Flcn Ragc

Structural basis for FLCN RagC GAP activation in MiTTFE substrate

Structure of FLCN in complex with FNIP2 RagA and RagC PDB ID 6ULG

Structural basis for FLCN RagC GAP activation in MiTTFE substrate

Structure of FLCN in complex with FNIP2 RagA and RagC PDB ID 6ULG

Structural basis for FLCN RagC GAP activation in MiTTFE substrate

PDF Structural basis for FLCN RagC GAP activation in MiTTFE

PDF Structural basis for FLCN RagC GAP activation in TFEB substrate

PDF Structural basis for FLCN RagC GAP activation in MiTTFE

Regulation of RagC activity and lysosomal localization of mTORC1 by

Role of FLCN Phosphorylation in InsulinMediated mTORC1 Activation and

A LeuRSFlcn complex senses LeuHcy and binds conditionally to RagC to

FLCN Arg 164 mediates GAP activity and is in a GAPincompetent position

Phosphoproteomic Analysis of FLCN Inactivation Highlights Differential

FLCN selectively interacts with inactive Rag GTPases A Download

Schematic overview of differential phosphorylation pathways upon FLCN

Rag GTPase cycling is independent of the RagCD GAP FLCN a

Frontiers A pathogenic variant in the FLCN gene presenting with pure

RagAGDP determines FLCN recruitment to lysosomes A Representative

RagC phosphorylation autoregulates mTOR complex 1The EMBO Journal XMOL

CryoEM structure of the active FLCN complex A Domain organization

The LFC stabilizes GDPbound RagA and is necessary for lysosomal FLCN

Schematic diagram of FLCN and FNIP domains and their interacting

PDF Role of FLCN Phosphorylation in InsulinMediated mTORC1

FLCN selectively interacts with inactive RagA A Representative

CryoEM structure of the active FLCN complex A Domain organization

Flcn Depletion CellAutonomously Stimulates Glycogenesis Pathways in

Regulation of RagC activity and lysosomal localization of mTORC1 by

SLC38A9NT triggers FLCN GAP activity and disassembles the LFC a SEC

Role of FLCN Phosphorylation in InsulinMediated mTORC1 Activation and

Flcn Depletion CellAutonomously Stimulates Glycogenesis Pathways in

FLCN peptide inhibits LDHA and induces apoptosis in cancer cells a

Role of FLCN phosphorylation in insulinmediated mTORC1 activation A

FLCN regulates AMPK activation and downstream Warburg metabolic

Human FLCN is predominantly localized in the nucleolus Download

The FLCN pathway A FLCN is the gene for the BirtHoggDub BHD

Phosphoproteomic Analysis of FLCN Inactivation Highlights Differential

Role of FLCN Phosphorylation in InsulinMediated mTORC1 Activation and

Loss of FLCN induces the deregulation of RhoA signalling A Three

Phosphoproteomic Analysis of FLCN Inactivation Highlights Differential

FLCN knockdown disrupts cell polarization in a threedimensional

A and B Immunohistochemical FLCN protein expression A Highgrade

PPT Figure 4 The putative FLCN pathway PowerPoint Presentation free

FLCN regulates transferrin receptor 1 transport and iron homeostasis

Figure17 Proposed hypothesis of FLCN gene function in autoimmunity

Germline and SomaticInactivating FLCN Variants in Parathyroid Cancer

Schematic overview of differential phosphorylation pathways upon FLCN

FLCN controls TFEBdependent regulation of lysosomes A Spinning disk

FLCN primarily localizes to the cytoplasm and does not regulate

Stability localization and function of FLCN variants Download

Schematic diagram shows tissuespecific effect of FLCN depletion on

FLCN regulates transferrin receptor 1 transport and iron homeostasis

A LeuRSFlcn complex senses LeuHcy and binds conditionally to RagC to

Characterizing the tumor suppressor activity of FLCN in BirtHoggDub

Knockdown of FLCN shRNA 3 in 786O A or RCC4 B VHL cells

CryoEM Structure of the Human FLCNFNIP2RagRagulator ComplexCell

Specificity of FLCNRagC GAP interaction in AFC A Nucleotidebinding

CryoEM Structure of the Human FLCNFNIP2RagRagulator Complex Cell

Figure 1 from CryoEM Structure of the Human FLCNFNIP2RagRagulator

Structural mechanism of a Rag GTPase activation checkpoint by the

The Folliculin Tumor Suppressor Is a GAP for the RagCD GTPases That

CryoEM Structure of the Human FLCNFNIP2RagRagulator Complex Cell

The Folliculin Tumor Suppressor Is a GAP for the RagCD GTPases That

Structural mechanism of a Rag GTPase activation checkpoint by the

AA stimulation drives transient localization of TFE3 to lysosome via

The Critical Role of FLCN TFE3 and TFEB in Bioenergetic and Nutrient

Specificity of FLCNRagC GAP interaction in AFC A Nucleotidebinding

Structural mechanism of a Rag GTPase activation checkpoint by the

Roberto ZONCU University of California Berkeley CA UCB

Structural Insights into TOR Signaling

SciencemTORC1

Emerging roles of the MiTTFE factors in cancer Trends in Cancer

Cystogenesis caused by Folliculin deletion in the developing kidney

Structural mechanism for amino aciddependent Rag GTPase nucleotide

RCSB PDB 6NZD CryoEM Structure of the Lysosomal Folliculin Complex

Frontiers Nutrient Signaling and Lysosome Positioning Crosstalk

CryoEM Structure of the Human FLCNFNIP2RagRagulator Complex Cell

Frontiers Nutrient Signaling and Lysosome Positioning Crosstalk

RCSB PDB 6NZD CryoEM Structure of the Lysosomal Folliculin Complex

mTORC1 介导的负反馈环路限制氨基酸诱导的 FLCN-Rag 在 TSC2 丢失的肾细胞中的激活,Nature ...

mTORC1 FLCNRag TSC2 Nature

CryoEM Structure of the Human FLCNFNIP2RagRagulator Complex

RCSB PDB 6NZD CryoEM Structure of the Lysosomal Folliculin Complex

GABARAP sequesters the FLCNFNIP tumor suppressor complex to couple

How does Folliculin Regulate mTORC1 Activity

RCSB PDB 6NZD CryoEM Structure of the Lysosomal Folliculin Complex

RagulatorRag and ROS TORment gasdermin D pore formation Trends in

Folliculin Contributes to VHL Tumor Suppressing Activity in Renal

CryoEM Structure of the Human FLCNFNIP2RagRagulator Complex Cell

RCSB PDB 6NZD CryoEM Structure of the Lysosomal Folliculin Complex

Induction of lysosomal and mitochondrial biogenesis by AMPK

RCSB PDB 6NZD CryoEM Structure of the Lysosomal Folliculin Complex

Folliculin FLCN regulates clear cell renal cell carcinoma ccRCC

An mTORC1mediated negative feedback loop constrains amino acidinduced

Other pathways and cellular processes regulated by FLCNFNIP

GABARAP sequesters the FLCNFNIP tumor suppressor complex to couple

Frontiers Folliculin A Regulator of Transcription Through AMPK and

The constitutively active Rag complex rescues TFE3 cytoplasmic

Histopathology of the most common malignant renal neoplasms a Clear

Noncanonical mTORC1 signaling at the lysosome Trends in Cell Biology

Nature mTORC1

AA stimulation drives transient localization of TFE3 to lysosome via

PDF GATOR1dependent recruitment of FLCNFNIP to lysosomes

TFEB phosphorylation and cytosolic retention requires active RagCD a

Loss of FLCNFNIP12 induces a noncanonical interferon response in

renameCSDN

FLCN a novel autophagy component interacts with GABARAP and is

RCSB PDB 6NZD CryoEM Structure of the Lysosomal Folliculin Complex

Recruitment of folliculin to lysosomes supports the amino acid

Folliculin impairs breast tumor growth by repressing TFE3dependent

Full article FLCN a novel autophagy component interacts with GABARAP

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