Cdc7

CDC7 cell division cycle 7

Cdc7 kinase A new target for drug development European Journal of

Figure 12 from The role of Cdc7 and cyclindependent kinases in DNA

Structural Basis for the Activation and Target Site Specificity of CDC7

PDF Drug design with CDC7 kinase A potential novel cancer therapy target

Cdc7 inhibitor for the treatment of cancer Cancer Biology

Crystal structure of human CDC7 kinase in complex with its activator

Dissection of human Cdc7 kinase two segments DAM1 and DAM2

Structural Basis for the Activation and Target Site Specificity of CDC7

Dissection of human Cdc7 kinase two segments DAM1 and DAM2

Cdc7 promotes OSCC cell proliferation and tumourigenesis a The Cdc7

Nuclei prepared from cells blocked in late Glphase with the cdc7

Cdc7 regulation of DNA replication and checkpoints in normal and tumor

Cdc7 promotes OSCC cell proliferation and tumourigenesis a The Cdc7

Molecular Mechanism of Activation of Human Cdc7 Kinase Journal of

Dbf4Dependent Cdc7 Kinase Links DNA Replication to the Segregation of

Dbf4 and Cdc7 Proteins Promote DNA Replication through Interactions

Molecular Mechanism of Activation of Human Cdc7 Kinase Journal of

CDC7 Gene GeneCards CDC7 Protein CDC7 Antibody

DNA replication in vertebrates requires a homolog of the Cdc7 protein

Cdc7 induced SMC differentiation independent of Dbf4 A Dbf4

Cdc7 fulfills its essential function early in S phase ab G1 CHO

CDC7 Gene GeneCards CDC7 Protein CDC7 Antibody

Both Xenopus Cdc7 complexes have kinase activities but only XCdc7Drf1

Stressinduced CDC7 Proteolysis is Mediated by Fbxw7b and GSK3b kinase

Dbf4Dependent Cdc7 Kinase Links DNA Replication to the Segregation of

Cdc7 is required throughout the yeast S phasetoactivatereplication origins

Cdc7 promotes OSCC cell proliferation and tumourigenesis a The Cdc7

Structural simplification of CDC7 kinase inhibitors A and the binding

The Role of Dbf4Drf1Dependent Kinase Cdc7 in DNADamage Checkpoint

Cdc7 functionally interacted with Nkx2 5 to regulate Myocd

Structural Basis for Substrate Binding by CDC7 Download Scientific

Molecular Mechanism of Activation of Human Cdc7 Kinase Journal of

Dbf4Dependent Cdc7 Kinase Links DNA Replication to the Segregation of

PLK1 inhibition blocks CDC7 transactivation via MYC signaling A Box

Molecular Mechanism of Activation of Human Cdc7 Kinase Journal of

CDC7 Gene GeneCards CDC7 Protein CDC7 Antibody

Cdc7 overexpression promotes homologous recombination HR DNA repair

Mapping of the segments of Cdc7 required for interaction with ASK A

Cdc7 activates replication checkpoint by phosphorylating the Chk1

CDC7 Gene GeneCards CDC7 Protein CDC7 Antibody

Stressinduced CDC7 Proteolysis is Mediated by Fbxw7b and GSK3b kinase

DNA replication in vertebrates requires a homolog of the Cdc7 protein

CDC7 inhibition impairs neuroendocrine transformation in lung and

Molecular Mechanism of Activation of Human Cdc7 Kinase Journal of

Dbf4 and Cdc7 Proteins Promote DNA Replication through Interactions

Dbf4Dependent Cdc7 Kinase Links DNA Replication to the Segregation of

Cdc7 regulates Cul4DDB1 Cdt2 mediated Tob degradation and DNA

Dbf4 and Cdc7 Proteins Promote DNA Replication through Interactions

DNA replication in vertebrates requires a homolog of the Cdc7 protein

Dbf4Dependent Cdc7 Kinase Links DNA Replication to the Segregation of

$Cdc7 kinase complexes accumulate in a chromatin-enriched fraction upon ...$

Cdc7 kinase complexes accumulate in a chromatinenriched fraction upon

DNA replication in vertebrates requires a homolog of the Cdc7 protein

MVMinduced replication stress is reversible by CDC7 inhibition A

Human and yeast Cdc7 and Dbf4Drf1 A Comparison of the primary

DNA replication in vertebrates requires a homolog of the Cdc7 protein

Dbf4Dependent Cdc7 Kinase Links DNA Replication to the Segregation of

DNA metabolism gene CDC7 from yeast encodes a serine threonine

Phosphorylation of Mcm2 by Cdc7 Promotes Prereplication Complex

Stressinduced Proteolysis of CDC7 is Dependent on CDC4type

Cdc7 regulates Cul4DDB1 Cdt2 mediated Tob degradation and DNA

Characteristics and expression of CDC7 in cervical cancer

Cdc7 induced SMC differentiation independent of Dbf4 A Dbf4

RCSB PDB 4F9A Human CDC7 kinase in complex with DBF4 and nucleotide

Slide 28

Smallmolecule Articles Smolecule

Journal of Cellular Physiology Cell Biology Journal Wiley Online

Schematic drawing of structures of Cdc7related kinase catalytic

Druggable cavities and allosteric modulators of the cell division cycle

DDK The Outsourced Kinase of Chromosome Maintenance

Journal of Cellular Physiology Cell Biology Journal Wiley Online

CDKS and Cdc7Dbf4 regulate DSB formation via phosphorylation of Mer2

Cdc7independent G1S transition revealed by targeted protein

Full article Druggable cavities and allosteric modulators of the cell

Schematic drawing of structures of Cdc7related kinase catalytic

Druggable cavities and allosteric modulators of the cell division cycle

PDF Druggable cavities and allosteric modulators of the cell division

The AnCdc7 kinase is predominantly nuclear during interphase and

Sequence of the predicted cdc 7 protein The DNA sequence of both

Superposition of the pockets 2 4 6 and 9 with the human CDC7DBF4

CDC7independent G1S transition revealed by targeted protein

Cdc7independent G1S transition revealed by targeted protein

Cdc7Dbf4 Regulates NDT80 Transcription as Well as Reductional

CDC7independent G1S transition revealed by targeted protein

Cdc7Dbf4 Phosphorylates MCM Proteins via a Docking SiteMediated

Cdc7Dbf4 Regulates NDT80 Transcription as Well as Reductional

Figure 2 from Structural Basis for the Activation and Target Site

Cdc7Dbf4 Regulates NDT80 Transcription as Well as Reductional

CDC7independent G1S transition revealed by targeted protein

The structural basis of Cdc7Dbf4 kinase dependent targeting and

Cdc7Drf1 is a developmentally regulated protein kinase required for

Rif1 controls DNA replication by directing Protein Phosphatase 1 to

The Cdc7Dbf4 protein kinase target of the S phase checkpoint EMBO

Keeping everything in order RIKEN

Cdc7Drf1 kinase links chromosome cohesion to the initiation of DNA

Cdc7mediated phosphorylation of Cse4 regulates highfidelity

Essential Role of Phosphorylation of MCM2 by Cdc7Dbf4 in the

CDC7independent G1S transition revealed by targeted protein

The Dbf4Cdc7 kinase promotes S phase by alleviating an inhibitory

Details of the DBF4 structure and its interface with CDC7a DBF4

CDC7independent G1S transition revealed by targeted protein

Cdc7Dbf4 Phosphorylates MCM Proteins via a Docking SiteMediated

Structure of the CDC7DBF4 heterodimer and a view on the active

RCSB PDB 7PT6 Structure of MCM27 DH complexed with Cdc7Dbf4 in the

Journal of Cellular Physiology Cell Biology Journal Wiley Online

Kinetochores Coordinate Pericentromeric Cohesion and Early DNA

The Dbf4Cdc7 Kinase Promotes Mcm27 Ring Opening to Allow for Single

Cdc28Clb5 CDKS and Cdc7Dbf4 DDK collaborate to initiate meiotic

Cdc7Dbf4 Regulates NDT80 Transcription as Well as Reductional

Dual Role of the Cdc7regulatory Protein Dbf4 during Yeast Meiosis

CDC7DBF4 interacts with TOP2A A Proteins extracted from nuclei with

The structural basis of Cdc7Dbf4 kinase dependent targeting and

The Dbf4Cdc7 kinase promotes S phase by alleviating an inhibitory

The Dbf4Cdc7 Kinase Promotes Mcm27 Ring Opening to Allow for Single

DNA Replication Cell Cycle

G2 Checkpoint Cell Cycle

P53 Cell Cycle Checkpoint

Complementation Assay

Molecular Cell

TOP2A

Eukaryotic DNA Replication

Cancer Cell Metabolism

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