutant allele mediates alterations in expression levels

Unbiased sequencing analyses identify Trp53 mutation as critical

A Relative mRNA expression levels of Trp53 and Pten at 48 72 and 96

Trp53 is a crucial sensor of cellular stress and a guardian of the

Eftud2 ncc Trp53 ncc embryos have decreased P53 activity and

Deletion of Trp53 is unable to rescue the phenotypes observed in Dicer

Epistatic interactions between NMD and TRP53 control progenitor cell

Trp53 Deletion Promotes Exacerbated Colitis Facilitates Lgr5 Cancer

Depletion of Trp53 and Cdkn2a Does Not Promote SelfRenewal in the

Mutant Trp53 accelerates BRAFV600Edriven melanomagenesis a Trp53

The hot spot mutant TRP53 proteins R246Q and R270H selectively

ISMARA results Trp53

Synthetic Trp53 integration via mSwAPIn a p53 mutation hotspots and

Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity

p53 haploinsuff ciency and susceptibility to Trp53 LOH and carcinogen

Trp53 controls chondrogenesis and endochondral ossification by negative

Trp53 deficiency protects against acute intestinal inflammation

a Trp53 expression in undifferentiated ES cells OCRG9 ES cells

Trp53 is a crucial sensor of cellular stress and a guardian of the

Conditional deletion of Cdh1 and Trp53 drives tumor development in

Loss of one Trp53 allele affects NF-κB pathway via regulation of IκBα ...

Loss of one Trp53 allele affects NFB pathway via regulation of IB

Trp53 modulates chondrogenesis and endochondral ossification through

The Trp53 delta proline (Trp53ΔP) mouse exhibits increased genome ...

The Trp53 delta proline Trp53P mouse exhibits increased genome

Trp53 Mutation in Keratin 5 Krt5Expressing Basal Cells Facilitates

Trp53 72P activates Trp53dependent DNArepair target gene promoters

The Trp53 delta proline Trp53P mouse exhibits increased genome

Notch1 and Trp53 deletion in Hes5 cells leads to formation of

Depletion of Trp53 and Cdkn2a Does Not Promote SelfRenewal in the

Trp53 and Rb1 regulate autophagy and liganddependent Hedgehog

Cas9-mediated editing of Trp53 in Arf À/À Em-myc lymphomas is ...

Cas9mediated editing of Trp53 in Arf Emmyc lymphomas is

Combined mutation of Vhl and Trp53 causes renal cysts and tumours in

Combined mutation in Vhl Trp53 and Rb1 causes clear cell renal cell

Genetic Inactivation of Notch1 Synergizes with Loss of Trp53 to Induce

Trp53 Mutation in Keratin 5 Krt5Expressing Basal Cells Facilitates

Loss of Trp53 is sufficient to induce GBM with high penetrance A

Trp53 mutation increases spheroid viability and growth A Schematic

Trp53 Haploinsufficiency Modifies EGFRDriven Peripheral Nerve Sheath

TRP53 amplification in mouse embryo stage E115 Amplification

The Trp53 delta proline Trp53P mouse exhibits increased genome

Trp53 Deletion Promotes Exacerbated Colitis Facilitates Lgr5 Cancer

Deletion of Trp53 and Rb1 increases the expansion and differentiation

Preneoplastic Trp53 mammary organoids mimic features of Trp53

CRISPRCas9mediated gene disruption of Trp53 in WEA and WEP cancer

Depletion of BIRC5 attenuates Trp53 R172H driven lung metastasis

Loss of Trp53 results in a hypoactive T cell phenotype accompanied by

Wnt 诱导的、TRP53 介导的细胞周期停滞是衰老过程中 Cajal 耗竭的间质细胞的基础。,Cellular and Molecular ...

Wnt TRP53 Cajal Cellular and Molecular

A model for the Trp53mediated downregulation of Notch signaling The

Human TP53 gene known RNA transcripts and protein isoforms a

TP53

The Trp53Trp53inp1Tnfrsf10b Pathway Regulates the Radiation Response

The genomic organization of the human and mouse p53 gene A Both the

In the absence of Trp53 PtenKras OSE cells are transformed yet do not

Induction of small cell lung cancer by somatic inactivation of both

p53 status in TR and TRP L tumors and cortex A Representative images

Trp53QS binds DNA constitutively and its subcellular localization is

On the role of p53 in the cellular response to aneuploidy Cell Reports

A Trp53 tissues recombinant showing normal prostate gland with

ATRIP loss leads to TRP53mediated cell death in embryonic lens

The pathogenesis of therapyrelated myeloid neoplasms from TP53mutant

Differentiation of Trp53null ES cells in twodimensional culture

p53mediated regulation of epiblast cell numbers predicts reactivation

A schematic illustration of the for TP53Trp53 mutation and metastasis

Direct in vivo editing of Prkar1aTrp53 or Axin1Trp53 genes in the

Sequencing of the Mastomys p53 gene Trp53 and partial alignment with

Wntinduced TRP53mediated Cell Cycle Arrest of Precursors Underlies

Anaplastic phenotype and clonal architecture through Trp53loss in

Disrupted control of origin activation compromises genome integrity

A schematic illustration of the for TP53Trp53 mutation and metastasis

A Trp53 tissues recombinant showing normal prostate gland with

p53loss induced prostatic epithelial cell plasticity and invasion is

Deletions linked to TP53 loss drive cancer through p53independent

Trp53 FAP transplantation impairs muscle regeneration after acute

OSEisolated cells from PtenKrasTrp53 and PtenKrasTrp53 mice are

Freshly isolated Trp53 ah and Trp53 ip primary mMECs were

PTEN loss drives p53 LOH and immune evasion in a novel urothelial

Verteporfin Inhibits the Progression of Spontaneous Osteosarcoma Caused

Brca2Trp53 mutants have increased DNA damage and apoptosis A

Regulation of male germline transmission patterns by the Trp53Cdkn1a

Figure 3 from Loss of Rad51c leads to embryonic lethality and

P53 Mutation Induces EpithelialtoMesenchymal Transition EMT

Spinal motor neuron loss occurs through a p53andp21independent

Regulation of male germline transmission patterns by the Trp53Cdkn1a

PtenTrp53 double knockout tumors have EMTlike characteristics A

Trp53dependent endogenous DNArepair target genes are activated more

Oncogenic and teratogenic effects of Trp53Y217C an inflammationprone

ECTrp53 deletion inhibits EndMT vascular abnormality and KP tumour

Wntinduced TRP53mediated Cell Cycle Arrest of Precursors Underlies

Distinct oncogenic phenotypes in hematopoietic specific deletions of

TLs from Trp53 Nucks1 mice infiltrate distant organs more

A schematic illustration of the for TP53Trp53 mutation and metastasis

Chemosensitivity to doxorubicin in primary cells derived from tumor of

The Trp53Trp53inp1Tnfrsf10b pathway regulates the radiation response

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