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![Mitochondrial [4Fe-4S] protein assembly involves reductive [2Fe-2S ...](https://www.pnas.org/cms/10.1073/pnas.2003982117/asset/5798b89c-a5ff-408a-a607-be2925262c2c/assets/images/large/pnas.2003982117fig07.jpg)
![| The damage caused to [4Fe-4S] 2+ cluster enzymes by hydrogen ...](https://www.researchgate.net/publication/351126954/figure/fig2/AS:1023046987042816@1620924817351/The-damage-caused-to-4Fe-4S-2-cluster-enzymes-by-hydrogen-peroxide-The-catalytic-Fe.png)

![[4Fe-4S] cluster oxidation and disassembly on exposure of FNR to oxygen ...](https://www.researchgate.net/profile/Elizabeth-Theil/publication/23485547/figure/fig1/AS:310191540195328@1450966834370/figure-fig1_Q640.jpg)

![The most common structures and oxidation levels of [2Fe–2S], [3Fe–4S ...](https://www.researchgate.net/profile/Prabhuodeyara-M-Gurubasavaraj/publication/275208371/figure/fig7/AS:267891450839069@1440881707488/The-most-common-structures-and-oxidation-levels-of-2Fe-2S-3Fe-4S-and-4Fe-4S.png)
+%2B3O2+(g)+%EF%83%A0+2Fe2O3+(s).jpg)


![Superposition of the [4Fe-4S] cluster binding regions in three ...](https://www.researchgate.net/profile/Christopher-Bonagura/publication/11649575/figure/fig1/AS:409315820228608@1474599904306/Superposition-of-the-4Fe-4S-cluster-binding-regions-in-three-ferredoxins-with-differing.png)

![A designed heme-[4Fe-4S] metalloenzyme catalyzes sulfite reduction like ...](https://www.science.org/cms/asset/5088e189-73bf-4cd0-bd7e-3c3819d7aee2/361_1098_f1.gif)
![[4Fe-4S] cluster oxidation and disassembly on exposure of FNR to oxygen ...](https://www.researchgate.net/publication/23485547/figure/fig4/AS:667806404194316@1536228862613/4Fe-4S-cluster-oxidation-and-disassembly-on-exposure-of-FNR-to-oxygen-see-text-for.png)
![理解[4Fe-4S]簇组装对真核线粒体和胞质乌头酸酶的作用机理,Inorganic Chemistry - X-MOL](https://xpic.x-mol.com/20190823%2F10.1021_acs.inorgchem.9b01278.jpg)
![Structure of the [4Fe-4S] cluster-binding domain and active site in ...](https://www.researchgate.net/publication/274407334/figure/download/fig4/AS:272078196703247@1441879905374/Structure-of-the-4Fe-4S-cluster-binding-domain-and-active-site-in-AtThiC-a.png)
![[4Fe-4S] cluster oxidation and disassembly on exposure of FNR to oxygen ...](https://www.researchgate.net/profile/Elizabeth-Theil/publication/23485547/figure/fig4/AS:667806404194316@1536228862613/4Fe-4S-cluster-oxidation-and-disassembly-on-exposure-of-FNR-to-oxygen-see-text-for_Q320.jpg)

![Structures of [4Fe-4S] P of some [NiFe]-hydrogenases. (A, B, and C ...](https://mavink.com/images/loadingwhitetransparent.gif)
![The [4Fe-4S] cluster coordinated by cysteine residues in the structure ...](https://www.researchgate.net/profile/Mikhail-Nesterchuk/publication/225079775/figure/fig9/AS:202922995523593@1425392020538/The-4Fe-4S-cluster-coordinated-by-cysteine-residues-in-the-structure-of-RimO-56.png)
![Structures of some Fe-S clusters: [2Fe-2S], [4Fe-4S] and [3Fe-4S], with ...](https://www.researchgate.net/profile/Richard_Cammack2/publication/257709939/figure/fig1/AS:669533077532690@1536640533550/Structures-of-some-Fe-S-clusters-2Fe-2S-4Fe-4S-and-3Fe-4S-with-cysteine.png)
![Quick and Spontaneous Transformation between [3Fe–4S] and [4Fe–4S] Iron ...](https://www.mdpi.com/ijms/ijms-24-00833/article_deploy/html/images/ijms-24-00833-g003.png)

![Preparation and relevance of a series of [4Fe-3S] clusters with ...](https://www.researchgate.net/publication/336534705/figure/fig1/AS:814132840382464@1571115803120/Preparation-and-relevance-of-a-series-of-4Fe-3S-clusters-with-trigonal-planar-iron-a-A.png)

![Structures of [4Fe-4S] P of some [NiFe]-hydrogenases. (A, B, and C ...](https://www.researchgate.net/publication/328337001/figure/fig2/AS:743702297325569@1554323853219/Structures-of-4Fe-4S-P-of-some-NiFe-hydrogenases-A-B-and-C-S77HYB-in-the-HRED_Q320.jpg)


![4Fe-4S] cluster enzymes involved in DNA metabolism. | Download ...](https://www.researchgate.net/publication/369084550/figure/tbl1/AS:11431281125373277@1678286511809/4Fe-4S-cluster-enzymes-involved-in-DNA-metabolism_Q320.jpg)
![4Fe-4S] cluster enzymes involved in DNA metabolism. | Download ...](https://www.researchgate.net/publication/369084550/figure/fig1/AS:11431281125364885@1678286511506/figure-fig1_Q320.jpg)
![The [4Fe‐4S]‐Cluster of HydF is not Required for the Binding and ...](https://chemistry-europe.onlinelibrary.wiley.com/cms/asset/1b1bdaef-a950-41df-8bc0-e9eab1d6be17/cbic202300222-fig-0001-m.jpg)
![The reaction of [4Fe-4S] cluster with oxygen which acts as oxygen ...](https://www.researchgate.net/publication/295254502/figure/fig5/AS:668374619144198@1536364335371/Fig-6-The-reaction-of-4Fe-4S-cluster-with-oxygen-which-acts-as-oxygen-sensor-in.png)
![Proposed interaction of [4Fe-4S] cluster with nucleophiles through the ...](https://www.researchgate.net/profile/Qi-Zhang-176/publication/50939852/figure/fig4/AS:305852855668738@1449932411439/Proposed-interaction-of-4Fe-4S-cluster-with-nucleophiles-through-the-Fe-u-site-X.png)
![A designed heme-[4Fe-4S] metalloenzyme catalyzes sulfite reduction like ...](https://www.science.org/cms/10.1126/science.aat8474/asset/18f951e7-4bb3-44e7-b1e2-97a06ff33534/assets/graphic/361_1098_f3.jpeg)
![[4Fe-3S] reactivity with hydrazine and characterization of Fe–NH2 ...](https://www.researchgate.net/publication/336534705/figure/fig5/AS:814132840378375@1571115803360/4Fe-3S-reactivity-with-hydrazine-and-characterization-of-Fe-NH2-product-a-The-reaction.png)
![(A) Molecular structures of [4Fe-4S] and [8Fe-7S] P-cluster. (B ...](https://www.researchgate.net/publication/362090581/figure/fig1/AS:1179431255187468@1658209732088/A-Molecular-structures-of-4Fe-4S-and-8Fe-7S-P-cluster-B-Topology-of-4-site-and_Q320.jpg)
![Protonation/reduction dynamics at the [4Fe–4S] cluster of the hydrogen ...](https://pubs.rsc.org/image/article/2018/cp/c7cp04757f/c7cp04757f-f1_hi-res.gif)
![Effect of oxygen on stability of the [4Fe-4S] clusters in purified ...](https://www.researchgate.net/publication/223137066/figure/fig5/AS:484708548124673@1492574931383/Effect-of-oxygen-on-stability-of-the-4Fe-4S-clusters-in-purified-D-LHis-FeS.png)

![The [4Fe-4S] electron transfer sites of APS reductase. ( A ) Structural ...](https://www.researchgate.net/profile/Peter-Kroneck/publication/11519270/figure/fig2/AS:282347657285633@1444328335871/The-4Fe-4S-electron-transfer-sites-of-APS-reductase-A-Structural-alignment-of-the.png)

![Models for the biogenesis of [2Fe-2S] and [4Fee4S] proteins by the (A ...](https://www.researchgate.net/publication/345671880/figure/fig2/AS:971152671387661@1608552248957/Models-for-the-biogenesis-of-2Fe-2S-and-4Fee4S-proteins-by-the-A-bacterial-or-B.png)
x Intermediates of ...](https://chemistry-europe.onlinelibrary.wiley.com/cms/asset/7b59f47f-fa22-4a5a-8249-e70373cce844/chem201806113-toc-0001-m.jpg)
![X-ray crystal structure of [4Fe-4S] cluster regions in C42D FdI. The ...](https://www.researchgate.net/profile/Christopher_Bonagura/publication/12360023/figure/fig4/AS:601683189043216@1520463859768/X-ray-crystal-structure-of-4Fe-4S-cluster-regions-in-C42D-FdI-The-view-is-similar-to.png)


![Left-hand panel, from top EPR spectra of the [4Fe–4S] ferredoxin from ...](https://www.researchgate.net/profile/Richard-Cammack/publication/226791086/figure/fig1/AS:393664720326660@1470868391748/Left-hand-panel-from-top-EPR-spectra-of-the-4Fe-4S-ferredoxin-from-Desulfovibrio-gigas.png)
![The [4Fe-4S] cluster coordinated by cysteine residues in the structure ...](https://www.researchgate.net/profile/Mikhail-Nesterchuk/publication/225079775/figure/fig2/AS:202922995523586@1425392020363/Superposition-of-four-different-conformations-of-PrmA-Apo-enzyme-structures-are-colored_Q640.jpg)
![(PDF) Quick and Spontaneous Transformation between [3Fe–4S] and [4Fe–4S ...](https://www.researchgate.net/publication/366854644/figure/fig4/AS:11431281111422646@1672955167948/Schematic-diagram-of-the-proposed-changes-of-the-Fe-S-cluster-bound-to-TtuA-One_Q320.jpg)
![Temperature-induced unfolding comparison of the [4Fe-4S] 2+ and ...](https://www.researchgate.net/profile/Santiago-Mansilla/publication/368223041/figure/fig1/AS:11431281133222650@1680272572023/Temperature-induced-unfolding-comparison-of-the-4Fe-4S-2-and-3Fe-4S-states-of.png)

![Proposed model for the assembly of a [4Fe-4S] cluster on NFU1. (A) Two ...](https://www.researchgate.net/profile/Anshika-Jain-3/publication/343584607/figure/fig10/AS:987165911691277@1612370102745/Proposed-model-for-the-assembly-of-a-4Fe-4S-cluster-on-NFU1-A-Two-2Fe-2S-clusters.png)


![Insight into the Redox Behavior of the [4Fe–4S] Subcluster in [FeFe ...](https://pubs.acs.org/cms/10.1021/acscatal.0c02771/asset/images/large/cs0c02771_0005.jpeg)
![Reversible cycling between cysteine persulfide-ligated [2Fe-2S] and ...](https://www.pnas.org/cms/10.1073/pnas.1208787109/asset/b2e905e2-4b7e-4f98-b0f9-88d02533c683/assets/graphic/pnas.1208787109fig01.jpeg)
![4Fe-4S] cluster enzymes involved in DNA metabolism. | Download ...](https://www.researchgate.net/publication/369084550/figure/tbl1/AS:11431281125373277@1678286511809/4Fe-4S-cluster-enzymes-involved-in-DNA-metabolism.png)
![Mitochondrial [4Fe-4S] protein assembly involves reductive [2Fe-2S ...](https://www.pnas.org/cms/10.1073/pnas.2003982117/asset/5c191462-1cfe-4fb8-82bf-0cf8ce85e0dd/assets/images/large/pnas.2003982117fig03.jpg)

![Copper largely blocks the [4Fe-4S] cluster assembly in the E. coli ...](https://www.researchgate.net/profile/Yilin-Pang-3/publication/263295853/figure/fig6/AS:272698450378786@1442027785343/Copper-largely-blocks-the-4Fe-4S-cluster-assembly-in-the-E-coli-cellsA-Inhibition-of.png)

![[4Fe-3S] reactivity with hydrazine and characterization of Fe–NH2 ...](https://www.researchgate.net/publication/336534705/figure/fig2/AS:814132840394753@1571115803172/Structural-analogy-between-4Fe-3S-and-the-FeMoco-a-b-The-Fe-S-bond-distances-at-the_Q320.jpg)
![Model of the impact of the [4Fe-4S] clusters in the FLD of Rpo3 on the ...](https://www.researchgate.net/publication/306943512/figure/fig2/AS:399354406948881@1472224918838/Model-of-the-impact-of-the-4Fe-4S-clusters-in-the-FLD-of-Rpo3-on-the-formation-of-RNAP.png)
![Cytosolic [4Fe-4S] iron-sulfur cluster assembly and targeting ...](https://www.researchgate.net/publication/355835068/figure/fig2/AS:1085505341009922@1635816049288/Wide-range-of-use-of-Fe-S-clusters-A-Mitochondrial-respiratory-chain-NADH_Q640.jpg)


![Cytosolic [4Fe-4S] iron-sulfur cluster assembly and targeting ...](https://www.researchgate.net/publication/355835068/figure/fig3/AS:1085505341001728@1635816049332/Late-stage-of-mitochondrial-Fe-S-cluster-synthesis-GLRX5-monothiol-glutaredoxin-5-GSH_Q640.jpg)
![The [4Fe-4S] cluster of SePhrB. (A) The binding site of the [4Fe-4S ...](https://www.researchgate.net/publication/372301754/figure/fig2/AS:11431281174263009@1689170590742/The-4Fe-4S-cluster-of-SePhrB-A-The-binding-site-of-the-4Fe-4S-cluster-and-vicinal.png)
![A) Lewis structure of the unusual [4Fe-3S] (proximal) cluster of ...](https://www.researchgate.net/profile/Giorgio-Caserta/publication/356147211/figure/fig3/AS:1089672965029888@1636809688110/A-Lewis-structure-of-the-unusual-4Fe-3S-proximal-cluster-of-membrane-bound.png)
![X-ray crystal structure of [4Fe-4S] cluster regions in C42D FdI. The ...](https://www.researchgate.net/profile/Christopher-Bonagura/publication/12360023/figure/fig1/AS:601683189059601@1520463859677/Structures-of-3Fe-4S-and-4Fe-4S-clusters-S-inorganic-sulfide-S-cys-cysteine_Q320.jpg)
![Structures of some Fe-S clusters: [2Fe-2S], [4Fe-4S] and [3Fe-4S], with ...](https://www.researchgate.net/profile/Richard_Cammack2/publication/257709939/figure/fig1/AS:669533077532690@1536640533550/Structures-of-some-Fe-S-clusters-2Fe-2S-4Fe-4S-and-3Fe-4S-with-cysteine_Q320.jpg)
![Planar three-coordinate iron sulfide in a synthetic [4Fe-3S] cluster ...](https://media.springernature.com/lw685/springer-static/image/art:10.1038/s41557-019-0341-7/MediaObjects/41557_2019_341_Fig2_HTML.png)
![The FeoC [4Fe-4S] Cluster Is Redox-Active and Rapidly Oxygen-Sensitive ...](https://xpic.x-mol.com/20191123/10.1021_acs.biochem.9b00745.jpg)
![A model for the [4Fe-4S] cluster in the PduT pore. A, shown is the PduT ...](https://www.researchgate.net/profile/Duilio-Cascio/publication/46427219/figure/fig6/AS:350116289499138@1460485636118/A-model-for-the-4Fe-4S-cluster-in-the-PduT-pore-A-shown-is-the-PduT-trimer-pore-and.png)

![Structures of some Fe-S clusters: [2Fe-2S], [4Fe-4S] and [3Fe-4S], with ...](https://www.researchgate.net/profile/Richard-Cammack/publication/257709939/figure/fig2/AS:669533077520409@1536640533625/Electron-transfer-chains-of-Fe-S-clusters-in-a-membrane-extrinsic-domain-of-Complex-I_Q320.jpg)
![Proposed interaction of [4Fe-4S] cluster with nucleophiles through the ...](https://www.researchgate.net/profile/Qi-Zhang-176/publication/232317111/figure/fig4/AS:300599204696068@1448679843860/Proposed-interaction-of-4Fe-4S-cluster-with-nucleophiles-through-the-Fe-u-site-X_Q320.jpg)


![A close-up view of the [4Fe– 4S] cluster region of the human MUTYH. The ...](https://www.researchgate.net/profile/Paolo-Degan/publication/260380759/figure/fig6/AS:297096172326928@1447844655936/A-close-up-view-of-the-4Fe-4S-cluster-region-of-the-human-MUTYH-The-4Fe-4S-cluster.png)


![Mitochondrial [4Fe-4S] protein assembly involves reductive [2Fe-2S ...](https://www.pnas.org/cms/10.1073/pnas.2003982117/asset/dd20de68-4faa-4e49-b6e7-767b91b2fa43/assets/images/large/pnas.2003982117fig06.jpg)
![[4Fe−4S] 2+ ISCA1−NFU1 transfers the cluster to the FeS RS site of AI ...](https://www.researchgate.net/publication/359541154/figure/fig4/AS:1143364384755720@1649610720946/4Fe-4S-2-ISCA1-NFU1-transfers-the-cluster-to-the-FeS-RS-site-of-AI-LIAS-A-and-B_Q320.jpg)
![N‐Coordinated [2Fe–2S] and [4Fe–4S] Clusters: Synthesis, Structures and ...](https://chemistry-europe.onlinelibrary.wiley.com/cms/asset/4640d62d-41ca-4025-9897-22e93b76d8ae/mfig000.jpg)


![Redox-dependent conformational changes of a proximal [4Fe–4S] cluster ...](https://pubs.rsc.org/image/article/2018/cc/c8cc06261g/c8cc06261g-f1_hi-res.gif)
![Mitochondrial [4Fe-4S] protein assembly involves reductive [2Fe-2S ...](https://www.pnas.org/cms/10.1073/pnas.2003982117/asset/8c4fea1f-08a9-43d7-93ed-aa04e953f16d/assets/images/large/pnas.2003982117fig01.jpg)
![Maturation of the [Ni–4Fe–4S] active site of carbon monoxide ...](https://media.springernature.com/lw685/springer-static/image/art:10.1007/s00775-018-1541-0/MediaObjects/775_2018_1541_Fig1_HTML.png)

![Superposition of the [4Fe-4S] cluster binding regions in three ...](https://www.researchgate.net/profile/Christopher-Bonagura/publication/232284064/figure/fig5/AS:669041798696986@1536523403784/Details-of-the-L44S-AvFdI-mutant-structures-and-comparison-to-native-AvFdI-and-PaFd-A_Q640.jpg)

![The auxiliary [4Fe–4S] cluster of the Radical SAM heme synthase from ...](https://pubs.rsc.org/image/article/2016/sc/c6sc01140c/c6sc01140c-f1_hi-res.gif)
![仿生 [4Fe-4S] 化合物的分子氧反应性表现出 [4Fe-4S] 到 [2Fe-2S] 簇的转换,Journal of Inorganic ...](https://xpic.x-mol.com/20220113/10.1016_j.jinorgbio.2022.111714.jpg)
![Protonation/reduction dynamics at the [4Fe–4S] cluster of the hydrogen ...](https://pubs.rsc.org/image/article/2018/cp/c7cp04757f/c7cp04757f-f8_hi-res.gif)
![Cytosolic [4Fe-4S] iron-sulfur cluster assembly and targeting ...](https://www.researchgate.net/publication/355835068/figure/fig4/AS:1085505340997633@1635816049370/Cytosolic-4Fe-4S-iron-sulfur-cluster-assembly-and-targeting-machinery-ABCb7.jpg)