Ossification Anatomy
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.+The+patches+of+primary+bone+are+interspersed+between+islands+of+mesenchymal+connective+tissue%3B+some+may+remain+to+become+Haversian+canals+of+forming+osteons.+The+marrow+cavity%2C+filled+with+small%2C+dark+hematopoietic+cells%2C+is+seen+at+the+bottom+of+the+image.+Osteoclasts+are+frequently+seen+at+the+marrow+side+of+the+bone.+B.+Endochondral+ossification+at+the+epiphyseal+growth+plate+in+a+human+embryonic+long+bone.+Five+zones+of+cartilage+are+labeled+from+top+to+bottom:+resting+cartilage+zone%2C+proliferating+zone%2C+hypertrophy+zone%2C+calcification+zone%2C+and+ossification+zone.+The+organized+columns+of+proliferating+and+hypertrophic+chondrocytes+produce+interstitial+expansion+that+moves+the+epiphyseal+plate+toward+the+top%2C+away+from+the+midpoint+of+the+diaphysis.+Hypertrophic+chondrocytes+are+intermixed+with+those+undergoing+calcification+(dark+blue+areas).+In+the+pink+regions%2C+the+calcified+cartilage+has+been+converted+to+bone%2C+which+is+then+pared+away+by+osteoclasts+on+the+marrow+surfaces.+C.+Long+bone+development+by+endochondral+and+intramembranous+ossification.+The+diagram+illustrates+how+a+hyaline+cartilage+model+of+a+long+bone+is+converted+into+a+growing+bone%2C+beginning+with+the+formation+of+a+collar+around+the+middle+of+the+diaphysis.+The+complete+ossification+(closure)+of+the+epiphyseal+growth+plate+o.jpg)











![Ossification process of the long bone in mammals [19] | Download ...](https://www.researchgate.net/publication/331300681/figure/fig1/AS:962697030033425@1606536266576/Ossification-process-of-the-long-bone-in-mammals-19.png)























