Plk4 Domain

Plk4 phosphorylates the Nterminal domain of Asl Download Scientific

Asl contains a second Plk4 PB1PB2binding domain in its C terminus

Plk4 phosphorylates its kinase domain and AslA generating a state

RCSB PDB 8XPG The Crystal Structure of polo box domain of Plk4 from

CDK1CyclinB Binds STIL on Its CC Domain and Competes with PLK4 Binding

Plk4 phosphorylates Ana2 in an ordered pattern to regulate STAN domain

Plk4 phosphorylates the STIL SAN domain in vivo A Schematic of STIL

Proposed binding mode of compound 14i to the PLK4 kinase domain

The Structure of the Plk4 Cryptic Polo Box Reveals Two Tandem Polo

Structural dissection of Plk4ZYG1 a Schematic showing domain

Comparison of Plk4 protein structure and crystal structure with other

Recruitment of the pololike kinases Plk4ZYG1 and domain organization

Expression levels of PLK4 protein in different normal tissues and

Plk4 is degraded in a Slimbdependent manner and is stabilized by

The Structure of the Plk4 Cryptic Polo Box Reveals Two Tandem Polo

Speculative multistep model for Plk4 activation and regulation A

Model of Plk4 turnover regulation by domainspecific and cell

Regulation of Autophosphorylation Controls PLK4 SelfDestruction and

The Structure of the Plk4 Cryptic Polo Box Reveals Two Tandem Polo

Plk4 autophosphorylates a 24aa region to promote its own destruction

The Structure of the Plk4 Cryptic Polo Box Reveals Two Tandem Polo

Consequences of PLK4 mutations on the transcript and protein a

Complete rings of PLK4 are not observed in unperturbed cycling cells

A Scheme of the different Plk4 constructs used for the cotransfection

PIPKIc directly interacts with the CPB domain of PLK4 A Endogenous

Plk4 displays autoinhibition which can be relieved by L1 Download

Model for how Plk4 kinase activity autoregulates protein stability a

Ana2 binds both the putative CCDRE and PB3 domains in Plk4 A Plk4

Expression levels of PLK4 protein in different normal tissues and

Plk4 kinase activity destabilizes the protein A Schematic of mouse

Bimodal Binding of STIL to Plk4 Controls Proper Centriole Copy Number

Comparison of Plk4 protein structure and crystal structure with other

Plk4 Is a Novel Substrate of Protein Phosphatase 5

PLK4 General Information Sino Biological

Plk4 Is a Novel Substrate of Protein Phosphatase 5

PLK4 transAutoactivation Controls Centriole Biogenesis in Space

Asl stabilizes Plk4 in aggregates with supernumerary centrioles A

Plk4 autophosphorylation of L2 promotes homodimer separation AC

Plk4 kinase activity destabilizes the protein A Schematic of mouse

PLK4 transAutoactivation Controls Centriole Biogenesis in Space

CDK1CyclinB Phosphorylates STIL outside of the PLK4Interacting Domain

The structure of PLK4 and zyg1 PLK4 differs from the other members of

Regulation of Autophosphorylation Controls PLK4 SelfDestruction and

CRL4DCAF1 ubiquitin ligase regulates PLK4 protein levels to prevent

A model for how Plk4 and STIL cooperate to promote centriole assembly

Comparison of Plk4 protein structure and crystal structure with other

Assembly of Bipolar Spindle Depends on Plk4 Kinase Activity A

Frontiers PLK4 initiates crosstalk between cell cycle cell

CDK1CyclinB Phosphorylates STIL outside of the PLK4Interacting Domain

Plk4 activity enhances the interaction between Ana2 and Sas4 producing

Structural features of human Plk4 Plk4 possesses an Nterminal kinase

PLK4 localizes asymmetrically to centrioles A HeLa cells stably

The variant of PLK4 in NOA42 A The family affected by the variant in

A simple Turing reactiondiffusion model explains how PLK4 breaks

Plk4 can phosphorylate in trans to promote its degradation without

Hierarchical recruitment of Plk4 and regulation of centriole biogenesis

Drosophila Plk4 autophosphorylation promotes its own degradation A

KAT2AKAT2Btargeted acetylome reveals a role for PLK4 acetylation in

PLK4 is essential for centriole assembly in both cycling cells and

Dimer mutant Plk4 is catalytically active in cells and induces

PLK4 transAutoactivation Controls Centriole Biogenesis in Space

Full article KAT2mediated PLK4 acetylation contributes to genomic

CRL4DCAF1 ubiquitin ligase regulates PLK4 protein levels to prevent

Speculative multistep model for Plk4 activation and regulation A

Inhibition of AS Plk4 leads to centrosome loss and growth arrest A

Regulation of Autophosphorylation Controls PLK4 SelfDestruction and

A PLK4 mutation causing azoospermia in a man with Sertoli cellonly

A noncanonical function of Plk4 in centriolar satellite integrity and

Recruitment of centriolar proteins including PLK4 and duplication of

PLK4 induces cell cycle arrest at the G0G1 phase in KFs A Left

PLK4 localizes asymmetrically to centrioles A HeLa cells stably

PLK4 and MPS1 protein sequence alignment in humans and other vertebrate

PLK4 transAutoactivation Controls Centriole Biogenesis in Space

Molecular basis for unidirectional scaffold switching of human Plk4 in

Regulation of Autophosphorylation Controls PLK4 SelfDestruction and

PLK4 centriole turnover and site selection is driven by linker

Structural dissection of Plk4ZYG1 a Schematic showing domain

Plk4 modulates its solubility by autophosphorylation in vitro a

PLK4 expression was significantly increased in CRC tissues A

Cep152 and Plk4 interaction and localization A Schematic of Cep152

CRL4DCAF1 ubiquitin ligase regulates PLK4 protein levels to prevent

Bimodal centriolar distribution of Plk4 across the cell cycle a

Plk4 is required for cytokinesis and maintenance of chromosomal

PLK4 selfphosphorylation drives the selection of a single site for

Molecular Basis for Unidirectional Scaffold Switching of Human Plk4 in

Plk4 is required for cytokinesis and maintenance of chromosomal

PoloLike Kinase 4s Critical Role in Cancer Development and Strategies

Pololike kinase 4 A molecular linchpin in cancer and its management PMC

PLK4 Master Regulator of Centriole Duplication and Its Therapeutic

Polo Boxes Come out of the Crypt A New View of PLK Function and

Precise interplay of PLK4 STIL and SAS6 at the core of centriole

Pololike Kinase 4 Shapes Up Structure

Pololike kinase family

Pololike Kinase 4 A Molecular Culprit in Skin Cancer Pathogenesis PMC

Development Reproduction

Pololike Kinase 4 Autodestructs by Generating Its SlimbBinding

Pololike kinase 4 homodimerization and condensate formation regulate

Pololike Kinase 4 A Molecular Culprit in Skin Cancer Pathogenesis

Frontiers PoloLike Kinase 4s Critical Role in Cancer Development

Full article Centriole duplication

Proposed model depicting the mechanism of Ana2 recruitment to the site

Role for pololike kinase 4 in mediation of cytokinesis PNAS

Schematic diagram of human Plk1 to Plk5 Plk14 contain the kinase

Autophosphorylation of Pololike Kinase 4 and Its Role in Centriole

Full article Centriole duplication

CDK1 Prevents Unscheduled PLK4STIL Complex Assembly in Centriole

Role for pololike kinase 4 in mediation of cytokinesis PNAS

Dual Positive Feedback Drives Symmetry Breaking of PLK4STIL Complexes

Structural and functional analyses of the FAM46CPlk4 complex PMC

Full article From Plk1 to Plk5

Pololike kinase 4 homodimerization and condensate formation regulate

Role for pololike kinase 4 in mediation of cytokinesis PNAS

PLK4 Master Regulator of Centriole Duplication and Its Therapeutic

The Molecular Basis for Phosphodependent Substrate Targeting and

Liang ZHANG Associate Investigator PhD University of Science and

Promotion and Suppression of Centriole Duplication Are Catalytically

CDK1 Prevents Unscheduled PLK4STIL Complex Assembly in Centriole

Pololike kinase 4 controls centriole duplication but does not directly

PLK4 Structure Kinase Domain

PLK4 Binding by SPR

PLK4 Inhibition

Plk1 Kinase Domain

Plk1 Stucture Domains

Plk Pathway

Linker and PLK4 Binder Part in PLK4 Inhibitor

PLK4

PLK4 Centriole

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