Smarca2 Complex

PROTACmediated ternary complex formation between SMARCA2 and the E3

Complex Alternative Splicing of the Smarca2 Gene Suggests the

PDF Complex Alternative Splicing of the Smarca2 Gene Suggests the

RCSB PDB 9AYQ SMARCA2 in complex with a pyridine2onebased inhibitor

RCSB PDB 9D11 Smarca2 Bromodomain in complex with compound 22

Complex alternative splicing of the smarca2 gene suggests the

RCSB PDB 9D12 Smarca2 Bromodomain in complex with compound 15

SMARCA2 Prelude Therapeutics

De novo SMARCA2 variants clustered outside the helicase domain cause a

Enhancer reprogramming underlies therapeutic utility of a SMARCA2

Discovery of Novel Selective Inhibitors of SMARCA2 ATPase Domain by

Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by

Expression pattern of SMARCA2 during porcine ovarian follicular

Most populated structures of SMARCA2 bound to VHL with different

Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by

RCSB PDB 7Z78 Crystal structure of compound 4 in complex with the

Preclinical Programs CDK9 SMARCA2 38Preclinical Programs CDK9 SMARCA238

SMARCA2 silencing in SCCOHT tumours and cell lines and reactivation by

Concomitant loss of SMARCA2 and SMARCA4 expression in small cell

Heterogeneous expression pattern of SMARCA2 and PDL1 in Download

RNAi and proteomic screens identify SMARCA2 as potential MxA cofactor

Transcriptome changes associated with SMARCA4 or SMARCA2 upregulation

Discovery of SMD3040 as a Potent and Selective SMARCA2 PROTAC Degrader

Expression pattern of SMARCA2 during porcine ovarian follicular

Biochemical and genomic characterization of a residual complex in

Immunohistochemistry for SMARCA2 and SMARCA4 in formalinfixed

Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by

A947 is a Selective and Efficacious SMARCA2 PROTAC in SMARCA4 Mutant

RCSB PDB 8QJT BRM SMARCA2 Bromodomain in complex with ligand 10

Summary of SMARCA2 and SMARCA4 mutation and immunohistochemistry status

A947mediated SMARCA2 degradation synergizes with MCL1 inhibition a

Lowlevel germline mosaicism of a novel SMARCA2 missense variant

SMARCA2 Assay A Validated HTS Inhibitor Screening Assay

Correlation between SMARCA4 or SMARCA2 expression levels and

SMARCA2 PROTAC ACBl2 opnMe Boehringer Ingelheim

Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by

AlphaLISA SureFire Ultra Human Total SMARCA2 Detection Kit 100 Assay

Reexpression of SMARCA4 or SMARCA2 suppresses SCCOHT cell growth A

Structure Based SMARCA2 PROTAC Design YouTube

Aberrant SWISNF Complex Members Are Predominant in Rare Ovarian

Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by

SWISNF chromatin remodeling complex and glucose metabolism are

RCSB PDB 8QJT BRM SMARCA2 Bromodomain in complex with ligand 10

Enhancer reprogramming underlies therapeutic utility of a SMARCA2

Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by

Enhancer reprogramming underlies therapeutic utility of a SMARCA2

Baf Chromatin Remodeling Complex VBHWI

Genotype and phenotype correlation in epilepsy patients with SMARCA2

PDF Selective PROTACmediated degradation of SMARCA2 is efficacious

PDF A twofaced selectivity solution to target SMARCA2 for cancer therapy

Discovery of Novel Potent and Orally Bioavailable SMARCA2 Proteolysis

SWISNF ATPases SMARCA2 and SMARCA4 mediate chromatin accessibility

Enhancer reprogramming underlies therapeutic utility of a SMARCA2

Immunohistochemistry for SMARCA2 and SMARCA4 in formalinfixed

SMARCA2 Assay A Validated HTS Inhibitor Screening Assay

Slide 31

SMARCA2蛋白：药物设计的结构、功能和前景,European Journal of Medicinal Chemistry - X-MOL

SMARCA2European Journal of Medicinal Chemistry XMOL

Frame stack representing the path collective variable PCV for the

Human Genetics and Genomics Advances Human Genetics and Genomics Advances

A selective and orally bioavailable VHLrecruiting PROTAC achieves

Frontiers SWISNF chromatin remodelers in prostate cancer progression

SMARCA2 PROTAC

DNA repair goes hiphop SMARCA and CHD chromatin remodellers join the

Mechanistic dissection of SMARCA24 molecular glues reveals

Figure 3 from The SMARCA24 ATPase Domain Surpasses the Bromodomain as

Identification of proteomic landscape of drugbinding proteins in live

SMARCA24 expression in ARMS ERMS primary tumors and cell lines A

Application of Selective SMARCA24 PROTAC for Mutant Cancer Therapy

PRT3789 Is a FirstinHuman SMARCA2Selective Degrader That Induces

Discovery of HighAffinity SMARCA24 Bromodomain Ligands and

Downregulation of SMARCA4 drives the observed switch to SMARC2 in the

SMARCA2SMARCA4

Preclinical Characterization of SMARCA2Selective Monovalent Direct

Comprehensive Analysis of Protein Dynamics Using HiBiT Tagging

Chromatin remodeling SWISNF complexes cancer and response to

a Conformational free energy landscape as a function of the first two

Slide 36

The transcription factor GLI1 cooperates with the chromatin remodeler

Figure 6 from The SMARCA24 ATPase Domain Surpasses the Bromodomain as

RCSB PDB 9HYP CRYSTAL STRUCTURE OF THE SMARCA2VCBCOMPLEX WITH

A selective and orally bioavailable VHLrecruiting PROTAC achieves

Mechanistic dissection of SMARCA24 molecular glues reveals

Targeting SMARCA2Dependent SOX2 Condensates Suppresses Lung

Frontiers Mutational Landscapes and Phenotypic Spectrum of SWISNF

Probing the contribution of PPIs to cooperativity a PPIs in the

RCSB PDB 9HYN CRYSTAL STRUCTURE OF THE SMARCA2VCBCOMPLEX WITH

Mammalian SWISNF chromatin remodeling complexes promote tyrosine

RCSB PDB 9HYN CRYSTAL STRUCTURE OF THE SMARCA2VCBCOMPLEX WITH

RCSB PDB 9DU0 Crystal structure of the bromodomain of human BRM

Long noncoding RNA UCA1 modulates SMARCA2containing SWISNF chromatin

The SMARCA24 ATPase Domain Surpasses the Bromodomain as a Drug Target

SMARCA2 PROTAC

smarca2 tpd targetedproteindegradation protac crbn smarca2

DNA repair goes hiphop SMARCA and CHD chromatin remodellers join the

Clinicopathological and molecular perspectives on thoracic SMARCA4

SMARCA2 PROTAC

SMARCA24 expression in ARMS ERMS primary tumors and cell lines A

Dundee and Boehringer Ingelheim scientists degrade undruggable cancer

Frontiers Case Report FAP fibroblasts and SPP1 macrophages in

Immunohistochemical analysis of SMARCA4BRG1 and SMARCA2BRM in ovarian

Slide 33

RCSB PDB 9DU0 Crystal structure of the bromodomain of human BRM

Long noncoding RNA UCA1 modulates SMARCA2containing SWISNF chromatin

SMARCA2 PROTAC

SMARCA2SMARCA4

SMARCA2regulated host cell factors are required for MxA restriction of

PDF Involvement of SMARCA2BRM in the SWISNF chromatinremodeling

Clinicopathological characterization of SwitchSucrosenonfermentable

ACBI1 is a potent and selective degrader of SMARCA2 SMARCA4 and

SMARCA2 PROTAC

Frontiers SWISNF chromatin remodelers in prostate cancer progression

开关/蔗糖不可发酵 (SWI/SNF) 复合物 (SMARCA4、SMARCA2、INI1/SMARCB1) 缺陷型结直肠癌与微卫星不稳定性 ...

SWISNF SMARCA4SMARCA2INI1SMARCB1

Smarca2 Inhibitor

Smarca D1 Smarca2 Protein Complex

ProTac Ternary Complex

Smarca2 Structure

Smarca2 Immunofluorescence

Smarca2 HDAC

Smarca2 Proteasome

Smarca2 Genetic Disorder

Smarca2 Molecular Glue

Smarca2 and 4 ATP Hydrolysis

Smarca2 Sequence Diagram

Smarca Degrader Proteomics

Smarca4 Gene Mutation

Smarca4 Splicing Mutation

VHL E3 Ligase Complex

Smarca2 Hibit Cell Line

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