Apc Axin Complex

APC and Axin have regions with potentially redundant functions and

Reconstitution of the destruction complex defines roles of AXIN

11 The APC signaling pathway In a normal cell APC forms a complex

Model for the role of APC selfassociation in promoting Axin puncta

The essential regions in APC and Axin each make important but partially

Complex formation of APC and GSK3 through Axin A in vitro Purified

Association of APC fragments with Axin and catenin in vitro The RGS

Simplified model showing differential Axin complex formation for its

Complex Formation of Adenomatous Polyposis Coli Gene Product and Axin

Model for the role of APC selfassociation in promoting Axin puncta

Axin binds to APC and induces APC phosphorylation in vivo A Diagram

(PDF) APC mutations disrupt β-catenin destruction complex condensates ...

PDF APC mutations disrupt catenin destruction complex condensates

Effects of phosphorylation of APC by CKI on its complex formation with

Apc promotes Axin proteolysis AC Wing disc expressing AxinV5

MACF1 acts upstream of GSK3 and associates with the Axin complex at the

PDF Reconstitution of the destruction complex defines roles of AXIN

APC mutations disrupt β-catenin destruction complex condensates ...

APC mutations disrupt catenin destruction complex condensates

APC and axin mediatecatenin cytoplasmic accumulation by a CRM1

APC mutations disrupt catenin destruction complex condensates

Complex Formation of Adenomatous Polyposis Coli Gene Product and Axin

Loss of function of the tumor suppressors Axin or APC trigger

The destabilization of Axin by APC is conserved in vertebrates A

Phase separation of Axin organizes the β-catenin destruction complex - PMC

Phase separation of Axin organizes the catenin destruction complex PMC

Axin binds to APC and induces APC phosphorylation in vivo A Diagram

APC mutations disrupt catenin destruction complex condensates

APC and axin mediatecatenin cytoplasmic accumulation by a CRM1

APC displaces Dvl2 from Axin assemblies Single confocal sections

APC mutations disrupt catenin destruction complex condensates

Complex Formation of Adenomatous Polyposis Coli Gene Product and Axin

APC mutations disrupt catenin destruction complex condensates

Building a complex for destruction Molecular Cell

Schematic drawing modified from 20 of the destruction complex

The Chimera mimics the APC2Axin complex in internal structure and

Axin domains molecular interactions and their functio Openi

Identification of ICAT as an APC Inhibitor Revealing WntDependent

Regulation of catenin Axin acts as a scaffolding protein that binds

A Schematic representations of vertebrate APC bcat and Axin with

APC is essential for the assembly of functional AxinGFP degradasomes

Axin facilitates the ubiquitinmediated degradation of APC A the

APC is detected in the AxinMEKK1catenin complex A APC has no effect

APC1338 phosphorylation and its competition with Axin for A level

1433s reduces bcatenin association with the APCaxinGSK3b complex

A In the absence of a WNT signal a multiprotein complex consisting

APC is detected in the AxinMEKK1catenin complex A APC has no effect

The Oligomerization Domains of the APC Protein Mediate LiquidLiquid

Frontiers Emerging roles of Axin in cerebral cortical development

Crystal Structure of a β-Catenin/APC Complex Reveals a Critical Role ...

Crystal Structure of a CateninAPC Complex Reveals a Critical Role

Identification of ICAT as an APC Inhibitor Revealing WntDependent

AXIN1 polymerization and APC regulate kinase activity in the DC Kinetic

A Schematic representations of vertebrate APC bcat and Axin with

APC protein undergoes LLPS A Axin1 KO HEK293T cells KO1

Dvl DIX oligomerization in Axin recruitment upon Wnt signaling Upper

Endogenous APC2 and Axin proteins accumulate at similar levels A mRNA

Loss of APC binding causes loss of AxinGFP function in Drosophila

Axin facilitates the ubiquitinmediated degradation of APC A the

AXIN1 polymerization and APC regulate kinase activity in the DC Kinetic

Interaction among GSK3 GBP axin and APC in Xenopus axis

Interaction of DOCK4 with catenin degradation complex enhances

Truncated APC in colon cancer cells is functional a Silencing of

Mechanism of Phosphorylation-Dependent Binding of APC to β-Catenin and ...

Mechanism of PhosphorylationDependent Binding of APC to Catenin and

APC undergoes LLPS and promotes Axin1 condensate formation A and B

The Axin1 core complex sustains catenin phosphorylation in APCmutant

Axin facilitates the ubiquitinmediated degradation of APC A the

Multivalent APC IDRs decrease the critical concentration of Axin1 for

Working model The interactions between the 20R2 of APC and amino acids

The Axin1 core complex sustains catenin phosphorylation in APCmutant

APC binding is required for efficient AxinGFP degradasome assembly in

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin ...

Functional Interaction of an Axin Homolog Conductin with Catenin

Crystal structure of a TankyraseAxin complex and its implications for

When You Come to a Fork in the Road Take It Wnt Signaling Activates

The Axin Apc catenin complex Download Scientific Diagram

PDF Molecular Biology of Cancer

The Axin Apc catenin complex Download Scientific Diagram

6 The Wnt signalling pathway In the absence of Wnt ligands the

The CanonicalWnt signaling pathway A In the absence of Wnt the

When You Come to a Fork in the Road Take It Wnt Signaling Activates

Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact ...

Wnt Signaling through Inhibition of Catenin Degradation in an Intact

When You Come to a Fork in the Road Take It Wnt Signaling Activates

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases ...

WntCatenin Signaling Components Mechanisms and Diseases

In the absence of Wnt proteins, Axin, APC, β-catenin, and GSK3B form a ...

In the absence of Wnt proteins Axin APC catenin and GSK3B form a

PDF When You Come to a Fork in the Road Take It Wnt Signaling

Enhancement of the GSK3 dependent phosphorylation of catenin by the

Wnt Signaling through Inhibition of Catenin Degradation in an Intact

| Axin-GSK3β signaling regulates neuronal polarization during neuronal ...

AxinGSK3 signaling regulates neuronal polarization during neuronal

APC Current Biology

The Wnt/β‐catenin signaling pathway. APC, An antigen‐presenting cell ...

The Wntcatenin signaling pathway APC An antigenpresenting cell

The canonical Wntcatenin pathway A In absence of Wnt signal the

A working model for the destruction complex 1 Initially the

WIP Is Located in Endosomal Compartments and Requires the Download

Schematic representation of Wnt pathway inhibition by small molecule

Structural basis for recruitment of glycogen synthase kinase 3β to the ...

Structural basis for recruitment of glycogen synthase kinase 3 to the

Canonical Wnt signaling pathway a In the absence of Wnt the Wnt

Adenomatous Polyposis Coli APC Regulates Multiple Signaling Pathways

Deconstructing the ßcatenin destruction complex: mechanistic roles for ...

Deconstructing the catenin destruction complex mechanistic roles for

PDF Structural basis for recruitment of glycogen synthase kinase 3

$Distinct fractionation pattern of components of the β-catenin ...$

Distinct fractionation pattern of components of the catenin

Molecular mechanisms of GSK-3β regulation. (a) The Wnt canonical ...

Molecular mechanisms of GSK3 regulation a The Wnt canonical

Wnt Signaling through Inhibition of Catenin Degradation in an Intact

Mechanistic model of Wnt signaling and involvement of hPAF complex a

Wnt/β-catenin signaling pathway. The left side shows signaling in the ...

Wntcatenin signaling pathway The left side shows signaling in the

Wnt signaling pathway A Canonical Wnt catenin pathway when there

Illustration of the canonical Wnt signaling pathway a Inactivated

A WntbCatenin Signaling in Cells Without the Wnt signal the

The Wnt/β-catenin signaling pathway. (A) In the Wnt-off state, the ...

The Wntcatenin signaling pathway A In the Wntoff state the

Transcriptional Regulation of Wnt/β-Catenin Pathway in Colorectal ...

Transcriptional Regulation of WntCatenin Pathway in Colorectal

The Axin Apc catenin complex Download Scientific Diagram

Schematic representation of WNTdependent bcatenin signaling In the

Structural basis for recruitment of glycogen synthase kinase 3 to the

AXINAMPK signaling Implications for healthy aging F1000Research

Frontiers Making sense of Wnt signalinglinking hair cell

Structural basis for recruitment of glycogen synthase kinase 3 to the

PPT SIGNALING PATHWAYS IN CANCER PowerPoint Presentation free

Molecular regulation and pharmacological targeting of the β‐catenin ...

Molecular regulation and pharmacological targeting of the catenin

Dysregulation of Wnt/β‐catenin signaling by protein kinases in ...

Dysregulation of Wntcatenin signaling by protein kinases in

Cancer genetics Tumor suppressor meets oncogene Current Biology

Adenomatous Polyposis Coli APC Regulates Multiple Signaling Pathways

Frontiers Advances and Insights of APCAsef Inhibitors for Metastatic

Apc Beta-Catenin Pathway

Wnt Receptor

Apc Protein

Beta-Catenin Structure

Wnt Β-Catenin Pathway

Wnt Ligands

Apc Axin Ghsk 3 Beta Complex

Canonical Wnt Signaling Pathway

Gsks3 Axon

GSK3B B-Catenin

Wnt Signaling Hair

E-cadherin and Beta Catenin

The Structure of AXIN1

Axin2 Staining

B-Catenin Destruction Complex

Stabilized Axin Wnt Tnks

Beta-Catenin Degradation

Wnt Protein Family

Wnt B-Catenin

APC Mutation Colon Cancer

Catenin

Wnt Protein

Canonical Wnt Signaling

Apc Tumor Suppressor Gene

B-Catenin GSK-3

Wnt Signaling Inhibitor

Wnt Beta-Catenin Signaling

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