Pvhl19 Localization

Localization of pVHL during mitosis A Cells were costained with

Subcellular localization of pVHL19 pVHL was immunoprecipitated with

Identification of pVHL19 in vivo A 786O VHL renal carcinoma cells

pVHL19 is a biologically active product of the von HippelLindau gene

Identification of pVHL19 in vivo A 786O VHL renal carcinoma cells

Subcellular localization of pVHL in transgenic Download Scientific

pVHL19 is a biologically active product of the von HippelLindau gene

Microtubule alterationmediated pVHL subcellular localization

The subcellular localization of pVHL 30 is not affected by GSK3 A

Identification of pVHL19 in vivo A 786O VHL renal carcinoma cells

pVHL interacts with MDM2 is an isoformspecific manner A Left panel

Cytoplasmic localisation of endogenous pVHL relies on an intact

Lentivirally mediated reexpression of pVHL rescues the ciliadefective

Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in ...

Structure of an HIF1pVHL Complex Hydroxyproline Recognition in

pVHL is localized to renal monocilia a Colocalization of pVHL and

pVHL mutants are categorized as Class A B and C depending on the

3D representative structures from MD simulations A VBC complex

The structure of the pVHLHIF1a red complex PDB ID 1LM8 The pVHL

Genetics Pathophysiology and Current Challenges in Von HippelLindau

The VHLaK protein interacts with pVHL through its KRABA domain A

pVHL attenuates MT growth rate A RPE1 cell system and depletion of

Endogenous pVHL regulates MT stability in a primary cell line A

pVHL induces nuclear retention of pre40S ribosomal subunits A and B

Schematic overview of functions of pVHL Download Scientific Diagram

Prediction of pVHLCDKN1 interactions Proteinprotein interaction

Overview of pVHL functions in four different scenarios In normoxia

pVHL30 but not pVHL19 is phosphorylated A 293T cells were

Endogenous pVHL regulates MT stability in a primary cell line A

Lentivirally mediated reexpression of pVHL rescues the ciliadefective

Function of protein VHL in the proteasome pVHL is thought to function

Immunodetection of endogenous pVHL isoforms in tumour tissues A

Schematic overview of functions of pVHL Download Scientific Diagram

Schematic role of pVHL in HIFpathway pVHL is the critical part of an

AHeLa cells were synchronized as described in Materials and Methods

Analysis of the activity that promotes interaction of HIF with pVHL

Immunodetection of endogenous pVHL isoforms in tumour tissues A

Mechanisms of tumor suppression by pVHL a Model of pVHLmediated

Hypoxiainduced downregulation of pVHL via the ubiquitinproteasome

pVHL expression in VHLdeficient cells A FISH analysis of the

pVHL associates with RPS3 A schematic diagram illustrating the

pVHL inhibits protein synthesis A pVHL expression inhibits protein

Bioinformatics characterization of human pVHL Nterminus A Roman

VHL the story of a tumour suppressor gene Nature Reviews Cancer

Estrutura esquemática da pVHL com seus domínios formando um complexo ...

Estrutura esquemtica da pVHL com seus domnios formando um complexo

Sequence alignment of pVHL and dVHL the alignment was generated using

Domain mapping of the interaction between U19Eaf2 and pVHL A pVHL

Decreased nuclear accumulation of endogenous hsRPB7 by pVHL 786O

Prediction of pVHLCDKN1 interactions Proteinprotein interaction

The GFP fluorescence signal caused by overexpression of ODDGFP is

Scheme of pVHL function 24 Both and domain are involved in

Ubiquitination of a Novel Deubiquitinating Enzyme Requires Direct

Mechanisms of tumor suppression by pVHL a Model of pVHLmediated

The function of pVHL a The physiological function of pVHL Under a

Schematic overview of the main findings Download Scientific Diagram

pVHL associates with preribosomes A pVHL is cosedimented with

The role of pVHL in oxygendependant hypoxiainducible factor regulated

Analysis of the activity that promotes interaction of HIF with pVHL

Knockdown of pVHL sensitizes DNAdamageinduced apoptosis dependent on

Loss of pVHL function and inhibitory phosphorylation of GSK3 correlate

The eye defect caused by overexpression of SIMA is suppressed by

Analysis of naturally occurring pVHL point mutants PMC3101603 A

Serines 68 and 72 of pVHL are required for the regulation of pVHLs

pVHL mutants differentially regulate mitochondrial protein

Computational prediction of the pVHLbinding pocket in the RNA

hVDU1 binding to VCB complex hVDU1 FLAGpVHL19 6 HisEC and EB were

Phospholamban Is Downregulated by pVHLMediated Degradation through

pVHL does not appear to in fl uence global protein synthesis in 7860

Frontiers The Roles of VHLDependent Ubiquitination in Signaling and

Inactivation of VHL by Tumorigenic Mutations That Disrupt Dynamic

von HippelLindau protein binds hyperphosphorylated large subunit of

pVHL mutations in its alpha or beta domain decrease TSP1 levels a

PVHL regulation of mitochondrial mass is hydroxylation and EGLN3

The function of pVHL a The physiological function of pVHL Under a

hVDU1 binding to VCB complex hVDU1 FLAGpVHL19 6 HisEC and EB were

Immunodetection of endogenous pVHL isoforms in tumour tissues A

pVHL 30 S68DS72D forms an E3 ligase complex but does Download

Interaction of endogenous pVHL and collagen IV AntipVHL VHL IP or

The von HippelLindau Protein pVHL Inhibits Ribosome Biogenesis and

VHL mutations and dysregulation of pVHL and PTENcontrolled pathways

pVHL negatively regulates the cellular antiviral response A

Endogenous pVHL regulates MT stability in a primary cell line A

pVHL regulates constitutive levels of Rpb1 in RCC cells A Western

Identification of critical residues for pVHL interaction located in the

AntipVHL antibodies detect specifically pVHL af U2OS were fixed

pVHL interaction with hsRPB7 A Yeast twohybrid assay followed by a

Molecular dynamic study of the pVHL mutants The structures of

Analysis of the phenotypes of the cells expressing pVHL 172 or pVHL

pVHL reexpression regulates mitochondrial protein expression A

A Viral Phospholipase A2 Is Required for Parvovirus Infectivity

pVHL 1LQBPDB is shown in cartoon representation in the left part of

haTs preferentially bind to phosphorylated pVhL on DNa damage a

pVHL 30 S68DS72D forms an E3 ligase complex but does Download

Rescue of the lethal dVHL null Drosophila by overexpression of either

pVHL Acts as an Adaptor to Promote the Inhibitory Phosphorylation of

Physiopathology of VHL disease and potential therapeutic targets

The von HippelLindau Protein pVHL Inhibits Ribosome Biogenesis and

pVHL binds to a modi fied form of HIF A pVHL defective renal

Inactivation of VHL by Tumorigenic Mutations That Disrupt Dynamic

Knockdown of pVHL sensitizes DNAdamageinduced apoptosis dependent on

Regulation of microtubule stability by the von HippelLindau tumour

The Protective Role of pVHL in ImiquimodInduced Psoriasislike Skin

PIN1 和 CDK1 共同控制 pVHL 稳定性和抑制功能,Cell Death and Differentiation - X-MOL

PIN1 CDK1 pVHL Cell Death and Differentiation XMOL

Inactivation of VHL by Tumorigenic Mutations That Disrupt Dynamic

Phospholamban Is Downregulated by pVHLMediated Degradation through

USP9X destabilizes pVHL and promotes cell proliferation PMC

Phosphorylation of pVHL by GSK3 in vivo A B and C Lysates of COS7

Proteostasis Modulators Prolong Missense VHL Protein Activity and Halt

Frontiers The Roles of VHLDependent Ubiquitination in Signaling and

Inactivation of VHL by Tumorigenic Mutations That Disrupt Dynamic

pVHL Acts as an Adaptor to Promote the Inhibitory Phosphorylation of

Loss of pVHL is sufficient to cause HIF dysregulation in primary cells

Lack of a Functional VHL Gene Product Sensitizes Renal Cell Carcinoma

Characterization of the pVHL Interactome in Human Testis Using High

Von HippelLindau Tumor Suppressor Gene SpringerLink

pVHL interacts with MDM2 is an isoformspecific manner A Left panel

Biochemical purification and pharmacological inhibition of a mammalian

Cep164 Localization

Pvhl19 Endosome Localization

Localization in Protoplast

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