Inward/outward Occlude

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Insights into the Transport Cycle of LAT1 and Interaction with the

Conformational change between inwardopen and outwardoccluded state a

Structures of STP10 in the outward occluded conformation and the

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Comparison of XylE in the outwardfacing partially occluded and the

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Binding site prediction through SiteMap The subregions of LAT1 in the

Conformational change between inwardopen and outwardoccluded state a

A The binding site of LAT1 in the outwardoccluded conformation red

Illustration of the forward transport cycle of LeuT with known

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CryoEM reconstructions of outwardopen occluded and inwardopen

Inwardtooutward return transition of the NSS family In the

The alternatingaccess model proposed for the transporter function

Electron density for the STP10 outward occluded structure and the STP10

CFTR maps A Fitting of the inwardfacing purple 5uak and

The asymmetrical movement of TM1 and TM6 a Comparison between the

Electron density for the STP10 outward occluded structure and the STP10

Homology structure of xCT in A inward facing occluded state

Conformational transition between the outwardfacing occludedclosed

Occurrence of outwardfacing occludedclosed OFc state along the

TM1 and TM6 structural rearrangements upon substrate occlusion

A Putative gate residues are depicted in the outwardoccluded model

Schematic representation of a structurebased transport mechanism for

Homology model of the human SGLT2 based on the inward facing occluded

The intracellular gate in the two STP10 structures a View of the STP10

Structural changes from the occluded conformation to the inwardopen

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Structural changes from the outwardopen to the occluded conformation a

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Outwardand inwardfacing cavities A Slice through the surface of the

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The extracellular gate TM7b forms the occluded state and is coupled to

Conformational changes between inwardopen OCT1 and outwardopen

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Homology model of xCT inward facing occluded conformation A

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Proposed transport cycle of the DinF subfamily transporters A The

The extracellular substrategating helix TM7b a Cartoon representation

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Schematic representation of the structural models of Fpn in the

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Structures of STP10 with bound glucose and uptake a Structural changes

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Structure of the outward occluded conformation of McjD A The McjD

Interactions stabilizing the outwardfacing open state of HsPepT1 and

The occluded structure with bound ATP a The occluded structure with

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Structural comparison of the occluded and inwardopen states a

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CryoEM structures of the ABC transporter TmrAB under turnover

Transport cycle reaction coordinate and architecture of the bacterial

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Conformational changes during LPC flipping A Movement of the

The alternating access mechanism in ABC transporters deciphered by

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Differences between outwardopen left and outwardoccluded right

Structure of the outward occluded conformation of McjD A The McjD

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Neurotransmitter Transporters Structure Meets Function Structure

Clusters of histidine in the conformations of LAT1 In the outward open

A The binding site of LAT1 in the outwardoccluded conformation red

Coordination sphere changes across the Mn 2 transport cycle of

Definition of the inward and outward torque exertion directions and

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Molecular dynamics simulations sample an inward facing occluded state

Inwardfacing conformation of OATP1B1 in complex with E3S a Three

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Simple transport scheme for VcINDY In the outwardfacing state VcINDY

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Driving forcedependent block in the inward rectifier K channel

Comparison of GLUT1 in the inwardopen conformation and GLUT3 in the

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MDTOMO analysis of a synthetic dataset of TmrAB a Structure of TmrAB

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Proposed mechanism of haloacidH Symport A Transport cycle of

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An occluding object and its occluding face red creates an occluded

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Structures of MRP4 in multiple conformations along the substrate

Intracellular lateral gate in distinct conformations ac Conformational

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Proposed mechanism of Pi transport of AtPHT11 A working scheme is

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