Fimh Function

Comparison of the structures of FimH before and after translocation a

Evolutionary finetuning of conformational ensembles in FimH during

Figure 1 from Rational design strategies for FimH antagonists new

Structural Basis for Mechanical Force Regulation of the Adhesin FimH

Catchbond mechanism of the bacterial adhesin FimH PMC

Binding site plasticity regulation of the FimH catchbond mechanism

Crystallographic analysis of FimH conformational states a

Schematic diagram of some of the constructs used in this work FimH R

FimH interdomain hydrogen bonding interactions Number of hydrogen

Carbohydrate recognition by the type 1 pilus adhesion FimH

Crystal structures and mannose binding of FimH variants in a tiplike

Positions 73 158 and 166 in the crystal structure of FimH in complex

FimH interdomain hydrogen bonding interactions Number of hydrogen

The structure of FimH cocrystallized with FimC Download Scientific

PDF The potential of FimH as a novel therapeutic target for the

The conformational state of FimH determines the mode of Download

Conformational switch of the bacterial adhesin FimH in the absence of

The conformational state of FimH determines the mode of Download

Folding of oxidized FimH L vs FimH P a Schematic representation of the

Frontiers Escherichia coli adhesion portion FimH polarizes M2

Catchbond mechanism for the shear forcedependent binding of FimH to

Structural insights into a cooperative switch between one and two FimH

FimH interdomain hydrogen bonding interactions Number of hydrogen

HM binding and release by the isolated FimH lectin domain FimHL

Schematic representation of evolutionary changes in the FimH binding

Positively selected FimH residues enhance virulence during urinary

a The threedimensional structure of the FimH receptorbinding domain

FimH Forms Catch Bonds That Are Enhanced by Mechanical Force Due to

Structural insights into a cooperative switch between one and two FimH

Catchbond mechanism for the shear forcedependent binding of FimH to

Thermodynamic model of the interaction of FimH with mannoside ligands

Proposed docked structure of FimH domains A crystal structure of FimH

Binding of the bacterial adhesin FimH to its natural multivalent high

fimH constructs in UTI89 fimH are expressed in some bacteria and

Alternative conformations of FimH On the left FimH from FimHGFFCTIP

Threedimensional structures of FimH and truncated forms of FimH a

Thermodynamic model of the interaction of FimH with mannoside ligands

Tertiary structure of fimH protein The structure was visualized by

Single cycle kinetics of FimH binding to immobilized BSA conjugates of

Unhinging pathway of FimH under tensile force in MD simulations a

Scheme of the interactions in the extended FimH receptorbinding

FimH adhesin of ETEC interacts with intestinal epithelial cells a

FimH functions as a mucosal adjuvant for the inhibition of lung

Construction of fimH chromosomal mutants A Construction of fimH

Proposed docked structure of FimH domains A crystal structure of FimH

Twodimensional LigPlot image of FimH complex generated by PDBsum

The binding poses of selected hits in the active site cavity of FimH

Antibodies induced by FimH immunization bind human glomerular

fimH constructs in UTI89 fimH are expressed in some bacteria and

Escherichia coli adhesion portion FimH functions as an adjuvant for

a Connolly surface of FimH in complex with FimC 8 The CRD known

Scheme of the interactions in the extended FimH receptorbinding

Conserved FimH mutations in the global Escherichia coli ST131 multi

FimH induces relatively low cytotoxicity in mice than LPS a Bone

FimH inhibition A Phase assay of UTI89 and fimH Q133K with or

Catchbond mechanism of the bacterial adhesin FimH PMC

Predicted structural model of the Salmonella FimH fimbrial adhesin The

Models for conformational dynamics A The inactive state of FimH with

Recombinant FimH Adhesin Demonstrates How the Allosteric Catch Bond

Conformational ensembles in Klebsiella pneumoniae FimH impact

Substituted sites on FimH alleles visualized on the Salmonella FimH

Tertiary structure of fimH protein The structure was visualized by

Application of a recombinant Escherichia coli overexpressing fimh gene

Role of fim recombinases in controlling phase state after FimH

Crystal structures and mannose binding of FimH variants in a tiplike

FimH is necessary and seemingly sufcient to mediate internalization

FimH protein expression on the surface of Salmonella Typhimurium

Integrinlike Allosteric Properties of the Catch Bondforming FimH

Crystal structure of FimH in complex with oligomannose3 The two FimH

Structural insights into a cooperative switch between one and two FimH

Bacterial Lectin FimH and Its Aggregation HotSpots An Alternative

FimH 52 and FimH 89 are highly conserved in sequence and structure A

The fim operon of UTI89 fimH is primarily in the phase off

FimH mutations influence adhesion to endothelial and urothelial cells

PPT Activatable Antibodies PowerPoint Presentation free download

TeamPittsburghDesign 2021igemorg

UTBye TechnionIsrael

Structural basis for adhesin secretion by the outermembrane usher in

Catchbond mechanism of the bacterial adhesin FimHNature

Structure of FimDFimCFimFFimGFimH a Crystal structure of

TeamNYMUTaipeiProjectAttachment 2008igemorg

E coli binds to Dmannose using FimH A Dmannose is a Download

TeamNYMUTaipeiProjectInhibitionProhibition 2013igemorg

Formation of the type 1 tip complex A The FimDFimCFimH complex

FimCFimH interactions with FimD in the FimDFimCFimH complexa b

Structurefunctiontreatment model of UPEC pathogenesis A Model of

FimHmannose bond mechanics A A typical AFM curve B Rupture force

Snapshot of a bacterial transporter in the act of secreting a protein

Week 3 March 2026 Antibody Allostery Evidence Mechanisms and

Mechanical stability of individual Fim domains a Schematic view of a

Research WUSTL Hultgren Lab

Structural rearrangements in FimH a Ribbon diagram of fulllength

Inhibition of in vitro DSE a SDSPAGE showing FimCFimH DSE with

Structural rearrangements in FimH a Ribbon diagram of fulllength

Schematic depiction of the POIFimH fusion protein to display a

Schematic representation of conformational states of FimH The pilin

The Conformational Variability of FimH Which Conformation Represents

BJOC Diazirinefunctionalized mannosides for photoaffinity labeling

FimHcontaining thermally responsive nanoparticles FTRH promoted the

Recombinant Escherichia coli Outer membrane usher protein fimD Gentel

Frontiers Perinatal derivatives How to best validate their

Characterization of FimHcontaining thermally responsive nanoparticles

Research WUSTL Hultgren Lab

PPT Insights into the Structural Organization of FimDFimCFimFFimG

The genetic organization of the S Typhimurium fim gene cluster and a

Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric

UTBye TechnionIsrael

Structurebased design of an immunogenic conformationally stabilized

FimHbound structure of the uroplakin complex a Map and fitted models

FimHcontaining thermally responsive nanoparticles FTRH promoted the

Predicted threedimensional models of Salmonella FimH Shown is a

Figure 2 from An insilico study of selected mannose derivatives against

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