Opa1 Structure

The threedimensional structure of human OPA1 protein A

Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and

Opa1 KD disrupts mitochondria structure and function induces metabolic

Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and

The threedimensional structure of human OPA1 protein A

Crystal structure of OPA1MGD A Scheme showing the domains of human

OPA1 model and DOA mutations Homology model of human OPA1

CryoEM structure of sOPA1 in the presence of GDPAlFx highlighting

Prediction of OPA1 homodimeric interaction A One stable mode of

Mitochondrial Membrane DynamicsFunctional Positioning of OPA1

Molecular model of the dual function of OPA1 in mitochondrial inner

OPA1 regulation of mitochondrial dynamics in skeletal and cardiac

Mitochondrial Membrane DynamicsFunctional Positioning of OPA1

Crystal structure of OPA1MGD A Scheme showing the domains of human

Frontiers Mitochondrial OMA1 and OPA1 as Gatekeepers of Organellar

Mitochondrial Membrane DynamicsFunctional Positioning of OPA1

Schematic Representation of the Hierarchic Features Rescued by OPA1 and

The short variant of the mitochondrial dynamin OPA1 maintains

OPA1 as a Cancer Target Molecular Mechanisms Structural Insights and

PDF Opa1 helical structures give perspective to mitochondrial dysfunction

OPA1 and PARL Keep a Lid on Apoptosis Cell

Interface 7 of the OPA1 assembly is essential for the regulation of

Mitochondrial Membrane DynamicsFunctional Positioning of OPA1

OPA1 mRNA splice forms that are partially processed have substantial

PDF Opa1 helical structures give perspective to mitochondrial dysfunction

OPA1 Isoforms in the Hierarchical Organization of Mitochondrial

OPA1 promotes ferroptosis by augmenting mitochondrial ROS and

The short variant of the mitochondrial dynamin OPA1 maintains

OPA1 Isoforms in the Hierarchical Organization of Mitochondrial

Docking of SMgm1 crystal structure into cryoEM map of SOPA1 coated

The short variant of the mitochondrial dynamin OPA1 maintains

RCSB PDB 8VLZ CryoEM structure of human SOPA1 assembled on lipid

OPA1 mRNA and protein expression in spiral ganglion neurons of the rat

Opantimirs A class of antagonizing microRNAs that upregulate Opa1 and

RCSB PDB 8VM4 CryoEM structure of human SOPA1 assembled on lipid

RCSB PDB 8EFT CryoEM of the soluble OPA1 interfaces from the apo

RCSB PDB 8EFR CryoEM of the soluble OPA1 interfaces with GDPAlFx

The function of short OPA1 forms is linked to mitochondrial fission

RCSB PDB 8CT9 CryoEM structure of human SOPA1 assembled on lipid

Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1

OPA1 mRNA and protein expression in spiral ganglion neurons of the rat

PDF Opa1 helical structures give perspective to mitochondrial dysfunction

Contrasting pathophysiological mechanisms of OPA1 mutations in

The Balance of MFN2 and OPA1 in Mitochondrial Dynamics Cellular

OPA1 Controls Loading of Cholesterol in the Inner Membrane of Purified

RCSB PDB 8EFT CryoEM of the soluble OPA1 interfaces from the apo

The short variant of the mitochondrial dynamin OPA1 maintains

OPA1 diseasecausing mutants have domainspecific effects on

Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane

OPA1 Controls Loading of Cholesterol in the Inner Membrane of Purified

OPA1 regulation of mitochondrial dynamics in skeletal and cardiac

Frontiers Mitochondrial OMA1 and OPA1 as Gatekeepers of Organellar

Overall schematic for the involving of OPA1 in mitochondrial

SMYD1a regulates OPA1 expression in the cardiomyocyte A OPA1 oligomers

The Balance of MFN2 and OPA1 in Mitochondrial Dynamics Cellular

Derivation and Characterization of Isogenic OPA1 Mutant and Control

The function of short OPA1 forms is linked to mitochondrial fission

A recurrent deletion mutation in OPA1 causes autosomal dominant optic

Lack of Opa1 alters mitochondrial morphology and cristae structure a

OPA1 diseasecausing mutants have domainspecific effects on

Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane

Opa1 protein level and mitochondrial morphology in MEFs isolated from

A combination of long and short OPA1 isoforms increases mitochondrial

OPA1 processing is dispensable for mitochondrial fusion A and B

Opa1 oligomer and mitochondrial cristae integrity A B BNPAGE of

Two peptidases regulate OPA1 cleavage at S1 Newly imported OPA1

Loss of OPA1 triggers apoptosis a kinetic of appearance of the

OPA1 helical structures give perspective to mitochondrial dysfunction

Loss of OPA1 induces fragmentation of the mitochondrial network HeLa

OPA1 diseasecausing mutants have domainspecific effects on

OPA1 influences the inner membrane morphology Knockdown KD of OPA1

Derivation and Characterization of Isogenic OPA1 Mutant and Control

Differential expression of OPA1 mRNA and OPA1 isoforms A Schema of

Epithelial OPA1 links mitochondrial fusion to inflammatory bowel

The Balance of MFN2 and OPA1 in Mitochondrial Dynamics Cellular

Frontiers Optimized OPA1 Isoforms 1 and 7 Provide Therapeutic Benefit

OPA1 Controls Apoptotic Cristae Remodeling Independently from

Knockdown of OPA1 disrupts cristae structure A Representative TEM

Mitochondrial dysfunction induces OPA1 processing by OMA1 A OMA1

Model of the human SOPA1 bound to membranes Lipidbinding triggers the

Mitochondrial Fusion The Machineries In and Out Trends in Cell Biology

Mitochondrial Function OMA1 and OPA1 the Grandmasters of

Structural organization of OPA1MGD monomer and dimer A The

Model of the human SOPA1 bound to membranes Lipidbinding triggers the

Mitochondrial Dynamics in Neurodegenerative Diseases Unraveling the

About Our Research Structural Cell Biology Section NIDDK

In situ architecture of Opa1dependent mitochondrial cristae remodeling

OPA1 a molecular regulator of dilated cardiomyopathy Chen 2023

Model of IMM fusion by sOPA1 Left mitochondria in the early stages of

Summarizing model Schematic representation showing the different steps

Proposed mechanism of OPA1mediated mitochondrial IM fusion Human

Structural mechanism of mitochondrial membrane remodelling by human

Posttranslational modifications of mitochondrial fission and fusion

Comparison of sOPA1 dimers and assembly in apo and GDPAlFxbound

Frontiers Repeated Aconitine Treatment Induced the Remodeling of

The Role of Swelling in the Regulation of OPA1Mediated Mitochondrial

Mitochondrial fusion and fission in mammalian cells A Openi

Prohibitin 1 tethers lipid membranes and regulates OPA1mediated

Mitochondrial Dynamics and Metabolic Regulation Trends in

OMA1Mediated Mitochondrial Dynamics Balance Organellar Homeostasis

Proteolytic Regulation of Mitochondrial Dynamics PMC

Localization of OMA1 to mitochondria in human cells A HeLa cells

Developmental and Tumor Angiogenesis Requires the MitochondriaShaping

Model of the human SOPA1 bound to membranes Lipidbinding triggers the

Autosomal dominant optic atrophy PPTX

OPA1mediated mitochondrial cristae remodeling Diagram illustrating

Optic Atrophy 1 Protein Function at Norris Ferguson blog

Pathways for proteolytic processing of OPA1 A The co Openi

Targeting OPA1Mediated Mitochondrial Fusion Contributed to Celastrols

Interfaces involved in sOPA1 helical assembly af Interfaces between

Mitochondria are extensively fragmented in the cells depleted of both

The Opa1Dependent Mitochondrial Cristae Remodeling Pathway Controls

OPA1mediated mitochondrial cristae remodeling Diagram illustrating

Expression of LOPA1 restores mitochondrial morphology in Phb2

The Opa1Dependent Mitochondrial Cristae Remodeling Pathway Controls

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