Col2 Cre

Cre lines based on the use of the Sox9 Acan Col2 and Col10

Reduced chondrocyte proliferation in Col2 CreDicer flfl mice cKO

Ablation of Col2 cells results in absence of the spine and disruption

The Col2 a 1Cre promoter is active in Nf1 floxflox Download

Osx and Col2 progenitor cell populations are located in developing

SOC osteogenic tissue arises from Col2 chondrocytes AI Lineage

Reduced chondrocyte proliferation in Col2 CreDicer flfl mice cKO

Ablation of Col2 cells results in absence of the spine and disruption

Disruption cilia structure to block Hh signaling in Col2 chondrocytes

Comparative Evaluation of Inducible Cre Mouse Models for Fibroblast

The sera reactivity to cyclic COL2 peptides and native triplehelical

Ablation of Col2 cells results in absence of the spine and disruption

Col2Cre and Col2CreER gene construct Col2Cre gene includes a 3 kb

Sagittal section of Col2CretdTomato or Col2CreERtdTomato 6week old

Spatial distribution of type II collagen gene expression in the mouse

Col2CreTsc1 flfl mice develop abnormally but their bones are

Deletion of Bmpr1a with Col2Cre disrupts chondrocyte maturation and

Dicer is required for normal skeletal development A Skeletal

Molecular composition of articular cartilage is disrupted in

Phenotype of MMP13flflCol2Cre endochondral bones AB

Deletion of Bmpr1a with Col2Cre disrupts chondrocyte maturation and

Sagittal section of Col2CretdTomato or Col2CreERtdTomato 6week old

Col2Cre and Col2CreER gene construct Col2Cre gene includes a 3 kb

A Subset of Chondrogenic Cells Provides Early Mesenchymal Progenitors

Evaluating Col2cre activity and tissuespecific deletion of Lrp5 and

Type II collagen was reduced with Erk signal suppression in Col2RB1CC1

Col23Cre and Col36Cre mice were bred with GFP ROSA reporter mice

Col2Cre recombinase is coexpressed with endogenous type II collagen

Inhibition of YAP signaling delays chondrosarcoma progression in

Col2Cre recombinase is coexpressed with endogenous type II collagen

Col2Cre and tamoxifeninducible Col2CreER target different cell

Col2Cre lineage cellderived VEGF is required for articular

Deletion of Bmpr1a with Col2Cre disrupts chondrocyte maturation and

Col2Cre lineage cellderived VEGF is required for articular

Cartilage tissues regulate systemic aging via ectonucleotide

Col2Cre ERT cells do not populate the developing tendon enthesis

CXCL12 Col2cre mice develop an ankylosis phenotype A and B CT

Analyses of Col2CreIhh R26 DNGli2 DNGli2rescue embryos at

Attenuation of Col2Cre lineage cellderived VEGF induces cell death in

Adult Col2creLrp5FlFL 5cKO or Col2creLrp6FlFL 6cKO mice and

Col2CreTsc1 flfl mice develop abnormally but their bones are

Cartilage tissues regulate systemic aging via ectonucleotide

Col2CretdTomato 6week old mouse lower lumbar and coccygeal spine

Col2Cre lineage cellderived VEGF is required for articular

Type II collagen was reduced with Erk signal suppression in Col2RB1CC1

Col2creLrp5FlFLLrp6FlFL 5cKO6cKO mice have altered

Col2Cre and tamoxifeninducible Col2CreER target different cell

Col2Cre recombinase is coexpressed with endogenous type II collagen

Credeleter

MEF2C Transcription Factor Controls Chondrocyte Hypertrophy and Bone

Deletion of TAZ in chondrocytes impairs bone development a

Cre

Cartilage tissues regulate systemic aging via ectonucleotide

Deletion of TAZ in chondrocytes inhibits growth plate and articular

The Contribution of Meckels CartilageDerived Type II Collagen

Adult mice carrying Col2cremediated deletions of Lrp5 andor Lrp6

Analyses of Col2CreIhh R26 DNGLi2 DNGli2rescue embryos at

Spatial distribution of type II collagen gene expression in the mouse

Analyses of Col2CreIhh R26 DNGLi2 DNGli2rescue embryos at

Deletion of Bmpr1a with Col2Cre disrupts chondrocyte maturation and

Impaired Annulus Fibrosus Development and Vertebral Fusion Cause Severe

Lin28a overexpression decreases proliferation and increases cell death

Deletion of Trp53 and Rb1 in chondrocytes causes spinal chondrosarcoma

CT analysis of cortical bone in Col23CreJag1 ff mice at 2 months

Deletion of Bmpr1a with Col2Cre disrupts chondrocyte maturation and

Col2Cre ERT cells do not populate the developing tendon enthesis

CD 146 and CD 166 cells were marked by Col23GFP or Osx1CreGFP

Chondrocyteintrinsic Smad3 is required for maintenance of articular

Col2Cre ERT cells do not populate the developing tendon enthesis

Col2RB1CC1 causes dwarfism in mice A Col2RB1CC1 RB1CC1Cre mice

CT analysis of cortical bone in Col23CreJag1 ff mice at 2 months

Generation of Col2RB1CC1 transgenic mice A the Neo gene was flanked

Tracing the skeletal progenitor transition during postnatal bone

Cbf ff Col21Cre mice had impaired endochondral bone formation A

Generation of Col2RB1CC1 transgenic mice A the Neo gene was flanked

CT analysis of trabecular bone in Col23CreJag1 ff mice at 2 months

Design and characterization of a novel genetically engineered mouse

Apoptosis and angiogenesis in Osterix knockout mice A flox and

Higher magnification views of Col2creLrp5FlFLLrp6FlFL 5cKO6cKO

Deletion of Trp53 and Rb1 increases the expansion and differentiation

OsxCre targets osteoblast lineage cells hypertrophic chondrocytes and

A Subset of Chondrogenic Cells Provides Early Mesenchymal Progenitors

Deletion of Bmpr1a with Col2Cre disrupts chondrocyte maturation and

Dicerdependent pathways regulate chondrocyte proliferation and

Type II collagenpositive progenitors are important stem cells in

Deletion of Foxp124 by Col2Cre advanced mineralization and

CT analysis of trabecular bone in Col23CreJag1 ff mice at 2 months

Chondrocyte‐Specific Knockout of the G Protein Gsα Leads to Epiphyseal ...

ChondrocyteSpecific Knockout of the G Protein Gs Leads to Epiphyseal

Dicerdependent pathways regulate chondrocyte proliferation and

Deletion of Bmpr1a with Col2Cre disrupts chondrocyte maturation and

Reduced chondrocyte proliferation and chondrodysplasia in mice lacking

Adult mice carrying Col2cremediated deletions of Lrp5 andor Lrp6

CT analysis of cortical bone in Col23CreJag1 ff mice at 2 months

Type II collagenpositive progenitors are important stem cells in

Deletion of Bmpr1a with Col2Cre disrupts chondrocyte maturation and

Spatial distribution of type II collagen gene expression in the mouse

Deletion of both Vegf alleles in tamoxifeninduced Col2CreER mice does

ChondrocyteSpecific Knockout of the G Protein Gs Leads to Epiphyseal

Constitutive and conditional gene knockout mice for the study of

FoxA Family Members Are Crucial Regulators of the Hypertrophic

Indian Hedgehog produced by postnatal chondrocytes is essential for

A mouse model of chondrocytespecific somatic mutation reveals a role

TAZ is required for chondrogenesis and skeletal development PMC

ChondrocyteSpecific Knockout of the G Protein Gs Leads to Epiphyseal

Type II collagenpositive progenitors are important stem cells in

FoxA family members are crucial regulators of the hypertrophic

Prolyl Hydroxylase DomainContaining Protein 2 Phd2 Regulates

Alterations in matrix protein expression cell proliferation and

Chondrocytes expressing intracellular collagen type II enter the cell

let7 and miR140 microRNAs coordinately regulate skeletal development

H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for

Tamoxifeninducible Crerecombination in articular chondrocytes of

Specific Deletion of β-Catenin in Col2-Expressing Cells Leads to ...

Specific Deletion of Catenin in Col2Expressing Cells Leads to

TDT Col2 CRE Tamoxifen Mice Construct

Col2 Target Chondrocyte

Vav1 CRE

Col2 Plane

Growth Plate Col2

Immunofluorescence Staining of Col2

Immunofluorescence of Col2 in Cartilage

Col1 Staining

Col2

Col2 Staining

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