Pgrn Structure

Progranulin PGRN structure and its derivative products PGRN is

SORT1 ligands competitively inhibit PGRN endocytosis AC Structure

PGRN promoted corneal nerve structure and functional recovery a

Progranulin PGRN structure and its derivative products PGRN is

PGRN mutations identified in FTLD patients Schematic representation of

The protein sequence of full length PGRN and its proteolytically

Each of three TNFRbinding domains of PGRN acts independently in TNFR

PGRN interactions trafficking and proteolysis Several PGRN receptors

Proposed model for PGRN inducing the fibroblast activation PGRN

The structure of Progranulin The upper panel shows that progranulin is

Progranulin and TDP43 structure and processing a The top part of the

Schematic model of the proposed signal pathways of PGRN effect in

PGRN exerts different functions on tumor cells and macrophages in human

PGRN and its biological effects in pathogenesis of breast cancer

The protein and gene structure of a mammalian progranulin A

CD68 binds PGRN and granulin E via the mucinprolinerich domain A

DTT treatment of PGRN abolishes its binding to TNFR whereas enhances

PGRN missensemutations are impaired in secretion A schematic

Generation of PGRNdeficient mice A Mouse pgrn locus targeting

Schematic depicting the domain structure of progranulin Boxed letters

PGRN does not affect CD68 localization A WT and Grn BMDMs were

MPEP decreases SORT1 expression and increases extracellular PGRN in

Association of PGRN with obesity insulin resistance and type 2

Schematic summary of differential effects of PGRN deficiency on brain

Schematic representation showing that PGRN protects against podocyte

Phylogenetic tree and synteny analysis of the PGRN family A

Summary of regulation of pgrn mRNA in various cell lineages The pgrn

PGRN is expressed in disc tissues of both human and mice and its level

Working model of PGRN functions presented in the NAc in FTDlike

AAVmediated PGRN expression corrects lysosomal pathology in brains of

The expression level of PGRN in lung cancer tissues and lung cancer

PGRN promotes axon growth from MNs a b MNs were treated with

Proposed model of the roles of PGRN in inhibition of type I IFN

Schematic summary of differential effects of PGRN deficiency on brain

PGRN is mainly localized in neuron and activated macrophagemicroglia

PGRN Levels in iPSCDerived Microglia Related to Figure 3 Download

PGRN processing into GRNs is mediated by proper lysosome function and

PGRN processing is lysosomedependent a Primary Sort Grn

Lysosomal functions of progranulin and implications for treatment of

The Role of Progranulin PGRN in the Pathogenesis of Glioblastoma

Schematic diagram summarizing the strategies applied to inhibit

Targeting Granulin Haploinsufficiency in Frontotemporal Dementia From

Progranulin as a Potential Therapeutic Target in ImmuneMediated Disea

RCSB PDB 8T8S SortilinPGRN peptide complex

Progranulin binds to multiple cell surface receptors A Progranulin

Progranulin as a Potential Therapeutic Target in ImmuneMediated Disea

Full article A new GRN variant in logopenic variant primary

Intracellular Proteolysis of Progranulin Generates Stable Lysosomal

Progranulin PGRN Marker of Neuroinflammation

Seventy pathogenic GRN mutations have been identified in over 230

Progranulin in neurodegenerative dementia Wang 2021 Journal of

The Role of Progranulin PGRN in the Pathogenesis of Glioblastoma

Faculty Highlight Emory School of Medicine

The Role of Progranulin PGRN in the Pathogenesis of Glioblastoma

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Progranulin in wound repair and inflammation On the left of the panel

Antioxidants Free FullText Progranulin Deficiency Induces

Delivering progranulin to neuronal lysosomes protects against

Frontiers Molecular mechanisms and targeted therapy of progranulin in

Progranulin in Musculoskeletal Inflammatory and Degenerative Disorders

Discovery of SmallMolecule Inhibitors Targeting ProgranulinSortilin

Progranulin in Musculoskeletal Inflammatory and Degenerative Disorders

Frontiers Molecular mechanisms and targeted therapy of progranulin in

Some Features of PGRN microglia and Alzheimers disease A Confocal

The granulin gene family from cancer to dementia Bateman 2009

PDF Insights into the role of progranulin in immunity infection and

Frontiers Molecular mechanisms and targeted therapy of progranulin in

Progranulin Directly Binds to the CRD 2 and CRD3 of TNFR Extracellular

Hypothetical model on regulation of lysosomal lipids by progranulin

Progranulins Protective Mechanisms and Therapeutic Potential in

Frontiers Molecular mechanisms and targeted therapy of progranulin in

Microglial Progranulin Involvement in Alzheimers Disease and

Diagram summarizing the progranulin PGRN deficiencyrelated nuclear

Delivering progranulin to neuronal lysosomes protects against

Summary of our findings Progranulin PGRN activates endothelial

RCSB PDB 8T8R SortilinPGRN peptide complex

Progranulins Protective Mechanisms and Therapeutic Potential in

Cell biology of Progranulin PGRN deficiency in microglia Download

Progranulin as a Potential Therapeutic Target in ImmuneMediated Disea

Progranulin as a therapeutic target in neurodegenerative diseases

RCSB PDB 8T8R SortilinPGRN peptide complex

SORTPGRN interaction inhibitor 2 SORTPGRN Interaction Inhibitor

Genetics of frontotemporal lobar degeneration Request PDF

Progranulin Oncogenic Network in Solid Tumors

Frontiers Molecular mechanisms and targeted therapy of progranulin in

Proposed model illustrating the multiple signaling pathways by which

Delivering progranulin to neuronal lysosomes protects against

Frontiers Molecular mechanisms and targeted therapy of progranulin in

Progranulin as a therapeutic target in neurodegenerative diseases

Possible mechanism of action of progranulin PGRN in suppressing

Lysosomal functions of progranulin and implications for treatment of

Progranulin is essential for bone homeostasis and immunology Chen

Progranulins Protective Mechanisms and Therapeutic Potential in

Regulation of microglial activation by progranulin through the NF-κB ...

Regulation of microglial activation by progranulin through the NFB

A summary of the effects of progranulin in tumorigenesis The left

Increased progranulin in the skin of amyotrophic lateral sclerosis An

Delivering progranulin to neuronal lysosomes protects against

Progranulins Protective Mechanisms and Therapeutic Potential in

Deficiency in progranulin PGRN does not affect vascular inflammatory

Schematic diagram summarizing the strategies applied to inhibit

SORTPGRN interaction inhibitor 1 SortilinProgranulin Interaction

Progranulin as a therapeutic target in neurodegenerative diseases

Progranulin normal function and role in neurodegeneration Eriksen

Possible mechanism of action of progranulin PGRN in suppressing

Progranulin modulator3 TargetMol

The Genetics of Frontotemporal Dementia Neurologic Clinics

Progranulin modulator1 TargetMol

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Progranulin

Deficiency in progranulin PGRN does not affect vascular inflammatory

Structural model of PGRPS2 and PGRPS3 proteins Threedimensional

Association Between Progranulin and Gaucher Disease eBioMedicine

Parkin Levels Decrease in Fibroblasts With Progranulin PGRN

Rescue of a lysosomal storage disorder caused by Grn loss of function

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