Lrrk2 Rab8a

Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2

The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary

Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2

LRRK2 and RAB8a are localized to vesicular structures after chloroquine

Model for the Control of Rab8a Functions by LRRK2 Download Scientific

Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2

Rab8A and Rab10 bind to the LRRK2 Armadillo domain AC Microscale

Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to

LRRK2 and Rab8a are recruited to the membrane of damaged lysosomes A

LRRK2 mediated Rab8a phosphorylation promotes lipid storage Abstract

Pathogenic mutations of LRRK2 sequester endogenous Rab8a to lysosomes

The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary

Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2

The LRRK2 kinase substrates Rab8a and Rab10 contribute complementary

The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary

Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2

Frontiers The Emerging Functions of LRRK2 and Rab GTPases in the

A model of the recruitment of Rab8a to lysosomes and dysregulation of

Frontiers The Emerging Functions of LRRK2 and Rab GTPases in the

LRRK2 and its substrate Rab GTPases are sequentially targeted onto

LRRK2 phosphorylation status and kinase activity regulate macro

LRRK2 Is Recruited to Phagosomes and Corecruits RAB8 and RAB10 in

More LRRK2 downstream biology unravelled in major Alessi Pfeffer Mann

LRRK2 Is Recruited to Phagosomes and Corecruits RAB8 and RAB10 in

LRRK2 and idiopathic Parkinsons disease Trends in Neurosciences

The APP intracellular domain promotes LRRK2 expression to enable feed

A new LRRK2 variant in a family with Parkinsons disease affects

Rab8a phosphorylation retains interaction with MICALL1 that is

A pathway for Parkinsons Disease LRRK2 kinase to block primary cilia

Pathogenic LRRK2 compromises the subcellular distribution of lysosomes

LRRK2 G2019S promotes astrocytic inflammation induced by oligomeric

A new LRRK2 variant in a family with Parkinsons disease affects

SHSY5Y 4xSA LRRK2 cells have increased LRRK2 kinase activity towards

Membrane association enhances Rab29 activation of pathogenic LRRK2 and

The versatile functions of LRRK2 in immune cells A LRRK2 G2019S

A pathway for Parkinsons Disease LRRK2 kinase to block primary cilia

Volcano plot showing the effect of LRRK2 on interactions with HAtagged

Membrane association enhances Rab29 activation of pathogenic LRRK2 and

Rab8a phosphorylation promotes lipid droplets enlargement 3 T3L1

LRRK2 and Parkinsons disease from genetics to targeted therapy

LRRK2 and its substrate Rab GTPases are sequentially targeted onto

LRRK2 phosphorylation of Rab GTPases in Parkinsons disease Pfeffer

Home LRRK2 Resource

Pathogenic LRRK2 regulates centrosome cohesion via Rab10RILPL1

LRRK2 Is Recruited to Phagosomes and Corecruits RAB8 and RAB10 in

The LRRK2 activation cycle In the cytosol LRRK2 is monomeric and

Role of LRRK2 in physiological activities diseases and therapy

LRRK2 recruitment activity and function in organelles BonetPonce

LRRK2 recruitment activity and function in organelles PMC

Diagram for the LRRK2 functions during mouse oocyte maturation The

LRRK2 G2019S mutation enhances Rab4positive organelles dimension via

Ten endogenous Rabs are phosphorylated by LRRK2 in cells A Phostag

Dissecting the effects of GTPase and kinase domain mutations on LRRK2

The Multifaceted Role of LRRK2 in Parkinsons Disease

LRRK2 pathogenic variants increase phosphorylation of Rab GTPases A

Pathogenic LRRK2 compromises the subcellular distribution of lysosomes

Coexpression of RAB7L1 and wildtype LRRK2 causes kinasedependent

Dissecting the effects of GTPase and kinase domain mutations on LRRK2

LRRK2 negatively regulates glucose tolerance via regulation of membrane

LRRK2 Is Recruited to Phagosomes and Corecruits RAB8 and RAB10 in

SHSY5Y 4xSA LRRK2 cells have increased LRRK2 kinase activity towards

LRRK2 RAB substrates are implicated in the regulation of vesicular

The Multifaceted Role of LRRK2 in Parkinsons Disease

A feedforward pathway drives LRRK2 kinase membrane recruitment and

Unraveling LRRK2 Pathogenesis Common Pathways for Complex Genes PMC

LRRK2 and idiopathic Parkinsons disease Trends in Neurosciences

The role of microglial LRRK2 kinase in manganeseinduced inflammatory

Rationale for LRRK2 inhibition in sporadic Parkinsons disease and the

Cellular processes associated with LRRK2 function and dysfunction

Structureguided mutations in the Nterminus of LRRK2 stimulate

LRRK2 to the rescue of damaged endomembranes The EMBO Journal

LRRK2 and its substrate Rab GTPases are sequentially targeted onto

Rab8a phosphorylation promotes lipid droplets enlargement 3 T3L1

LRRK2 phosphorylation status and kinase activity regulate macro

LRRK2 Is Recruited to Phagosomes and Corecruits RAB8 and RAB10 in

LRRK2 Signalling Pathways in Parkinsons Disease Iris Publishers

LRRK2 phosphorylates Rab10 on LRRK2 endosomes A Representative

Pathogenic LRRK2 causes kinasedependent pericentrosomalcentrosomal

Fig S13 Schematic diagram of the regulatory role of LRRK2 in the

The Multifaceted Role of LRRK2 in Parkinsons Disease

LRRK2 in Parkinsons disease upstream regulation and therapeutic

LRRK2 diseaseassociated mutants with high LRRK2 endosome formation

Clinical and functional evidence for the pathogenicity of the LRRK2 p

Catalytic activities of LRRK2 phosphorylation mutants The kinase

LRRK2 and idiopathic Parkinsons disease Trends in Neurosciences

A feedforward pathway drives LRRK2 kinase membrane recruitment and

Schematic representation of LRRK2 gene and LRRK2 protein with its

A summary of consequences of LRRK2mediated Rab phosphorylations Two

Endogenous Rab38 regulates LRRK2s membrane recruitment and substrate

Advances in elucidating the function of leucinerich repeat protein

Phosphorylation of Rab GTPases by LRRK2 a Representative phosphoimages

A summary of consequences of LRRK2mediated Rab phosphorylations Two

Schematic representation of the domain structure of LRRK2 including

An Update on the Interplay between LRRK2 Rab GTPases and Parkinsons

Structural biology of Parkinsons diseaseassociated leucinerich

Conformation and dynamics of the kinase domain drive subcellular

The Lords of LRRK The Science of Parkinsons

Frontiers LRRK2Related Parkinsons Disease Due to Altered

Expression of prenylationcompetent RAB8A or of RAB8B or RAB10 with

The role of Rab GTPases in the pathobiology of Parkinson disease PMC

X Caps the Phosphate for PhosphoRab GTPase Recognition in Ciliogenesis

Figures and data in Systematic proteomic analysis of LRRK2mediated Rab

Lysosomal stress drives the release of pathogenic α-synuclein from ...

Lysosomal stress drives the release of pathogenic synuclein from

Phosphorylationspecific protein binding to Rabs A AEMS of HARab8A

The G2019S variant of leucinerich repeat kinase 2 LRRK2 alters

LRRK2RAB mediated alphasynuclein propagation Secretion of

Proposed biological roles of Rab phosphorylation by LRRK2 A Proposed

Stabilization and inhibition of LRRK2s kinase by typeI and typeII

Physiological and pathological functions of LRRK2 implications from

Development of Inducible Leucinerich Repeat Kinase 2 LRRK2 Cell

Is Glial Dysfunction the Key Pathogenesis of LRRK2Linked Parkinsons

Frontiers The function of Golgi apparatus in LRRK2associated

RAB12LRRK2 complex suppresses primary ciliogenesis and regulates

Proposed biological roles of Rab phosphorylation by LRRK2 A Proposed

Rab29dependent asymmetrical activation of leucinerich repeat kinase 2

Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2Mediated

Systematic proteomic analysis of LRRK2mediated Rab GTPase

Lysosomal stress drives the release of pathogenic synuclein from

Rab29dependent asymmetrical activation of leucinerich repeat kinase 2

Rab10 Localization Lysosome

LRRK2 Vesicle Pathway

LRRK2 Rab8a Kinase Activity Invitro

LRRK2 G2019S

Rab8

Rab3b Cancer

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