2fe Algorithm
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![Possible sequence of events leading to the [2Fe]H cluster assembly. In ...](https://www.researchgate.net/publication/328239931/figure/fig3/AS:680932537294852@1539358376286/Possible-sequence-of-events-leading-to-the-2FeH-cluster-assembly-In-this-hypothesis.png)

![Mechanistic working model for the reaction cycle of [2Fe-2S] cluster ...](https://www.researchgate.net/publication/356549595/figure/fig7/AS:1094263630770176@1637904188211/Mechanistic-working-model-for-the-reaction-cycle-of-2Fe-2S-cluster-formation-on-an.png)

![Electron-density omit 2f o – f c maps of the [2Fe–2S] cluster in the ...](https://www.researchgate.net/profile/Ulf-Ryde/publication/26825897/figure/fig2/AS:340589422891009@1458214254306/Electron-density-omit-2f-o-f-c-maps-of-the-2Fe-2S-cluster-in-the-original-crystal.png)
![(a) COM distance evolutions between the [2Fe−2S] cluster and the ...](https://www.researchgate.net/profile/Binju-Wang/publication/348470933/figure/fig5/AS:991820704129026@1613479891186/a-COM-distance-evolutions-between-the-2Fe-2S-cluster-and-the-heme-Fe-during-the-MD.png)

![a, b Schemes showing two possible binding modes of the [2Fe-2S] centre ...](https://www.researchgate.net/profile/Isabel-Abreu/publication/8211620/figure/download/fig7/AS:667630801268739@1536186995283/a-b-Schemes-showing-two-possible-binding-modes-of-the-2Fe-2S-centre-in-the-putative.png)
![Requirements for the biogenesis of [2Fe-2S] proteins in the human and ...](https://www.pnas.org/cms/10.1073/pnas.2400740121/asset/9cfe6e2e-d732-44b8-a859-f21b9f9a53af/assets/images/large/pnas.2400740121fig02.jpg)

![Facile transfer of [2Fe-2S] clusters from the diabetes drug target ...](https://www.pnas.org/cms/10.1073/pnas.1109986108/asset/a7856518-6a10-4119-be44-5958045bcd7e/assets/graphic/pnas.1109986108fig3.jpeg)
![Reduction potentials of the [2Fe–2S] clusters in the overproduced 24 ...](https://www.researchgate.net/publication/256191354/figure/fig3/AS:392615024447503@1470618124446/Reduction-potentials-of-the-2Fe-2S-clusters-in-the-overproduced-24-kDa-subunit-variants.png)

![The Redox Active [2Fe-2S] Clusters: Key-Components of a Plethora of ...](https://www.mdpi.com/inorganics/inorganics-10-00014/article_deploy/html/images/inorganics-10-00014-g009.png)
![Scheme 1. Two mechanisms proposed for [2Fe-2S] cluster assembly within ...](https://www.researchgate.net/profile/Sandrine-Choudens/publication/6456992/figure/fig1/AS:738119783575556@1552992878579/Scheme-1-Two-mechanisms-proposed-for-2Fe-2S-cluster-assembly-within-a-scaffold.png)

![Biosynthesis of the [2Fe] H subcluster. A. HydG catalyses two reactions ...](https://www.researchgate.net/publication/359482808/figure/fig1/AS:1183086930870272@1659081313551/Active-site-H-cluster-of-FeFe-hydrogenases-The-H-cluster-constitutes-two-subclusters_Q320.jpg)

![The environment of the [2Fe–2S] cluster in the 24 kDa subunit of ...](https://www.researchgate.net/profile/Thorsten-Friedrich/publication/256191354/figure/fig2/AS:392615024447502@1470618124423/The-environment-of-the-2Fe-2S-cluster-in-the-24-kDa-subunit-of-complex-I-A-The-region.png)
![The 2Fe-2S cluster of succinate dehydrogenase [9]. | Download ...](https://www.researchgate.net/profile/Dorota_Kregiel/publication/260943922/figure/download/fig3/AS:392515342618629@1470594358625/The-2Fe-2S-cluster-of-succinate-dehydrogenase-9.png)

![Binding of the [2Fe-2S] cluster in the C-terminal domain of mitoNEET ...](https://www.researchgate.net/publication/363374447/figure/fig1/AS:11431281083538412@1662650871482/Binding-of-the-2Fe-2S-cluster-in-the-C-terminal-domain-of-mitoNEET-mitoNEET-45-108_Q320.jpg)
![Schematic views of the different positions of the [2Fe-2S] cluster ...](https://www.researchgate.net/profile/Fevzi-Daldal-2/publication/11648425/figure/fig5/AS:487261201539072@1493183531019/Schematic-views-of-the-different-positions-of-the-2Fe-2S-cluster-domain-in-a-wild-type.png)

![The most common structures and oxidation levels of [2Fe–2S], [3Fe–4S ...](https://www.researchgate.net/publication/275208371/figure/fig7/AS:267891450839069@1440881707488/The-most-common-structures-and-oxidation-levels-of-2Fe-2S-3Fe-4S-and-4Fe-4S.png)
![Requirements for the biogenesis of [2Fe-2S] proteins in the human and ...](https://www.pnas.org/cms/10.1073/pnas.2400740121/asset/2be4d4dc-9010-4549-b357-3dd9ecf6ff3e/assets/images/large/pnas.2400740121fig08.jpg)

![Interconversion between [2Fe–2S] and [4Fe–4S] cluster glutathione ...](https://pubs.rsc.org/image/article/2022/cc/d1cc03566e/d1cc03566e-t2_hi-res.gif)
![[2Fe−2S] 2 -GLRX3 2 -GS 4 transfers [2Fe−2S] 2+ clusters to wtNUBP1 ...](https://mavink.com/images/loadingwhitetransparent.gif)


![The effect of loss of the [2Fe-2S] cluster on complex formation and ...](https://www.researchgate.net/profile/Jason-Crack/publication/6074678/figure/fig5/AS:667608739246091@1536181735324/The-effect-of-loss-of-the-2Fe-2S-cluster-on-complex-formation-and-folding-A.png)
![Structure of a [2Fe-2S] cluster ( Upper ) and [4Fe-4S] cluster ( Lower ...](https://www.researchgate.net/profile/Jeverson-Frazzon/publication/11605741/figure/download/fig1/AS:281869057839110@1444214228167/Structure-of-a-2Fe-2S-cluster-Upper-and-4Fe-4S-cluster-Lower-Cysteinyl.png)
![Transfer of [2Fe-2S]/Fe from mNT's mutants to permeabilized HEK293 ...](https://www.researchgate.net/profile/John-Zuris/publication/51520539/figure/fig1/AS:305774975832068@1449913843800/Facile-transfer-of-the-2Fe-2S-cluster-from-mitoNEET-mNT-to-apo-ferredoxin-a-Fd-The_Q320.jpg)


![[2Fe–2S] Cluster Supported by Redox-Active o-Phenylenediamide Ligands ...](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bbb/8453056/a1082dc9fe4e/nihms-1713270-f0013.jpg)
![A [2Fe-1S] Complex That Affords Access to Bimetallic and Higher ...](https://xpic.x-mol.com/20190619/10.1021_acs.inorgchem.9b01212.jpg)
![Biomimetic [2Fe‐2S] Clusters with Extensively Delocalized Mixed‐Valence ...](https://onlinelibrary.wiley.com/cms/asset/c634a20e-df02-40f3-bf68-9e5cdc10995a/mcontent.jpg)
![a For the [2Fe-2S] in the 14\documentclass[12pt]{minimal}... | Download ...](https://www.researchgate.net/profile/Amgalanbaatar-Baldansuren/publication/312020136/figure/fig2/AS:960325801238550@1605970921228/a-For-the-2Fe-2S-in-the-14documentclass12ptminimal-usepackageamsmath.gif)

![The [2Fe-2S]-GLRX52 homo-dimeric complex is converted into the H96R ...](https://www.researchgate.net/publication/372745659/figure/fig3/AS:11431281183066004@1692699391893/The-2Fe-2S-GLRX52-homo-dimeric-complex-is-converted-into-the-H96R-BOLA3-2Fe-2S-GLRX5_Q320.jpg)
![Nomenclature for the [2Fe]H active site of the [FeFe]-hydrogenases ...](https://www.researchgate.net/publication/356274464/figure/fig1/AS:11431281183002590@1692659390660/Nomenclature-for-the-2FeH-active-site-of-the-FeFe-hydrogenases_Q320.jpg)
![Electron-density omit 2f o – f c maps of the [2Fe–2S] cluster in the ...](https://www.researchgate.net/profile/Ulf-Ryde/publication/26825897/figure/fig2/AS:340589422891009@1458214254306/Electron-density-omit-2f-o-f-c-maps-of-the-2Fe-2S-cluster-in-the-original-crystal_Q320.jpg)
![Comparison of the relative position of the [2Fe-2S] cluster and FAD in ...](https://www.researchgate.net/profile/Yoko-Kimata-Ariga/publication/312483505/figure/fig2/AS:962151481098246@1606406197227/Comparison-of-the-relative-position-of-the-2Fe-2S-cluster-and-FAD-in-root-and-leaf.gif)
![Oxidized and reduced [2Fe–2S] clusters from an iron(I) synthon ...](https://media.springernature.com/lw785/springer-static/image/art:10.1007%2Fs00775-015-1272-4/MediaObjects/775_2015_1272_Fig1_HTML.gif)
![Characterization of [2Fe-2S]-Cluster-Bridged Protein Complexes and ...](https://xpic.x-mol.com/20200304/10.1002_anie.201915615.jpg)
![[2Fe–2S] Cluster Supported by Redox-Active o-Phenylenediamide Ligands ...](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bbb/8453056/55bfd9287639/nihms-1713270-f0001.jpg)
![Table 1 from A [2Fe-1S] Complex That Affords Access to Bimetallic and ...](https://ai2-s2-public.s3.amazonaws.com/figures/2017-08-08/0cd647e3a086487488ea19b5de2106db59a12a49/17-Table1-1.png)

![A Super-Reduced Diferrous [2Fe–2S] Cluster | Journal of the American ...](https://pubs.acs.org/cms/10.1021/ja311563y/asset/images/medium/ja-2012-11563y_0006.gif)
![Bond-length distances in the [2Fe±2S] cluster | Download Table](https://www.researchgate.net/profile/Alessandro-Aliverti/publication/13200622/figure/tbl2/AS:667213107310605@1536087409600/Bond-length-distances-in-the-2Fe2S-cluster_Q320.jpg)
![Spontaneous activation of [FeFe]-hydrogenases by an inorganic [2Fe ...](https://europepmc.org/articles/PMC3795299/bin/emss-54738-f0001.jpg)


![The Redox Active [2Fe-2S] Clusters: Key-Components of a Plethora of ...](https://pub.mdpi-res.com/inorganics/inorganics-10-00014/article_deploy/html/images/inorganics-10-00014-g007.png?1642486267)
![Figure S2. The multiple sequence analysis of [2Fe-2S] NpFdxs (a) and ...](https://www.researchgate.net/profile/Jerome-Wenger/publication/335153081/figure/fig7/AS:976258108256257@1609769479083/Figure-S2-The-multiple-sequence-analysis-of-2Fe-2S-NpFdxs-a-and-4Fe-4S-NpFdxs-b.jpg)
![Interaction between the [2Fe] subcluster of [FeFe]-hydrogenases and ...](https://www.researchgate.net/publication/51823683/figure/fig1/AS:487471290032128@1493233620686/Interaction-between-the-2Fe-subcluster-of-FeFe-hydrogenases-and-surrounding-amino.png)

![Mechanistic working model for the reaction cycle of [2Fe-2S] cluster ...](https://www.researchgate.net/publication/356549595/figure/fig5/AS:1094263626567682@1637904187265/The-N-terminal-Tyr35-of-ISCU2-is-not-required-for-persulfide-reduction-yet-essential-for_Q640.jpg)


![Frontiers | Nitric oxide reversibly binds the reduced [2Fe-2S] cluster ...](https://www.frontiersin.org/files/Articles/995421/fmolb-09-995421-HTML-r2/image_m/fmolb-09-995421-g002.jpg)
![Requirements for the biogenesis of [2Fe-2S] proteins in the human and ...](https://www.pnas.org/cms/10.1073/pnas.2400740121/asset/b4e40aaf-d18d-4c9c-ac96-ec6269beb69d/assets/images/large/pnas.2400740121fig07.jpg)
![Facile transfer of [2Fe-2S] clusters from the diabetes drug target ...](https://www.pnas.org/cms/10.1073/pnas.1109986108/asset/152262d4-ad6d-47cb-9e48-f38942cb2ec2/assets/graphic/pnas.1109986108fig6.jpeg)
![Mitochondrial [2Fe‐2S] ferredoxins: new functions for old dogs - Schulz ...](https://febs.onlinelibrary.wiley.com/cms/asset/0eefb9d8-f886-4ea2-bb1a-f9a9feb8a59d/feb214546-fig-0001-m.png)
![The most common structures and oxidation levels of [2Fe–2S], [3Fe–4S ...](https://www.researchgate.net/profile/Prabhuodeyara-M-Gurubasavaraj/publication/275208371/figure/tbl1/AS:667088733630478@1536057756739/CV-data-for-2Fe-2S-complexes-E-1-2-V-a-b-Reference-Fe-3-Fe-3-Fe-3-Fe-2-Fe-3-Fe_Q640.jpg)
![来自[2Fe-2S]簇的催化金属聚合物:用于产氢的人造金属酶。,Angewandte Chemie International Edition ...](https://xpic.x-mol.com/paperImg/2020_03_12/Angewandte_Chemie_International_Edition_All_img/10.1002_anie.201813776.jpg)
![Schematic hydrogen-bonding network of the [2Fe-2S] cluster and the ...](https://www.researchgate.net/profile/Antony-Crofts/publication/40730800/figure/fig1/AS:308045159649280@1450455097677/Schematic-hydrogen-bonding-network-of-the-2Fe-2S-cluster-and-the-surrounding-amino.png)

![High symmetry structures of the 4-Cys-[2Fe-2S] complex, specifically ...](https://www.researchgate.net/publication/308504275/figure/fig14/AS:410781851111424@1474949433333/High-symmetry-structures-of-the-4-Cys-2Fe-2S-complex-specifically.png)
![The active site of (a) Fe-only Hydrogenase, the [2Fe]H subcluster, (b ...](https://www.researchgate.net/publication/249916700/figure/fig1/AS:11431281128223173@1679318539060/The-active-site-of-a-Fe-only-Hydrogenase-the-2FeH-subcluster-b-its-synthetic_Q320.jpg)
![Figure 5 from The [2Fe-2S] Cluster E m as an Indicator of the Iron ...](https://ai2-s2-public.s3.amazonaws.com/figures/2017-08-08/b9601ce5fe9aed7f9b50c4eec14f58506835da49/5-Figure5-1.png)

![a Stereoview of the electron density and model for the [2Fe–2S] cluster ...](https://www.researchgate.net/profile/Luet-Wong/publication/38081117/figure/fig3/AS:492193451384834@1494359471687/a-Stereoview-of-the-electron-density-and-model-for-the-2Fe-2S-cluster-in-the-A105R_Q640.jpg)
![N‐Coordinated [2Fe–2S] and [4Fe–4S] Clusters: Synthesis, Structures and ...](https://chemistry-europe.onlinelibrary.wiley.com/cms/asset/4c7a7c28-c4f8-44ae-909d-d08d7a7ad13c/mfig000.jpg)

![Binding of the [2Fe-2S] cluster in the C-terminal domain of mitoNEET ...](https://www.researchgate.net/publication/363374447/figure/fig1/AS:11431281083538412@1662650871482/Binding-of-the-2Fe-2S-cluster-in-the-C-terminal-domain-of-mitoNEET-mitoNEET-45-108.png)
![Binding of a [2Fe–2S] cluster in the Fur proteins expressed in the E ...](https://www.researchgate.net/publication/359597606/figure/fig1/AS:1164519137120256@1654654406038/Binding-of-a-2Fe-2S-cluster-in-the-Fur-proteins-expressed-in-the-E-coliiscA-sufA_Q320.jpg)
![Cyclic voltammetry of [2Fe-2S] peptides. Cyclic voltammetry of [2Fe-2S ...](https://www.researchgate.net/publication/361191387/figure/fig4/AS:11431281081307100@1661703320047/Cyclic-voltammetry-of-2Fe-2S-peptides-Cyclic-voltammetry-of-2Fe-2S-GCTVCG-A-and.png)
![Interaction between the [2Fe] subcluster of [FeFe]-hydrogenases and ...](https://www.researchgate.net/publication/51823683/figure/fig1/AS:487471290032128@1493233620686/Interaction-between-the-2Fe-subcluster-of-FeFe-hydrogenases-and-surrounding-amino_Q320.jpg)

![Characterization of binding and stability of the [2Fe-2S] cluster in ...](https://www.researchgate.net/profile/Ingrid-Span/publication/349071382/figure/fig3/AS:989767936266241@1612990473303/Characterization-of-binding-and-stability-of-the-2Fe-2S-cluster-in-the-Asp1-365-920.png)
![Reduction potentials of the [2Fe–2S] clusters in the overproduced 24 ...](https://www.researchgate.net/profile/Thorsten-Friedrich/publication/256191354/figure/fig3/AS:392615024447503@1470618124446/Reduction-potentials-of-the-2Fe-2S-clusters-in-the-overproduced-24-kDa-subunit-variants_Q640.jpg)





![Some systems having [2Fe-2S] core. | Download Scientific Diagram](https://www.researchgate.net/profile/Lemi-Turker/publication/225060898/figure/fig1/AS:213936747094016@1428017903786/Some-systems-having-2Fe-2S-core_Q640.jpg)

![Mutations to the Rieske [2Fe-2S] binding site in NdmD result in various ...](https://www.researchgate.net/profile/Meredith-Mock-2/publication/357166082/figure/fig5/AS:1102707645521922@1639917398704/Mutations-to-the-Rieske-2Fe-2S-binding-site-in-NdmD-result-in-various-levels-of-N-321_Q320.jpg)
![Frontiers | Nitric oxide reversibly binds the reduced [2Fe-2S] cluster ...](https://www.frontiersin.org/files/Articles/995421/fmolb-09-995421-HTML-r2/image_m/fmolb-09-995421-g005.jpg)


![Interconversion between [2Fe–2S] and [4Fe–4S] cluster glutathione ...](https://pubs.rsc.org/image/article/2022/cc/d1cc03566e/d1cc03566e-t1_hi-res.gif)
![Facile transfer of [2Fe-2S] clusters from the diabetes drug target ...](https://www.pnas.org/cms/10.1073/pnas.1109986108/asset/3f15aaed-3868-4401-921f-400f0256612c/assets/graphic/pnas.1109986108fig4.jpeg)

![NO binding at the reduced [2Fe-2S] cluster in mitoNEET 45-108 expressed ...](https://www.researchgate.net/publication/363374447/figure/fig4/AS:11431281083555873@1662650871660/NO-binding-at-the-reduced-2Fe-2S-cluster-in-mitoNEET-45-108-inhibits-the-redox_Q320.jpg)

![Structure of the [2Fe-2S] binding module in crosseye stereoview. ( A ...](https://www.researchgate.net/profile/Jinzhong_Lin4/publication/6074871/figure/fig3/AS:280450263207936@1443875961035/Structure-of-the-2Fe-2S-binding-module-in-crosseye-stereoview-A-Stick-and-ball.png)
![Model representations of [2Fe] biohybrids where the diironhexacarbonyl ...](https://www.researchgate.net/profile/Giorgio-Caserta/publication/320999422/figure/fig80/AS:631622135193628@1527601860431/Model-representations-of-2Fe-biohybrids-where-the-diironhexacarbonyl-complex-is.png)
