Idh1 R132

The IDH1 R132 mutant is shown as an example to illustrate how a

The Idh1 R132 mutant protein profoundly alters the microenvironment

Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis

IDH1 R132 Mutations Desensitize MEFs to TNFaInduced Necroptosis A

IDH1 R132 mutation status was analysed using gene sequencing A PCR

IDH1 R132 mutants bind IDH1WT but IDH2 R172 mutants poorly bind

IDH1 R132 mutation status was analysed using gene sequencing A PCR

Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis

PDF Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis

IDH1 R132 Mutations Desensitize MEFs to TNFaInduced Necroptosis A

Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis

The Common Feature of LeukemiaAssociated IDH1 and IDH2 Mutations Is a

Site of mutation in IDH1 gene is R132 and in IDH2 gene is R172

Model of the effects of IDH1 R132H mutations on the murine

Generating endogenous and heterozygous IDH1 R132H mutation IDH1

The R132H mutation dominantly inhibits IDH1 activity and reduces

Genomic structure of IDH1 and IDH2 and structural model of the location

Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain

Detection of mutant IDH1 at amino acid R132H in brain tumor samples by

Mutant IDH1 Promotes Glioma Formation In Vivo Cell Reports

IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and

IDH1 R132H mutation is a rare event in myeloproliferative neoplasms as

What Is Idh1 And Idh2 Mutation JWEZ

MetaMapp visualizing metabolomics networks Effect of IDH1 mutations

Testing and IDH1 Mutations Deeper Than MDS

IDH1 and IDH2 Not Your Typical Oncogenes Cancer Cell

Active site remodeling in tumorrelevant IDH1 mutants drives distinct

Model of the effects of IDH1 R132H mutations on the murine

PDF GliomaDerived Mutations in IDH1 Dominantly Inhibit IDH1

IDH1 R132H enzymatic inhibition of 10 identified small molecule

IDH1 R132H Reference Standard 50

Temporal detection of IDH1 R132H in Sibling A at post mortem A

IDH1 R132H Mutation Enhances Cell Migration by Activating AKTmTOR

IDH1 mutation diminishes aggressive phenotype in glioma stem cells

Implications of Concurrent IDH1 and IDH2 Mutations on Survival in

Molecular mechanisms of offon switch of activities of human IDH1 by

Mutant IDH1 Differently Affects Redox State and Metabolism in Glial

Representative sequence alterations of the IDH1 gene as shown on

IDH1 R132H predicts sensitivity to BclxL inhibitionmediated

Mutant IDH1 cooperates with NPM1c or FLT3ITD to drive distinct myeloid

Heterozygous IDH1 R132H induces epigenetic and metabolic reprogramming

Oncometabolic mutation IDH1 R132H confers a metforminhypersensitive

Pathology Outlines IDH1 R132H

Detection of mutant IDH1 at amino acid R132H in brain tumor samples by

Gaining Insight into the Catalytic Mechanism of the R132H IDH1 Mutant

Evidence for Sequenced Molecular Evolution of IDH1 Mutant Glioblastoma

Identification of an IDH1 pR132L mutation in tumor tissue from a

Site of mutation in IDH1 gene is R132 and in IDH2 gene is R172

Representative sequence alterations of the IDH1 gene as shown on

Frontiers Recent advances of IDH1 mutant inhibitor in cancer therapy

Mutant IDH1 cooperates with NPM1c or FLT3ITD to drive distinct myeloid

Sequencing result of IDH1 in two different patients AC Patient with

A Tale of Two Subunits How the Neomorphic R132H IDH1 Mutation Enhances

DNA sequencing of the IDH1 gene The IDH1 R132H mutation was detected

IDH1 Mutations Disrupt Blood Brain and Barriers Cancer Cell

IDH1 pR132 mutations may not be actively involved in the

Expression of wildtype or mutant IDH1 isoforms in stable Download

A Tumor was negative for IDH1 R132 and B IDH2 R172 mutations

Structural modeling of IDH1 mutations identified in tumors A the

Molecular mechanisms of offon switch of activities of human IDH1 by

Increased mitochondrial fragmentation in IDH1 R132H A Staining with

Active site remodeling in tumorrelevant IDH1 mutants drives distinct

IDH1 and IDH2 hotspot mutation distribution separated by site of

Representative images of SRH microscopy and hematoxylin eosin IDH1

A Construction of plasmids and transfection An R132H mutation in IDH1

IDH1 R132H is intrinsically tumorsuppressive but functionally

Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and

GliomaDerived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic

IDH1 and IDH2 hotspot mutation distribution separated by site of

Metabolism and therapeutic response in acute myeloid leukemia with IDH1

D2hydroxyglutarate produced by mutant IDH1 perturbs collagen

A Rb protein in IDH1 R132H U87 cells Cells were lysed 24 h after

A distinct gene expression profile from 3Dcultured IDH1 R132H

Oncometabolic mutation IDH1 R132H confers a metforminhypersensitive

Full article The Roles of IDH1 in Tumor Metabolism and Immunity

New Clinical Trial Targets Mutations Commonly Found in Lower Grade

PPT Structure of IDH1R132H PDB 3MAR adapted from Yang B et al

Oncology Letters

PPT Structure of IDH1R132H PDB 3MAR adapted from Yang B et al

IDH1R132H

Noncanonical NonR132H IDHMutated Gliomas IntechOpen

Establishment of IDH1wild type WT IDH1mutant R132H IDH2WT

Mutant IDH is sufficient to initiate enchondromatosis in mice PNAS

NatureIDH12HG

IDH1R132 mutations correlate with copy number alterations and

IDH1IDH2

Molecular mechanisms mediating relapse following ivosidenib monotherapy

Glioblastomas GBMs with mutations in isocitrate dehydrogenase 1

IDH12 gene hotspot mutations in central nervous system tumours

IDH1R132H mutation sensitizes to ATRAinduced differentiation of

Biochemistry Vol 63 No 20 ACS Publications

PPT Structure of IDH1R132H PDB 3MAR adapted from Yang B et al

Full article IDH mutations in liver cell plasticity and biliary cancer

Establishment of IDH1wild type WT IDH1mutant R132H IDH2WT

IDH1R132H mutation causes a less aggressive phenotype and

The prognostic IDH1R132 mutation is associated with reduced NADP

PPT Structure of IDH1R132H PDB 3MAR adapted from Yang B et al

精准靶向，重塑未来：Vorasidenib在IDH突变型胶质瘤治疗中的突破与展望 - 脑医汇

VorasidenibIDH

ENGINEERING Duke iGEM 2022

Mutant IDH regulates glycogen metabolism from early cartilage

De novo pyrimidine synthesis is a targetable vulnerability in IDH

Figures

FAM110C was highly expressed in wildtype GBM cell linesA IDH1R132H

IDH1R132H mutation increases murine haematopoietic progenitors and

Analysis of IDH1R132 mutation BRAF V600 mutation and KIAA1549BRAF

Oncology Letters

The Leukemic Isocitrate Dehydrogenase IDH 12 Mutations Impair

IDH1R132H mutation sensitizes to ATRAinduced differentiation of AML

Frontiers IDH1 Linking Metabolism and Epigenetics

易基因： Nature子刊：RRBS等揭示IDH1-R132H突变通过DNA甲基化加剧顺铂诱导肾毒性｜项目文章_idh1 r132h 83.5 ...

NatureRRBSIDH1R132HDNAidh1 r132h 835

IDH1R132 mutation identified in one human melanoma metastasis but

Brain tumor vaccine links mutation targeting to eightyear survival gains

NatureIDH12HG

a HOG cells were transfected with an empty vector V IDH1WT the

Molecular structure of IDH1R132H A Initial molecular structure B

Glioblastoma IDH Wild-Type

Isocitrate Dehydrogenase Mechanism

IDH1 R132H Qtpcr

IDH1 Immunohistochemistry

IDH1 and IDH2 Mutations in Gliomas

IDH R132l R132c

Dianova IDH1 Antibody

IDH1 Cytosol

IDH1 Reaction

IDH1 Structure

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