Nphp Module Cilia

HYLS1 depletion interrupts the assembly of NPHP module at transition

IFT trains overcome an NPHP module barrier at the transition zone PMC

NPHP knockdown cells have abnormal cilia in 2D cultures A

Figure 1 from MKS and NPHP modules cooperate to establish basal body

NPHP proteins function at the ciliary gate transition zone A

MKSMKSR and NPHP proteins form part of a functional interaction

A Longitudinal section of a diseased NPHP kidney compared with a

MKSMKSR and NPHP proteins are organized hierarchically as modules and

MKSNPHP module proteins control ciliary shedding at the transition

MKS and NPHP modules cooperate to establish basal bodytransition zone

Nephrocystindeficient respiratory epithelial cells form normal cilia

Subcellular localization of the NPHP molecules nephrocystins

Cilia Function

MKS and NPHP modules cooperate to establish basal bodytransition zone

The Inv compartment of renal cilia is an intraciliary signalactivating

PKD2GFP localizes to abnormally formed CEM cilia in nphp1 and nphp4

MKSNPHP module proteins control ciliary shedding at the transition

PKD2GFP localizes to abnormally formed CEM cilia in nphp1 and nphp4

NPHP5 interaction with Cep290 is crucial for cilia formation A

RNAimediated suppression of NPHP5 inhibits an early step of cilia

Figure 3 from MKS and NPHP modules cooperate to establish basal body

The Inv compartment of renal cilia is an intraciliary signalactivating

MKS and NPHP modules cooperate to establish basal bodytransition zone

LifeSaver or Undertaker The Relationship between Primary Cilia and

MKSNPHP module proteins control ciliary shedding at the transition

NPHP proteins are binding partners of nucleoporins at the base of the

MKSNPHP module proteins control ciliary shedding at the transition

Effect of NPHP3 on Tβ4expression and primary cilia formation. (a-d ...

Effect of NPHP3 on T4expression and primary cilia formation ad

C elegans NPHP genes synthetically interact with bbs5 to affect

A Longitudinal section of a diseased NPHP kidney compared with a

A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles

NephronophthisisPathobiology and Molecular Pathogenesis of a Rare

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Xenopus Nphp4 is essential for building functional cilia A and B

Protein Interaction Analysis Provides a Map of the Spatial and Temporal

Summary of NPHPNUP interactions Components of the inner ring

Mapping the NPHPJBTSMKS Protein Network Reveals Ciliopathy Disease

In vitro modeling and rescue of ciliopathy associated with IQCB1NPHP5

nphp1 and nphp4 mutants have misshaped long and stunted cilia A

Localization of fulllength and truncated NPHP4 in multiciliated cells

nphp2 is the ortholog of mammalian INVS is expressed in ciliated

Figure 1 from Functional characterization of the C elegans

The nphp2 and arl13 Genetic Modules Interact to Regulate Ciliogenesis

MKS6 and NPHP4 are collectively required for BBTZ attachments to

Model of the composition of the proximal cilium ARL13 is depicted as

NPHP4 controls the subcellular localization of NPHP1 in human ciliated

The EF hand is necessary for proper NPHP2 localization and function

The JoubertMeckelNephronophthisis Spectrum of Ciliopathies

Functional interactions between TZ proteins are required for correct

SIM of two ciliary localization patterns of NPHP3 A SIM IF of NPHP3

Caenorhabditis elegans homologs of ciliopathy proteins localize to

MKSNPHP proteins are required for ciliary gate function but not for

Repurposing small molecules for nephronophthisis and related renal

The nphp2 and arl13 Genetic Modules Interact to Regulate Ciliogenesis

The transition zone A Freezeetch electron micrograph of tracheal

Phosphorylation at the Helm KinaseMediated Regulation of Primary

FMD

nphp2 mutants are moderately dye filling defective and have defects in

nphp2 is the ortholog of mammalian INVS is expressed in ciliated

Frontiers Publishing Partnerships Molecular Diagnostics of

Mapping the NPHPJBTSMKS Protein Network Reveals Ciliopathy Disease

NPHP2GFP ARL13GFP and GFPUNC119 colabel with GT335 staining

MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition

Mapping the NPHPJBTSMKS Protein Network Reveals Ciliopathy Disease

Inturned plays a role similar to Nphp4 for normal ciliogenesis and

Cilium structure analysis of nph1nph4 double mutants A Cilium

Cilium length structure and motility in nphp4 morphants AD View of

The nphp2 and arl13 Genetic Modules Interact to Regulate Ciliogenesis

Genetic kidney diseases Caenorhabditis elegans as model system

Schematic of nuclear and ciliary gating complexes A At the nuclear

PDF The nphp2 and arl13 Genetic Modules Interact to Regulate

A schematic diagram summarizing relative locations of inversin NPHP2

CEM CEP and OLQ ciliary ultrastructure is abnormal in nphp4 mutants

Schematic representation of some proteins localized in the ciliumbasal

PDF A threestep process of Nphp3 ciliary localization

Plk1 colocalizes with NPHP1 at the base of the cilium A Ciliated

Consequence of NPHP4 missense mutations on NPHP4 localization and the

PDF CILIA before and after

The genetic landscape and clinical spectrum of nephronophthisis and

Mapping the NPHPJBTSMKS Protein Network Reveals Ciliopathy Disease

The nphp2 and arl13 Genetic Modules Interact to Regulate Ciliogenesis

Evolutionarily conserved association of TMEM107 with the TZlocalized

ARL13B regulates juxtaposed ciliacilia elongation in BBSome dependent

The nphp2 and arl13 Genetic Modules Interact to Regulate Ciliogenesis

A Phosphoinositide Code for Primary Cilia Developmental Cell

Zebrafish as a model organism to study the function of TMEM218 AC

CSPP Is a Ciliary Protein Interacting with Nephrocystin 8 and Required

In vitro modeling and rescue of ciliopathy associated with IQCB1NPHP5

Nephronophthisis Disease Mechanisms of a Ciliopathy PMC

Full article From the cytoplasm into the cilium Bon voyage

Nephronophthisis Disease Mechanisms of a Ciliopathy PMC

Mapping the NPHPJBTSMKS Protein Network Reveals Ciliopathy Disease

PDF NPHP4 a ciliaassociated protein negatively regulates the Hippo

nphp1 and nphp4 mutants have misshaped long and stunted cilia A

Primary cilium formation was enhanced by reactive oxygen species ROS

PDF Zebrafish as a Model for Human Ciliopathies

In vitro modeling and rescue of ciliopathy associated with IQCB1NPHP5

PDF NephronophthisisAssociated Ciliopathies

Inturned plays a role similar to Nphp4 for normal ciliogenesis and

NPHP5 localizes to the distal region of centrioles and is cell cycle

Nephronophthisis Wikipedia

Nphp4 is essential for the organization of the subapical actin layer

Nonaggregating Highresolution Secondary Antibody Fluorophore

Depletion of NPHP5 or Cep290 impairs ciliary localization of a subset

Ciliary intrinsic mechanisms regulate dynamic ciliary extracellular

OSM6GFP overexpression in nphp4 mutants results in a severe SynDyf

HST31 HS 3O sulfotransferase prevents ectopic accumulation of

Formation of the transition zone by Mks5Rpgrip1L establishes a ciliary

Nphp Module

NPHP1 Cilia

Nphp5 Cilium

Transistion Zone Nphp

Cilia Transtion Zone

MKS Module Cilia Transition Zone Protein

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