Cbl B

Cbl Ubiquitin Ligases Control B Cell Exit from the GerminalCenter

Figure 1 from Regulation of immune responses by E3 ubiquitin ligase Cbl

Lymphocyte signaling Cbl sets the threshold for autoimmunity Current

Figure 1 from Regulation of immune responses by E3 ubiquitin ligase Cbl

Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T

Ubiquitination and CBL

Schematic representation of Cbl protein structure a Protein domains of

Proteomic investigation of Cbl and Cblb in neuroblastoma cell

E3 ubiquitin ligase Casitas B lineage lymphomab and its potential

The Cbl Family Ubiquitin Ligases Regulating Signaling by Tyrosine

Cbl protein family in mammals cCbl Cblb and Cbl3 Drosophila

Lymphocyte signaling Cbl sets the threshold for autoimmunity Current

The Cbl Family and Other Ubiquitin Ligases Immunity

Domain structures of the Cbl family members in mammals Both cCbl and

The Cbl family of ubiquitin ligases a Domain architecture of cCbl

Cbl and Cblb ubiquitin ligases are essential for intestinal epithelial

The Cbl Family and Other Ubiquitin Ligases Immunity

CBL autoinhibition through the E2binding site a Interactions in

Comparison of the CBL and CBLB signalosomes of peripheral CD4 T

Frontiers The role of CBL family ubiquitin ligases in cancer

Stable knockdown of the ubiquitin E3 ligases cCbl and Cblb in A20WT B

E3 ubiquitin ligase Casitas B lineage lymphomab and its potential

The mammalian Cbl protein family Schematic representation of the

Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T

A model of the LHRmediated regulation of Cbl proteins A A schematic

Figure 1 from Ubiquitin Ligases CBL and CBLB Maintain the Homeostasis

Structures of Cbl protein family switching between an active Tyr363

The Cbl Family and Other Ubiquitin Ligases Immunity

Ensemble of CBL structures a Diagram of the crystallized CBL

Structures of 3mCblbC7683 and other Cbl family proteins in active and

Structure of the Cbl family proteins The original oncogenic form of

Cbl and Cblb independently regulate EGFR through distinct receptor

Conservation of structure in the Cbl family of proteins The comparison

Frontiers Ubiquitin Ligases CBL and CBLB Maintain the Homeostasis

The Cbl Family and Other Ubiquitin Ligases Immunity

The Cbl family of ubiquitin ligases regulates FcεRI expression and mast ...

The Cbl family of ubiquitin ligases regulates FcRI expression and mast

From Structure to Function Cblb Inhibition in Cancer Immunotherapy

Structure of the CBL CBLb and CBLc proteins with the relative

Frontiers Modulation of Immune Cell Functions by the E3 Ligase Cblb

Cblb Roles in T Cell Tolerance Proallergic T Cell Development and

Full article CBLB An upcoming immuneoncology target

Build It They Will Come Momentum Building For CBLB Inhibition

Targeting Cblb in cancer immunotherapy Journal for ImmunoTherapy of

The cartoon representation of CBLB protein bound with ligand with the

Slide 8

First in class的 RING E3 连接酶(CBL-B)抑制剂筛选与设计 - 知乎

First in class RING E3 CBLB

Xray crystal structure of Cblb Nterminal fragment bound to C7683

Slide 10

Frontiers Targeting the CblbNotch1 axis as a novel

CBLB

E3 Ubiquitin Ligase Cblb Suppresses Proallergic T Cell Development and

Deciphering the Selectivity of CBLB Inhibitors Using AllAtom

First in class RING E3 CBLB

TCR signaling promotes formation of an STS1Cblb complex with pH

Mechanisms of CblMediated Ubiquitination of Proteins in T and Natural

Slide 9

Full article CBLB An upcoming immuneoncology target

Inhibition of Cblb restores effector functions of human intratumoral

Autoinhibition and phosphorylationinduced activation mechanisms of

Frontiers E3 Ubiquitin Ligases as Immunotherapeutic Target in

SPARK Cblb

Cblb ubiquitylation and proteasomal degradation mediated by Nedd4 A

Cblb Is a Negative Regulator of Receptor Clustering and Raft

The cocrystal structure of Cblb and a smallmolecule inhibitor

Mechanisms of CblMediated Ubiquitination of Proteins in T and Natural

78821 CBLBDriven AXL Ubiquitination Intrachain TRFRET A

Structural Basis for UbiquitinMediated Dimerization and Activation of

First in class RING E3 CBLB

Figure 1 from The Roles of Cblb and cCbl in Insulinstimulated

Increased expression of Cblb and cCbl during NK cell inhibition

cCbl and Cblb ubiquitin ligases substrate diversity and the negative

Figure 2 from cCbl and Cblb ubiquitin ligases substrate diversity

The cartoon representation of CBLB protein bound with ligand with the

Degradation of activated protein kinases by ubiquitination Abstract

PDF The cocrystal structure of Cblb and a smallmolecule inhibitor

Autoinhibition and phosphorylationinduced activation mechanisms of

Schematic representation of the proposed model A The E3 ubiquitin

Increased expression of Cblb and cCbl during NK cell inhibition

cCbl An Important Regulator and a Target in Angiogenesis and

Platforms targeting Cblb currently in development or under

Frontiers Targeting the CblbNotch1 axis as a novel

Figure 1 from The Roles of Cblb and cCbl in Insulinstimulated

Cblb expression negatively correlates with MKK4 protein level and

The key amino acids in the binding pocket and their importance in

The cocrystal structure of Cblb and a smallmolecule inhibitor

Inhibition of Cblb restores effector functions of human intratumoral

Structural Basis for UbiquitinMediated Dimerization and Activation of

Structure of the CBL CBLb and CBLc proteins with the relative

Novel Lactams as Cblb Inhibitors for Treating Cancer ACS Medicinal

The E3 Ligase Cblb and TAM receptors regulate cancer metastasis via

Novel Lactams as Cblb Inhibitors for Treating Cancer ACS Medicinal

Frontiers Targeting the CblbNotch1 axis as a novel

A Schematic representation of different Cblb mutants that were used

First in class RING E3 CBLB

Involvement of Cblbmediated macrophage inactivation in insulin resistance

Cblb ubiquitinates and degrades Notch1 A B Notch1 or Cblb

The c-Cbl Ubiquitin Ligase Regulates Nuclear β-Catenin and Angiogenesis ...

The cCbl Ubiquitin Ligase Regulates Nuclear Catenin and Angiogenesis

Autoinhibition and phosphorylationinduced activation mechanisms of

The CBLrelated Protein CBLB Participates in FLT3 and Interleukin7

Figure 2 from Novel cCBL and CBLb ubiquitin ligase mutations in human

Figure 1 from The Roles of Cblb and cCbl in Insulinstimulated

The E3 ubiquitin ligase Cblb improves the prognosis of RANK positive

Inhibition of Cblb restores effector functions of human intratumoral

The E3 ubiquitin ligase Cblb improves the prognosis of RANK positive

Putative mechanism of gain of function of cCBL mutants A after

Frontiers Targeting the CblbNotch1 axis as a novel

Nurix Therapeutics launches CBLB inhibitor Drug Hunter posted on the

E3 Ubiquitin ligases Cblb and cCbl maintain the homeostasis of

Structural Basis for UbiquitinMediated Dimerization and Activation of

Frontiers Modulation of Immune Cell Functions by the E3 Ligase Cblb

CblbIN3 Cblb inhibitors TargetMol

Cblb inhibitor NX1607 activates MAPKERK signaling pathway and

Cblb

CBLB

Cblb a RINGtype E3 Ubiquitin Ligase Targets Phosphatidylinositol 3

CblbIN8 CblbcCbl Inhibitor MedChemExpress

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