Sos1

Diagramatic representation of SOS1 structure The diagram was drawn

Fig S4 Structural analysis of SOS1 mutations A Crystal structures

SOS1 domain structure and location of affected residues in NS ASOS1

RBDs inhibit fulllength SOS1 by preventing its allosteric activation

Transformants Overview A Comparison of WT and sos1 sequences sos1

SHP2 and SOS1 Targets Additional Players in the KRAS Inhibitors Race

A Schematic of human SOS1 protein with our patients variant indicated

Identification and characterization of oncogenic SOS1 mutations in lung

A SOS1 alters mitochondria morphology mass and dynamics SOS1

SOS1 mutations are significantly associated with cancer and activate

Changes in relative mRNA expression of SOS1 in leaves of broad bean

A transcriptional recognition site within SOS1 coding region controls

SOS1 Laboratory Testing and Research

SOS1 Antibody Cell Signaling Technology

Optimal activity of membranetargeted SOS1 depends on RasGRP1 function

Sos1Ras complex highlighting specificity regions helix B of Sos1 and

SOS1 GainofFunction Variants in Dilated Cardiomyopathy Circulation

SOS1 Gene GeneCards SOS1 Protein SOS1 Antibody

Expression and characterization of various length SOS1 proteins a

The Arabidopsis thaliana salt tolerance gene SOS1 encodes a putative

Inverse regulation of SOS1 and HKT1 protein localization and stability

SOS1 is the second most common Noonan gene but plays no major role in

Frontiers Genomewide characterization of SOS1 gene family in potato

SOS1 domain structure and location of affected residues in NS ASOS1

SOS1 Gene GeneCards SOS1 Protein SOS1 Antibody

SOS1 is upregulated in RUNX1 highexpressing gastric cancers ab

SOS1 safeguards plant circadian rhythm against daily salt fluctuations

SOS1 Laboratory Testing and Research

Sos1 expression is preferentially maintained upon RasGRP1 deletion

EGF receptor uses SOS1 to drive constitutive activation of NFκB in ...

EGF receptor uses SOS1 to drive constitutive activation of NFB in

Molecular architecture of SOS1 a The 3D structure of SOS1 is shown

SOS1 gene Semantic Scholar

PTPN11 and SOS1 gainoffunction variants in the RasMAPK pathway and

SOS1 Gene Clear Bridge BiOMEDICS

Inverse regulation of SOS1 and HKT1 protein localization and stability

Diagramatic representation of SOS1 structure The diagram was drawn

Inverse regulation of SOS1 and HKT1 protein localization and stability

Membrane localization of the Arabidopsis SOS1 protein Microsomal

SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant

CycC11WRKY75 complexmediated transcriptional regulation of SOS1

3D model of SOS1 wild type and its R552G mutant A Green wild type

Seeing how SOS1 works in response to salt stressInstitute of Genetics

Sos1 is a downstream target of Abl and Srcfamily kinases A COS7

SOS1 inhibition synergizes with the EGFRTKI inhibitor osimertinib to

Sos1 protein interacts with the multiprotein complex COP9 signalosome

Multiple Sos1 functions are required for optimal preTCRdependent

Inverse regulation of SOS1 and HKT1 protein localization and stability

Targeted Sos1 deletion reveals its critical role in early Tcell

SOS1 inhibition synergizes with mutant EGFR inhibition to inhibit

SOS1 GainofFunction Variants in Dilated Cardiomyopathy Circulation

Architecture of Arabidopsis thaliana SOS1 a b Overall structure of the

Proposed molecular mechanism by which p66shc switches sos1 from a ras

开发基于 SOS1 抑制剂的降解剂以靶向 KRAS 突变结直肠癌,Journal of Medicinal Chemistry - X-MOL

SOS1 KRAS Journal of Medicinal Chemistry XMOL

Discovery of potent SOS1 inhibitors that block RAS activation via

SOS1 is similar to Na H antiporters A Alignment of SOS1 accession

Frontiers Genomewide characterization of SOS1 gene family in potato

In vitro experiments demonstrate the involvement of SOS1 in the

PDF Discovery of potent SOS1 inhibitors that block RAS activation via

Evolutionary relationships of 14 SOS1 protein sequences inferred using

RUNX1 directly transactivates SOS1 expression a Proximal regulatory

SOS1 expression is upregulated by NaCl stress and is under the control

Expression and characterization of various length SOS1 proteins a

Targeted Sos1 deletion reveals its critical role in early Tcell

Design and Structural Optimization of Orally Bioavailable SOS1

Discovery of potent SOS1 inhibitors that block RAS activation via

Sos1 expression is preferentially maintained upon RasGRP1 deletion

SOS1 increases Snail expression and induces EMT through AKTindependent

Hereditary gingival fibromatosis a case report with a novel SOS1

SOS1 mutations in Noonan syndrome molecular spectrum structural

Targeting SOS1 overcomes imatinib resistance with BCRABL independence

Epigenetic and posttranscriptional modulation of SOS1 can promote

SOS1 Laboratory Testing and Research

SOS1 GainofFunction Variants in Dilated Cardiomyopathy Circulation

Differential allelic expression of SOS1 and hyperexpression of the

Discovery of the FirstinClass AgonistBased SOS1 PROTACs Effective in

Inverse regulation of SOS1 and HKT1 protein localization and stability

Targeted Degradation of SOS1 Exhibits Potent Anticancer Activity and

Critical Requirement of SOS1 for Development of BCRABLDriven Chronic

SOS1

The Plant CellSOS1

Helical peptides targeting the RasSOS1 interaction Crystal structure

Son of sevenless 1 (SOS1), the RasGEF, interacts with ERα and STAT3 ...

Son of sevenless 1 SOS1 the RasGEF interacts with ER and STAT3

SOS1compound 1 cocrystal structure SAR and crystal structure of

中国农业大学生物学院科研进展 PLANT CELL | 郭岩团队发现SOS1的负调控元件——PP2C D6/D7

PLANT CELL SOS1PP2C D6D7

Discovery of a Potent Dual Son of Sevenless 1 SOS1 and Epidermal

SOS1

Interaction Domains of Sos1Grb2 Are Finely Tuned for Cooperative

Scheme of the SOS signaling pathway for the regulation of Na

Sos pathway emerging new roles PPTX

SOS1

Rational Design of Small Molecule Inhibitors Targeting the Ras GEF

Interaction Domains of Sos1Grb2 Are Finely Tuned for Cooperative

科学网—《自然—植物》：陈宇航团队解析水稻盐胁迫响应关键分子Na+/H+转运蛋白SOS1的激活机制 - 小柯生命的博文

NaHSOS1

Different molecular recognition by three domains of the fulllength

Helical peptides targeting the RasSOS1 interaction Crystal structure

Interaction Domains of Sos1Grb2 Are Finely Tuned for Cooperative

Journal of Medicinal Chemistry Vol 66 No 7 ACS Publications

Son of sevenless 1 SOS1 the RasGEF interacts with ER and STAT3

Activation of the plasma membrane NaH antiporter SaltOverlySensitive

A salt stressactivated GSO1SOS2SOS1 module protects the Arabidopsis

Activation of the plasma membrane NaH antiporter SaltOverlySensitive

Basal DAG RasGRP1 signaling is required for optimal SOS1cat

SOS1

Interaction Domains of Sos1Grb2 Are Finely Tuned for Cooperative

Reconstitution in yeast of the Arabidopsis SOS signaling pathway for

Activation of the plasma membrane NaH antiporter SaltOverlySensitive

Son of sevenless 1 SOS1 the RasGEF interacts with ER and STAT3

SOS1

Son of sevenless 1 SOS1 the RasGEF interacts with ER and STAT3

Signaling Interplay in Ras Superfamily Function Current Biology

Small MoleculeMediated Activation of RAS Elicits Biphasic Modulation

Activation of the plasma membrane NaH antiporter SaltOverlySensitive

P66shc promotes the formation of the sos1eps8e3b1 complex and

SPARK案例 | 拜尔发现通过干扰RAS-SOS1相互作用能够阻断RAS激活的SOS1抑制剂

SPARK RASSOS1RASSOS1

Multiple Decisive Phosphorylation Sites for the Negative Feedback

SOS1

Bi3406 SOS1 Inhibitor

Kras Signaling Pathway

SOS1 Protein Function

ERK Pathway

SOS1 Protein Mechanism

SOS1 Asurity

SOS1 Phase Separation

Bi3460 SOS1 Inhibitor

SOS1 Na

SOS1 Full Length

SOS1 Gene Noonan

Bi1701963 SOS1 Inhibitor

Ras Activation

SOS1 Inhibitor Review

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