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Passage Bio Inc Our Science Role of Progranulin

PGRN interactions trafficking and proteolysis Several PGRN receptors

Lysosomal functions of progranulin and implications for treatment of

The Role of Progranulin PGRN in the Pathogenesis of Glioblastoma

Parkin Levels Decrease in Fibroblasts With Progranulin PGRN

PGRN mutations identified in FTLD patients Schematic representation of

Proposed model for PGRN inducing the fibroblast activation PGRN

Transduction with PGRN or LPGRN does not alter baseline neuronal

PSAP facilitates PGRN lysosomal targeting from the extracellular space

The Role of Progranulin PGRN in the Pathogenesis of Glioblastoma

Working model of PGRN functions presented in the NAc in FTDlike

Progranulin PGRN structure and its derivative products PGRN is

PGRN immunolabeling following ND602 A Representative Download

Subcellular localization of PGRN PGRN variants and TDP43

Possible mechanism of action of progranulin PGRN in suppressing

Full article A new GRN variant in logopenic variant primary

PGRN processing is lysosomedependent a Primary Sort Grn

Progranulin Deficiency Induces Mitochondrial Dysfunction in

Progranulin PGRN structure and its derivative products PGRN is

Deficiency in progranulin PGRN does not affect vascular inflammatory

PSAP is required for PGRN lysosomal targeting in fibroblasts A

PGRN processing in Sortilinand PSAPdeficient mice AB Western blot

PGRN content in LCLs from WT controls and heterozygous and homozygous

Reduced levels of PGRN do not affect processing and the subcellular

Schematic model of the proposed signal pathways of PGRN effect in

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Progranulin PGRN structure and its derivative products PGRN is

PGRN binds to HexA through granulins G and E a CoIP assay to test the

Summary of our findings Progranulin PGRN activates endothelial

Summary of regulation of pgrn mRNA in various cell lineages The pgrn

Frontiers Molecular mechanisms and targeted therapy of progranulin in

AAVmediated PGRN expression corrects lysosomal pathology in brains of

The Role of Progranulin PGRN in the Pathogenesis of Glioblastoma

Proposed model of the roles of PGRN in inhibition of type I IFN

Cell biology of Progranulin PGRN deficiency in microglia Download

The Role of Progranulin PGRN in the Pathogenesis of Glioblastoma

Progranulin in Musculoskeletal Inflammatory and Degenerative Disorders

CD68 is not required for PGRN lysosomal trafficking A WT and Cd68

PGRN is an endogenous antiHIV factor Microglial PGRN was knocked down

PGRN as an emerging regulator of lipid metabolism in neurodegenerative

Expression and distribution of PGRN in the NAc following NAc

Trehalose rescues PGRN deficiency in patientderived primary

Frontiers Molecular mechanisms and targeted therapy of progranulin in

PGRN distribution during muscle regeneration after CTX injection

M6PR and LRP1 mediate PGRNPSAP lysosomal trafficking A Both PSAP

PGRN interactions trafficking and proteolysis Several PGRN receptors

PGRN is induced during influenza virus infection A PGRN mRNA

PSAP is required for PGRN lysosomal targeting in fibroblasts A

Diagram summarizing the progranulin PGRN deficiencyrelated nuclear

Progranulin Maintains Blood Pressure and Vascular Tone Dependent on

Molecular Medicine Reports

CD68 binds PGRN and granulin E via the mucinprolinerich domain A

PGRN does not affect CD68 localization A WT and Grn BMDMs were

PGRN promotes cell cycle progression and cell proliferation in gastric

Schematic representation showing that PGRN protects against podocyte

PGRN Levels in iPSCDerived Microglia Related to Figure 3 Download

PGRN bridges the interaction between PSAP and sortilin and

CD68 binds PGRN and granulin E via the mucinprolinerich domain A

Deficiency in PGRN triggers high blood pressure and vascular

Schematic representation of PGRN relevance in RA SLE and IVDD

Effect of PGRNGRN on soma size and neurite outgrowth AD NFH

Frontiers Molecular mechanisms and targeted therapy of progranulin in

The protein sequence of full length PGRN and its proteolytically

AntiProgranulin Antibody AF2420 RD Systems

Progranulin PGRN treatment restores vascular function and blood

PGRN antagonized the TNFα signaling. (A) Mice were sacrificed after ...

PGRN antagonized the TNF signaling A Mice were sacrificed after

Passage Bio Inc Our Science Role of Progranulin

PGRN interactions trafficking and proteolysis Several PGRN receptors

Progranulin in Musculoskeletal Inflammatory and Degenerative Disorders

Phylogenetic tree and synteny analysis of the PGRN family A

Differences of PGRN and CDK4 protein expression between gastric cancer

PGRN regulates CDK4 through the PI3KAkt signaling pathway and promotes

PGRN does not affect CD68 localization A WT and Grn BMDMs were

PGRN in developing embryos on E65 and placentas on E145 and E175

PGRN expression in microglial cells treated with high glucose HMC3

Rescue of a lysosomal storage disorder caused by Grn loss of function

The expression level of PGRN in lung cancer tissues and lung cancer

Autophagy influences PGRNmediated anabolic catabolic proliferation

BMP levels are reduced in progranulindeficient cells or brain

PGRN expression is enhanced in SCI a b Representative Western

Autophagy influences PGRNmediated anabolic catabolic proliferation

PGRN processing promotes neuronal outgrowth and branching A Time

PGRN plays a functional role during influenza virus replication A

PGRN binds to ATG5 and ATG12 through GRN G E and F A Scheme of

Intracellular progranulin PGRN prevented cigarette smoke extract

Lysosomal functions of progranulin and implications for treatment of

PGRN regulates inflammatory responses in the periphery and central

Detecting the effect of PGRN on the interaction of E2 and ERα. A The ...

Detecting the effect of PGRN on the interaction of E2 and ER A The

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Intracellular Proteolysis of Progranulin Generates Stable Lysosomal

Changes of PGRN content in the serum of mice with pulmonary fungal

Kaplan Meier curves of OS of patients with high serum PGRN ie

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PGRN Adsorption is Reduced in LoBind Tubes A A dilution series of

PGRN promotes Treg differentiation of naive CD4 T cells in vitro and

Progranulin PGRN expression and secretion are increased in

PGRN treatment promoted the activation of mammalian target of rapamycin

Knockdown of PGRN expression in vitro reduces the cholangiocyte

PGRN deficiency increases mitochondrial mass in SHSY5Y cells A

Reduced levels of PGRN do not affect processing and the subcellular

PGRNdeficient microglia are more susceptible to lysosome abnormalities

Effect of progranulin PGRN on osteoblastic gene expressions in

REST repress PGRN promoter activity a Putative REST binding

Suppression of PGRN expression in vivo inhibits biliary outgrowth after

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Frontiers Molecular mechanisms and targeted therapy of progranulin in

The level of PGRN was significantly reduced in the kidney under

Expression of PGRN in papillary thyroid carcinoma PTC tissues and PTC

PGRN promoted phosphorylation of mTOR which depended on PI3KAkt

The effects of PGRN on proliferation apoptosis migration and invasion

Microglial PGRN deficiency increases the death of cultured neurons A

Progranulin PGRN incubation attenuates vascular contractility

Human ProgranulinPGRN Antibody AF2420 by RD Systems Part of BioTechne

Surgical trauma and implant can increase plasma and local PGRN levels

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