Pfv Integrase

PFV virus integrase DNA deoxyribonucleic acid complex Computer model

Domain organization of IN and structure of PFV intasome A Integrase

PFV virus integrase DNA complex Stock Image C0355871 Science

RCSB PDB 4E7K PFV integrase Target Capture Complex TCCMn freeze

Protein expression levels of HIV1 integrase ngMinE and PFV integrase

SDSPAGE comparison of protein expression levels for PFV integrase

Recombinant PFV Integrase Purification form Nuclease Contamination

RCSB PDB 4E7J PFV integrase Target Capture Complex Apo form TCC

RCSB PDB 4E7L PFV integrase Strand Transfer Complex STCMn

Retroviral Integrase Structure and DNA Recombination Mechanism PMC

Solution Conformations of Prototype Foamy Virus Integrase and Its

Schematic depiction of the arrangement of integrase domains in the

Integrase IN functional structure and architecture The three domain

Multifaceted HIV integrase functionalities and therapeutic strategies

Architecture of the PFV intasomea Views along left and

CCD does not inhibit concerted DNA integration A Schematic of the PFV

The mode of interaction of PFV intasome and kinetochore proteins with

Architecture of PFV and related retroviral intasomes A PFV intasome

Assessment of proviral integration of the PFV vector genome a

PFV replication cycle PFV attaches to an unknown cellular receptor

PFV intasome structures A left crystallographic asymmetric unit with

Subcellular localization of prototype foamy viral integrase PFVIN

VCY mediates inhibition of PFV replication via interaction with the

Solution Conformations of Prototype Foamy Virus Integrase and Its

Subcellular localization of prototype foamy viral integrase PFVIN

CCD does not inhibit concerted DNA integration A Schematic of the PFV

The representative binding modes of PFV INDNA with four Download

PFV and HIV1 IN sequence alignments A Structurebased amino acid

Multifaceted HIV integrase functionalities and therapeutic strategies

Integrase Strand Transfer Inhibitors Are Effective AntiHIV Drugs

Full article Patterns of resistance development with integrase

Crystal structures of PFV IN in complex with INSTI A Download

The first slow motion modes of PFV IN and INDNA The front and side

Molecular mechanisms of retroviral integrase inhibition and the

Illustration of PFV integration to a linear NPS target DNA The PFV

Structure and function of retroviral integrase PMC

Strand transfer activity of recombinant PFV IN A Schematic of strand

Architecture of PFV and related retroviral intasomes A PFV intasome

RAL overlaid onto DTG in the active site of the PFV intasome The

PFV intasome structures A left crystallographic asymmetric unit with

Mechanics of PFV 3processing and strand transfer Top panel a close

PFV integration in the presence of DNA oligomers encoding the preferred

Illustration of PFV integration to a linear NPS target DNA The PFV

Assembly of PFV heterointasomes SSC A Strategy for assembly and

The PFV intasome a The extended string of domains of one monomer of

Solution Conformations of Prototype Foamy Virus Integrase and Its

PFV intasome structures A left crystallographic asymmetric unit with

Increasing salt concentration decreases PFV integration into

pfv QBPSBG

Schematic representation of the DNAbound active subunits in the PFV

PFV integration to plasmids encoding the preferred integration site

StructureGuided Optimization of HIV Integrase Strand Transfer

The fast and slow motion modes of PFV IN and INDNA systems A Fast

CryoEM reveals a novel octameric integrase structure for

Analysis of PFV Gag mutants using the oneplasmid vector system

Retroviral integrase protein and intasome nucleoprotein complex structures

Assessment of proviral integration of the PFV vector genome a

PCA does not alter the kinetics of PFV intasome integration PFV

Probing the structural dynamics of PFV intasome during target capture

Assessment of proviral integration of the PFV vector genome a

RAL overlaid onto DTG in the active site of the PFV intasome The

Realtime PFV intasome catalyzed strand transfer a Illustration of the

Model of a dimeric PFV PR A Dimers of PRRT generated in silico by a

Crystal Structures of a PFV intasome with inhibitor MB76 39

Time course of PFV integration to a nucleosome target A PFV intasomes

Cartoons of PFV IN and integration reaction products a FL PFV IN is

Interactions of Dolutegravir within the active site of PFV intasome

Sequence alignment of the Integrase IN catalytic domain among

The PFV genome Genomic organization of PFV with highlighted

Probing the structural dynamics of PFV intasome during target capture

Schematic illustration of the expression constructs and PFV Gag

Interactions of Dolutegravir within the active site of PFV intasome

PFV and HIV1 IN sequence alignments A Structurebased amino acid

Schematic illustration of PFV Env membrane topology and expressions

PFV intasome activity following preincubation PFV intasomes with Cy5

A 425nucleotide fragment from the conserved region of the integrase

IFITM3 knockdown promotes PFV replication A Levels of IFITM3 protein

Architecture of the PFV PRRT colored according to subdomains with B

PDB101 Molecule of the Month Integrase

Biochemical characterization of the PFV production levels particle

Multifunctional facets of retrovirus integrase

Downregulation of RelB by PFV infection A After PFV infection of

In vivo cell culture PRactivity assays and deletion of integrase

PFV binds to heparin Replicationincompetent PFV encoding an EGFP

Affinity of PFV IN truncation mutants for 601 nucleosomes in the

RelB downregulates the activation of PFV LTR and IP by Tas A and B

Time course of PFV integration to a nucleosome target A PFV intasomes

Integrase Strand Transfer Inhibitors Are Effective AntiHIV Drugs

Increasing salt concentration decreases PFV integration into

Infectious PFV vector particles generated by separate PFV Pol subunit

PREB upregulation after PFV infection A The result of Download

Figure 1 from Integrase residues that determine nucleotide preferences

IUCr Structural studies of the catalytic core of the primate foamy

Particle composition and structural protein organization of PFV A

IUCr Structural studies of the catalytic core of the primate foamy

Chemical structures of a RAL b EVG and c DTG and their modes of

Chemical structures of A raltegravir RAL B elvitegravir EVG

ENS Cachan Institut dAlembert Nucleoprotein complex formation

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Integration assay reaction products DNA oligomers mimicking the viral

Genome of prototype foamy virus PFV Depicted is the molecular clone

Heterointasomes STC and homointasomes STC exhibit similar

The integration process IN catalyzes the integration of the HIV DNA

Atlas Entry Persistent fetal vasculature PFV

Detection and Removal of Nuclease Contamination During Purification of

PHF11 inhibits FV infection postintegration A Schematic

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Analyses of in vitro activities processing and assembly of the viral

MolecularGenetics category videos

Schematic representation of the FV Gag Pol and Env protein

Structural Insights on Retroviral DNA Integration Learning from Foamy

The mutations in PFV1 IN do not alter its karyophilic property A

Prototype Foamy Virus Protease Activity Is Essential for Intraparticle

Frontiers Construction of a New Phage Integration Vector pFIVVal for

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Nucleotide preferences at sites of WT and IN mutant enzyme integration

Prototype Foamy Virus Protease Activity Is Essential for Intraparticle

Retroviral prototype foamy virus intasome binding to a nucleosome

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